Professor of Psychiatry & Neuroscience @MountSinaiNYC. Translational neuroscience, clinical trials & new treatments for mood and anxiety disorders.
New York, NY
Joined April 2015
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Looking forward to it!
Please join NYC-CBT for our upcoming panel on treatment-resistant disorders. For more information and to register visit: nyc-cbt.ce-go.com/test-19-04…
James Murrough retweeted
On latest episode of @PBS's "Healthy Minds", host Dr. Jeffrey Borenstein & @ScottRussoPhD discuss role of #Stress in illness, how lifestyle changes, including #Exercise, #Sleep, & #Diet, can help, & how monoclonal antibodies may help treat #MentalIllness.👉thirteen.org/programs/health…
James Murrough retweeted
Why do some people remain psychologically resilient after trauma, while others develop PTSD? A new study from Mount Sinai published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, points to a potential answer: how the brain anticipates positive experiences.
Researchers examined brain activity approximately two decades after 9/11 among World Trade Center rescue and recovery workers. Using fMRI, they found that highly resilient responders — those with substantial exposure to traumatic elements of the attacks — showed significantly stronger activity in brain regions involved in reward anticipation compared to both those with chronic PTSD and those with lower levels of WTC exposure.
The findings suggest that the brain's ability to detect and respond to positive information may help buffer the effects of trauma exposure, and point to potential new targets for PTSD treatment.
Learn more: mshs.co/4rkwXbK
@MountSinaiPsych @SinaiBrain
#PTSD #MentalHealth #Psychiatry #Resilience
Excited about this new paper from our group: 7T MRI of the locus coeruleus in #anxiety disorders, #PTSD, and healthy adults. The more anxious arousal, the stronger the LC–dACC coupling; diagnostic category showed no effect. My takeaway: Symptoms, not labels, map onto brain circuits. nature.com/articles/s41398-0…
James Murrough retweeted
Very grateful to be included in this stellar work, just published in @Nature . Very well done, Devon, Adeel and co! nature.com/articles/s41586-0…
Today at 12 PM ET — I’ll be speaking for the VISN 2 MIRECC webinar:
Rapid Advances in Depression Therapeutics: Ketamine, Psychedelics & Other Novel Approaches
Join via Microsoft Teams:
teams.microsoft.com/meet/283…
#Depression #Ketamine #Psychedelics #Psychiatry
James Murrough retweeted
We are pleased to announce that Drs. Yuan Cheng, Xuanming (David) Guo and @sarenseeley have been selected as recipients of the 2026 Robin Chemers Neustein Postdoctoral Fellowship Award. 👏Huge Congratulations Yuan, Xuanming and Saren ! 🎉 Learn More 👉 icahn.mssm.edu/education/pos…
James Murrough retweeted
Please see my new essay in Curr Opin Neurobiol that outlines exciting new opportunities to directly study the human brain and fundamentally advance basic, translational, and clinical neuroscience. @SinaiBrain @IcahnMountSinai pubmed.ncbi.nlm.nih.gov/4188…
James Murrough retweeted
Friendly reminder: Poster Submissions are open for the ACNP 65th Annual Meeting: January 10-13, 2027, San Diego, California. You must be registered for the meeting before you can submit a poster. The deadline to submit is August 27, 2026. #ACNP2027 tinyurl.com/43skzjvu
Check out our new protocol paper 🍇🧠! We designed a clinical trial testing for the first time whether a polyphenol-rich #natural product (BDPP) can boost #stress #resilience and testing absorption, inflammation, and response to a validated lab stress test. Early-phase work, big potential. w/ @Pasing01 @IcahnMountSinai @RutgersU. Results coming soon! Free article here: authors.elsevier.com/a/1nPTx…
James Murrough retweeted
Today, HHS launched a department-wide effort to restore U.S. leadership in clinical trials by reducing unnecessary barriers, accelerating research, expanding patient access to studies, and strengthening America’s biomedical innovation ecosystem.
From FDA and NIH to ARPA-H and ONC, HHS is working to help bring more clinical research, investment, and medical breakthroughs back to the United States.
Read More:
hhs.gov/press-room/hhs-launc…
James Murrough retweeted
In the latest JCP Podcast, Joseph Goldberg, MD — who led ASCP's 45-member deprescribing task force — argues that stopping a medication deserves the same rigor as starting one, with a simple framework: treat every drug like an employee due for a performance review. He covers when "treatment resistance" is really nonadherence, valproate in women of reproductive potential, the psychology of stopping, and hyperbolic tapering.
Listen here -----> podcasts.apple.com/us/podcas…
Sign up for our weekly email newsletter here -----> psychiatrist.com/register/es…
James Murrough retweeted
📝 Narrative Review: Low-dose #Lithium exposure is linked to neuroprotective effects, reduced #Dementia risk, and cognitive stabilization in mild cognitive impairment, supporting further clinical evaluation. ja.ma/4aFJIGC
James Murrough retweeted
Researchers @icahnmountsinai have ID'd distinctive patterns in how the brain transitions btwn activity states in people w/ #Depression, providing new insight into why depressive symptoms can feel persistent & difficult to overcome. PRESS RELEASE 👉 mountsinai.org/about/newsroo…
Excited to share this work from the amazing team at @IcahnMountSinai @MountSinaiNYC illuminating the brain dynamics underlying #depression. Major depressive disorder remains one of the leading causes of suffering worldwide. Our new work in @NatureComms uses advanced brain imaging and mathematical modeling to better understand how the depressed brain may become trapped in maladaptive patterns. The ultimate goal of our work is improving #antidepressant #treatment outcome patients.
CHECK OUT the FULL STUDY - "Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity" - @ulgenklc, Jenna Jubeir, Priti Balchandani, @JMurrough, Laurel S. Morris & Yael Jacob OUT NOW @NatureComms👉 nature.com/articles/s41467-0…
James Murrough retweeted
Really delighted to get copies of our new book, Elements of Functional Magnetic Resonance Imaging.
A labor of love over the past 10 years, along with @fmristats.
mitpress.mit.edu/97802620450…
James Murrough retweeted
Artificial intelligence is not replacing human intuition in maths and physics, but reimagining how questions are asked, explored and understood
go.nature.com/4vG4Vsl
James Murrough retweeted
Richard Friedman & James Tisch were honored at #MountSinai’s Crystal Party for their leadership & service. Richard Friedman’s visionary support established The #FriedmanBrainInstitute & helped drive advances in neuroscience research-We are incredibly grateful for his commitment!
James Murrough retweeted
Same problem is plaguing psychiatry, psychology, etc. A model may predictably describe a phenomenon, but that doesn’t mean that it has anything to do with the cause or mechanism of that phenomenon.
James Murrough retweeted
Among adults with treatment resistant #depression, single-day inhaled GH001 resulted in rapid, significant symptom reduction and remission vs placebo, with no severe adverse events and sustained effects over 6 months.
ja.ma/4er3MPj
