Human immunity. Infectious diseases. T-cells. Mycobacterium tuberculosis. Helen Hay Whitney Foundation Fellow.
Joined February 2015
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Paul Ogongo retweeted
We’re honored to welcome Hon. @Monica_Garcia_G, Minister of Health of Spain as co-chair of the 8th @GlobForumTBVax, underscoring Spain's commitment to #EndTB through innovation, equity and multilateral scientific collaboration. #8GFTBV
🔗Meet our team: bit.ly/8GFTBVcmtees
ALT Graphic with patterned frame and the 8th Global Forum logo, with a quote from Mónica García Gómez, Minister of Health, Spain, reading “The Spanish Ministry of Health reaffirms its strong commitment to ending tuberculosis through innovation, equity, and multilateral scientific collaboration. Supporting the 8th Global Forum on TB Vaccines reflects Spain’s dedication to advancing vaccine research, strengthening global partnerships, and translating scientific progress into sustainable public health impact. Hosting this Forum provides a valuable opportunity to reinforce cooperation with diverse international partners and to contribute to shared global priorities toward TB elimination.”
Paul Ogongo retweeted
Don't forget to save the date to join us in Zaragoza in April 2027 at the 8th #GlobForumTBVax as we come together as a global community to reaffirm our commitment to TB vaccine success in all its forms!
🔗Subscribe at tbvaccinesforum.org/subscrib…
ALT A graphic with a blue-yellow-green frame with text reading “Save the Date” and www.tbvaccinesforum.org. In the center is the logo of the 8th Global Forum on TB Vaccines, 12-14 April 2027, Zaragoza, Spain, with the logos of the organizing partners and a multi-coloured graphic of landmarks of Zaragoza.
Paul Ogongo retweeted
Join the WGNV Early Career Researcher Network for an interactive online discussion on effective grantwriting.
📆 30 July 2026
🕧 9:00am EST | 3:00pm CET and SAST | 6:30pm IST
🔗 Learn more and register: tinyurl.com/5dpw2per
Come share your work at the 8th @GlobaForumTBVax!
Are you interested in TB vaccine R&D and implementation? You're invited to submit abstracts covering the breadth of the field
📅 Submit by 30 Sep 2026
Learn more at bit.ly/8GFTBVabst
@newtbvaccines @TBVI_EU @unizar @StopTB
Paul Ogongo retweeted
Kenya reaffirms commitment to ending TB, calls for fair vaccine access kbc.co.ke/kenya-reaffirms-co…
Paul Ogongo retweeted
So we blocked IFNγ in Mtb infected macaques and….the animals were fine. Turns out mice overestimate the importance of IFNγ in TB because IFNγ drives iNOS in mice but not macaques or humans. This means we don’t actually know how T cells suppress Mtb. rdcu.be/ff9GB
Join us to learn about the science of implementing vaccine clinical trials. Register on the link to be part of the conversation.
Join the WGNV Early Career Researcher Network for an interactive online discussion on the TB vaccine clinical pipeline and career opportunities in clinical research.
📆 7 May 2026
🕧 9:00am EST | 3:00pm CET and SAST | 6:30pm IST
🔗 Learn more and register: tinyurl.com/n2j38px6
Studying 2 distinct human cohorts with recent exposure to #TB,
doi.org/10.1172/jci.insight.…
Paul Ogongo @JaTcells & team @UCSF find different individual Mycobacterium #tuberculosis antigens induce distinct T cell responses, with important implications for TB #vaccine development.
It was a fantastic meeting in Cape Town to celebrate progress and navigate through the challenges we face Tuberculosis research.
What a great group! 👏 39 Keystone Symposia & @gatesfoundation scholarship awardees joined us in Cape Town for #KSTB26. With ~1.5M TB deaths annually, this next generation of researchers is driving innovation, collaboration, and progress. #tuberculosis #KeystoneSymposia
FINALLY OUT: We describe a set of Mtb antigens that preferentially induce Th17 cells against Mtb infection. Th17 cells are associated with contained Mtb infection in humans and animal models of TB, suggesting a protective role.
insight.jci.org/articles/vie…
IN PRESS: Using Metaclonotypist, we discover dominant immune response to TB driven by a public HLA-associated TCR metaclonotypes. This work opens avenues for biomarker and Mtb antigen discovery for TB vaccine.
nature.com/articles/s41467-0…
Massive effort from my PhD supervisor, Al Leslie, and team analysing Mtb infected human lung tissue.
