Promoting research and awareness of biological factors in order to prevent suicide and support mental health. #MindBodyConnect #CreateConnectContribute
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ALT Chronic psychosocial stress poses risk for physical & mood disorders, often associated with activated immune status and chronic low-grade inflammation. Studies show genetic (i.e. sex) & environmental (i.e. early life adversity or ELA) may increase stress vulnerability. ELA was induced via a maternal separation paradigm. CAS was induced in males through chronic subordination & 7-week exposure to social instability in females. Mice then received repeated s.c. administrations of Mycobacterium vaccae. For both sexes, ELA effects were to a great extent prevented by s.c. administrations. Male mice seem to be more susceptible to CAS than females & only females benefit slightly from stress-protective effects when given before CAS alone. Findings indicate that stress vulnerability during different life phases is strongly sex dependent & immunoregulatory approaches, such as repeated s.c. administrations of friendly bacteria have potential for treatment of stress-related disorders.
ALT Remember to register by 6/13 at VA TMS or TRAIN for free CEUs! SRM promotional image has a dark blue and lighter blue background with the presentation details in white and yellow text. It also features a headshot of Dr. Shiner.
