Really nice work out from Bagshi et al from the @blackwood_erik group. Ever wondered how patients exposed to #doxorubicin can have an increased risk of adverse events. This new paper gives us some important insights! #CardioOncology sciencedirect.com/science/ar…

ISHR World Congress abstracts are now published in JMCC Plus! 🎉 Showcasing global advances in cardiovascular research. sciencedirect.com/journal/jo…

Stuck between a ROCK2 and a hard place? New research just out shows selective ROCK2 inhibition reduces microvascular obstruction after myocardial I/R but doesn’t limit infarct size. Highlights distinct roles for ROCK isoforms in #cardioprotection. 🫀🔬 doi.org/10.1016/j.jmccpl.202…

🫀New research demonstrates that high-throughput, label-free optical oxygen measurements can assess adrenergic effects in iPSC-derived #cardiomyocytes. Paired with all-optical #electrophysiology, this enables scalable, human-based preclinical testing. doi.org/10.1016/j.jmccpl.202…

🫀🦠 How does #COVID19 damage the heart? New research from Gross et al. using human iPSC-derived #cardiomyocytes uncovers cellular responses to SARS-CoV-2, shedding light on mechanisms of cardiac injury. doi.org/10.1016/j.jmccpl.202…

💓 New research from Achlaug et al. @TechnionLive reveals how cancer-driven cytokine signalling improves cardiac function and reduces fibrosis. Tumour–heart crosstalk with major therapeutic implications doi.org/10.1016/j.jmccpl.202… #CardioOncology #Immunology #Fibrosis #Research

🚨 New paper alert! Feder et al. have recently shown that persistently increased #CaMKIIδ autophosphorylation drives pathological sarcoplasmic reticulum #calcium loss in a murine model of #doxorubicin-induced #cardiomyopathy. 💔➡️📉 Check it out: doi.org/10.1016/j.jmccpl.202…

Rab10 to the rescue! 🦸‍♂️🫀! New study from Xu et al. in the December issue shows how this tiny protein helps keep harmful heart growth in check. Read more at: doi.org/10.1016/j.jmccpl.202… #CardioProtection #Hypertrophy #CardioX @IshrMci @ISHR_ES @ISHR_NAS @ISHR_LAT @ISHR_AUS

🧪 Just out: a new #review of Rac1-driven signalling in cardiomyocytes — covering #hypertrophy, #arrhythmia and #redox stress. A must-read for anyone in cardiac research! 💙 #Cardiology #HeartResearch #SignalTransduction doi.org/10.1016/j.jmccpl.202…

Great new paper just out! Interested in how #insulin may promotes pro-inflammatory changes in the transcriptome of #atherosclerotic plaques? Check it out! @IshrMci @ISHR_ECI @ISHR_NAS @ISHR_ES @ISHR_LAT @JMCCardiology @ISHR_AUS

On your way to #AHA or just looking for some weekend reading? Check out the latest paper from Warren et al @thisisUIC who uncovered region-specific metabolic and signalling changes in the endocardium vs epicardium in a mini-pig model of #HCM 🫀🫀 sciencedirect.com/science/ar…

New work from Daoud et al. shows that removal of YAP/TAZ from vascular smooth muscle cells triggers inflammation and immune activation- indicating these factors as essential in vascular health.#vascularbiology sciencedirect.com/science/ar… @lunduniversity @JordanUni_Int @TU_Muenchen

We often treat #diabetes and #heart #disease separately — but they’re connected🫀. A recent study from Srinivas, Alluri et al. from @ODU shows that removing CHOP in β-cells protects against both metabolic dysfunction and cardiac fibrosis in T2D mice. sciencedirect.com/science/ar…

🫀 New in JMCC Plus! Age, sex & vessel region shape vasomotor function in the descending thoracic #aorta — with #endothelial integrity & relaxation declining with age. Want to know more- check out Saemann et al.: sciencedirect.com/science/ar… #VascularBiology

New work from @nicoleyorkova and the group of @dr_swayne charts how H9c2 heart cells change shape, signal, & express genes during differentiation—revealing both their promise & limits as #cardiomyocyte models. #CardioTwitter @JMCCardiology @LeighWicki sciencedirect.com/science/ar…

Ever wondered how #Calcium channels cluster in #iPSC derived #Cardiomyocytes? New work just published from Schwenzer et al. should put your mind at rest as they investigated just that! Check out the latest paper for more information sciencedirect.com/science/ar… @uniGoettingen

Looking for some weekend reading? 📜 New work from from the @HeartInstitute show how metabolic substrates regulate effects of Wnt/β-catenin signaling in #cardiomyocytes, specifically affecting regulation of #Connexin43 @WenbinLiang2 @PeterPLiu_MD sciencedirect.com/science/ar…