In a new study by Mbano, Liu, Leslie @UKZN et al., single-cell & spatial transcriptomics of human #TB lung tissues from individuals in South Africa revealed that MMP1⁺CXCL5⁺ #fibroblasts & SPP1⁺ #macrophages are linked to TB disease & TB lung #granuloma hubs.la/Q03ZLxqt0
Paul Ogongo retweeted
We still don’t understand how T cells control tuberculosis. Our new paper shows that Mtb-specific T cells in NHP and human lung granulomas make many interesting effector molecules upon TCR stimulation. There’s a whole lot more to T cells in TB than IFNγ!
cell.com/iscience/fulltext/S…
Paul Ogongo retweeted
Join the #WGNV ECR Network - Virtual Coffee Corner on 4 December 2025 to network, share experiences, and talk about #TBvaccine activities of interest.
📅Date: Thur 4 Dec 2025
🕑Time: 9:00 am EDT / 3:00pm CET | 4:00pm SAST | 7:30 pm IST
🔗tinyurl.com/kj7kuuft
Fresh out in preprint from @justinelevan and the Feeney lab @UCSF_EXPM
Congenital CMV infection drives oligoclonal expansion of cytotoxic γδ T cells from early fetal progenitors biorxiv.org/content/10.1101/… #biorxiv_immuno
Paul Ogongo retweeted
In the study, Owen Leddy and colleagues used human phagocytic cells to map TB peptides that activate CD4+ T cells, a key immune defense. Guided by this, they designed mRNA immunogens that dramatically improved antigen presentation, offering a promising path toward an effective TB vaccine.
👥 @TheBrysonLab, @JaTcells, @Qingyun_Liu, @HeyuanMNi, et al.
🏛️ @ragoninstitute, @MITdeptofBE, @kochinstitute, @UCSF_EXPM, @UNC_SOM, @AHRI_ETH
💰 @theNCI, @NIAIDNews, @NIH_NIEHS
📘 @ScienceTM: science.org/doi/10.1126/scit…
ALT Screenshot from the linked article in Science Translational Medicine, “Immunopeptidomics can inform the design of mRNA vaccines for the delivery of Mycobacterium tuberculosis MHC class II antigens.”
Paul Ogongo retweeted
Mycobacterium tuberculosis triggers reduced inflammatory cytokine responses and virulence in mice lacking Tax1bp1
journals.plos.org/plospathog…
Thanks @TheBrysonLab for the tweetorial as always and the cool science!
Many of the peptides we identified are immunogenic per IEDB. We teamed up with @JaTCells to examine T cell responses to novel epitopes in a small cohort of individuals with prior Mtb exposure and found that some of these novel epitopes identified by MS are also immunogenic.
NOW PUBLISHED: science.org/doi/10.1126/scit…
Join us at the ECR Coffee Corner at the @newtbvaccines on Nov 6 2025. Looking forward to reconnecting this Early Career Researchers in Tuberculosis.
Join the #WGNV ECR Network - Virtual Coffee Corner on 6 November 2025 to network, share experiences, and talk about #TBvaccine activities of interest.
📅Date: Thur 6 Nov 2025
🕑Time: 9:00 am EDT / 3:00pm CET | 4:00pm SAST | 7:30 pm IST
🔗Register at tinyurl.com/ra6jv6en
Congratulations to Prof Ndung'u @Thumbi_Ndungu. A role model and an inspiration to many.
Congratulations to #SANTHE Director @Thumbi_Ndungu who was inducted into the US National Academy of Medicine @theNAMedicine this Saturday for his contributions to medical science & global health.
#AfricanLedScience
@SciforAfrica @gatesfoundation @Aidsfonds @ragoninstitute @ucl
