@JPhilBecker

Biochemist working on therapeutic oligonucleotides. Currently doing a postdoctoral fellowship at UMass Medical School

 Massachusetts
Joined May 2020
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  • Followers100
8Media
Hot off the press: Excited to share a fantastic review from our very own @WellerCelly, just published in CHIMIA! "Oligonucleotide-based PROTACs to Degrade RNA- and DNA-Binding Proteins" Check out the full review here: doi.org/10.2533/chimia.2025.…
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This one goes out to all the oligo chemists - we made the chemdraw feature public and added a few new functions here and there. Check it out!
Oligowizard@Oligowizard17 Nov 2024
The chemical structure drawing tool is now publicly available - no sign-up required! Check it out at: oligowizard.com/structures/ #oligotherapeutics #RNA #oligos

Structures - Oligowizard

Generate Chemical Structures of oligonucleotides from their seqeucen

oligowizard.com
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At the 2024 OTS meeting in Montreal!
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Version 4.0 is live! Fresh design, more customisation, professional HPLC traces, batch processing and generating ChemDraw structures from sequences All now oligowizard.com !

Oligowizard

Nucleic Acid Calculator - Software Toolbox for Oligo Chemists. Calculate molecular weights for nucleic acids like DNA, RNA, and modified backbones including Phosphodiester (PO) and Phosphorothioate...

oligowizard.com
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Register Now & Submit Abstracts for the 2nd Swiss RNA Therapeutics Summit, January 25, 2024, @unibern. rnatx.ch @Roche @kanton_bern Economic Development Agency @C_Leumann @PNioi @MartinJinek @snsf_ch @ETH_en
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The Jonathan Hall lab @ETH_DCHAB @ETH_en had a fantastic time at the #oligomeeting #ots23 by the @OTSociety !! Four days of fantastic talks and stimulating exchanges! Huge congrats to Mathilde Vincent @mathilde9v and Štefan Moravčík for winning the poster prizes!
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Lots of phenomenal exchanges and ideas at #oligomeeting #ots23 hosted by @OTSociety ! Thanks to everyone for the great discussions; and thanks to the OTS for the travel grant!!
Phil Becker@JPhilBecker23 Oct 2023
Very excited to present our work on oligo-conjugates towards the treatment of EPP @OTSociety #ots #ots23 #oligomeeting #oligotherapeutics Here’s a teaser: 🧵
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LAA discussion went to controls ⁦@OTSociety⁩ #ots23 As ⁦@F_ANAtico⁩ mentioned there is a great review about this inspired by work from both winners Guidelines for Experiments Using Antisense Oligonucleotides and Double-Stranded RNAs - PubMed pubmed.ncbi.nlm.nih.gov/3090…

Guidelines for Experiments Using Antisense Oligonucleotides and Double-Stranded RNAs - PubMed

After decades of research and development, synthetic nucleic acids are beginning to enjoy significant success in the clinic. Approved drugs have increased interest in the field, and many basic...

pubmed.ncbi.nlm.nih.gov
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Very excited to present our work on oligo-conjugates towards the treatment of EPP @OTSociety #ots #ots23 #oligomeeting #oligotherapeutics Here’s a teaser: 🧵
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But can we reproduce this splicing correction in our new vivo model? Come and find out at P23 tonight! Big thanks to @NCCR_RNADisease and @snsf_ch for funding the project! I’m also very grateful to @SwissChemistry and @SCNATChemistry for the chemistry travel award!!
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Check out P149 by @EvaMariaManz2 to learn about base editing to treat the EPP SNP, P167 by Štefan Moravčík on selective/chemical RNA methylation, P235 by @mathilde9v on the influence of PS linkages on oligo-protein interactions, and P239 by @WellerCelly on RNA PROTACS!
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In new work resulting from a collab. with @Roche, we show peptide conjugates of an #ASO 🧬 are inactive in cells due to endosomal entrapment. Getting #oligos into cells is only half the battle - the next question is how do we get them out of endosomes? ⭐️ doi.org/10.1021/acsomega.3c0…

Peptide Conjugates of a 2′‑O‑Methoxyethyl Phosphorothioate Splice-Switching Oligonucleotide Show...

Abstract. Antisense oligonucleotides (ASOs) are short, single-stranded nucleic acid molecules that alter gene expression. However, their transport into app

pubs.acs.org
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Great talk at @ETH by @DrMikeBooth on #oligonucleotides and how they can be turned into light-sensitive switches!
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While teaching a new undergrad student today, I compared cell culture work to keeping a tamagotchi alive. They had never heard of tamagotchis before…
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Paper by the lab of J. Hall (@ETH_en ) in collaboration with the C. Catapano group (@USI_en) "Pharmacological #inhibition of Lin28 promotes #ketogenesis and restores #lipid #homeostasis in models of non-alcoholic #fatty #liver #disease" @NatureComms bit.ly/3ZgJpL6 #RNA
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Out online OA now: Zihan Zhu (@AmandaZihanZhu), Ervin Fodor (@fodorlab) and Jeremy R. Keown (@JeremyKeown1) review recent advances on the molecular mechanisms of #influenza virus genome replication cell.com/trends/microbiology…

A structural understanding of influenza virus genome replication

Influenza virus contains a single-stranded negative-sense RNA genome. Replication of the genome is carried out by the viral RNA-dependent RNA polymerase in the context of the viral ribonucleoprotein...

cell.com
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We have a PhD project on the molecular mechanisms of influenza virus replication. Please consider joining our team and department @Dunn_School. #LoveVirology #PhD #influenza findaphd.com/phds/project/mo…

Molecular mechanisms of RNA virus replication at University of Oxford on FindAPhD.com

PhD Project - Molecular mechanisms of RNA virus replication at University of Oxford, listed on FindAPhD.com

findaphd.com
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Super happy and grateful for all the great discussions and stimulating questions so far! If you want to learn about therapeutic oligos and their delivery come and see mine and @SebastianSjstr1 posters (T02 / T08) in the next session tonight @GBM_eV in #Mosbach!
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