@JPata_

🔬🦠 Membrane protein and structural biology research#tomographyteam. PhD at MMSB, Lyon 🇫🇷 Currently Post-doc at the Center for Soft Nanoscience, Münster 🇩🇪

 France
Joined March 2020
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biorxiv.org/content/10.1101/… Glad to finally share the preprint of my main PhD project on the structure and dynamics of Cdr1. Using CryoEM, we solved different structures, with antifungal drugs, showing the role of this protein in drug resistance phenotypes.

CryoEM of ATP-driven dynamics and itraconazole binding in a fungal ABC pump

Azole resistance in Candida species often results from overexpression of the ABC transporter Cdr1, which expels drugs via ATP-driven conformational changes. Despite its clinical relevance, the...

biorxiv.org
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Using 3DVA of @cryosparc, we were able to image the full conformational landscape after ATP hydrolysis, and propose a function for the ABC signature motif. A big thanks to the authors and especially to my supervisors @Vincent_Chaptal and Pierre Falson! #CryoEm #membraneproteins
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CryoEM of ATP-driven dynamics and itraconazole binding in a fungal ABC pump biorxiv.org/content/10.1101/… #biorxiv_biochem

CryoEM of ATP-driven dynamics and itraconazole binding in a fungal ABC pump

Azole resistance in Candida species often results from overexpression of the ABC transporter Cdr1, which expels drugs via ATP-driven conformational changes. Despite its clinical relevance, the...

biorxiv.org
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it's been a long time coming, and 2 fantastic PhD student (@AlexiaGobet and L.Moissonnier) to study the impact on ligands on the conformational spectrum of a multidrug ABC transporter. In the end, we understand how ligands trigger a cooperative ATP-binding
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Glad to have been part of the Open European Peroxisome Meeting, representing @GatsogiannisLab. And a Best poster prize for the #tomoteam ! #cryoEM #protein #Science – at Sant Feliu de Guíxols, Spain
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A really amazing talk from Pr. @yifan_ucsf, a pioneer of the 🔬❄️resolution revolution, and a pleasure to have had him as a guest at @GatsogiannisLab! #cryoEM
CheMTraP@CheMTraP_MS9 Oct 2024
We recently launched our seminar series for the #ChemTrap consortium (Topical Program @uni_muenster) with an amazing talk by @yifan_ucsf @UCSF on the structural studies of TRPV1 channel #cryoEM #resolution_revolution. Stay tuned for more updates!
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Well done to @GatsogiannisLab !! A cool story and even cooler structures! ❄️🔬
Gatsogiannis Lab@GatsogiannisLab7 Oct 2024
"Ever wondered how α-latrotoxin, the black widow spider's 🕷️ neurotoxin, turns into a cation-selective channel? Check out our latest manuscript! rdcu.be/dWez3 @NatureComms #Neuroscience #Toxin #cryoEM @Sfb1348 @uni_muenster
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📢New lab preprint: 2.05 A #cryoEM structure of UapA: unprecedented aspects of the elevator-type transport (incl. water, lipids) and regulatory roles of the N-tail. With Diallinas, Mikros labs. Kudos @broutzakis and all co-authors. @uni_muenster #SoN biorxiv.org/content/10.1101/…
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Céline Dion qui chante sur la Tour Eiffel, à jamais dans les souvenirs 🥹❤️ xitter.cf/CerfiaPlay/status/1816…
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With the team in front of the new CM02 microscope. Thanks for the private tour @SchoehnGuy and Lefteris. Can't wait to use the new toy!
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Really glad to have presented a part of my work on the 👑 of ABC transporters, Cdr1 during @FEBS_ABC2023 ! Great meeting, great people and great proteins! #science
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It all comes down to this! #JBCMethodsMadness CHAMPIONSHIP VOTE: #TeamMassSpec vs. #TeamCryo – Which method should be crowned champion?
49%Mass Spectrometry
51%Cryo–EM/ET
4,076 votes • Final results
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