@JDHL18

Bioscience, Manchester Metropolitan University. Cell adhesion, proteomics, ECM. Tweets (not posts) mainly science.

 Manchester UK
scholar.google.co.uk/citations?hl=en&user=h9DWslsAAAAJ
Joined October 2009
  • Tweets22.3K
  • Following1K
  • Followers2.5K
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Have you commented on the handball for the penalty? @DaleJohnsonBBC Looked to be on the red part of this guideline
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We're particularly pleased to see recognition of Fellows who've contributed significantly to the Academy: 🔹Prof Jill Belch CBE - Founder Fellow 🔹 Prof Martin Humphries OBE - former VP who established our Regional Champions scheme 🔹 Prof Alan Boyd MBE - incoming Council member
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Replying to @DaleJohnsonBBC
@DaleJohnsonBBC can you comment on the lfc vs RM penalty VAR intervention?
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I mean the process. The ref gave a free kick. VAR intervention said it wasn't a penalty but that wasn't the refs decision.
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Very belatedly I've decided to pause posting here. You can find me and my posts where the skies are blue...
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#PLOSONE: THUMPD3 regulates alternative splicing of ECM transcripts in human lung cancer cells and promotes p ... dx.plos.org/10.1371/journal.…
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Targeting extracellular matrix stiffness for cancer therapy frontiersin.org/journals/imm…

Frontiers | Targeting extracellular matrix stiffness for cancer therapy

The physical characteristics of the tumor microenvironment (TME) include solid stress, interstitial fluid pressure, tissue stiffness and microarchitecture. A...

frontiersin.org
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FAK activity exacerbates disturbed flow-mediated atherosclerosis via VEGFR2-Cbl-NF-κB signaling biorxiv.org/content/10.1101/…

FAK activity exacerbates disturbed flow-mediated atherosclerosis via VEGFR2-Cbl-NF-κB signaling

Atherosclerosis develops at predictable sites in the vasculature where branch points and curvatures create non-laminar disturbed flow. This disturbed flow causes vascular inflammation by increased...

biorxiv.org
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FAK and p130Cas Modulate Stiffness-Mediated Early Transcription and Cellular Metabolism onlinelibrary.wiley.com/doi/…

FAK and p130Cas Modulate Stiffness‐Mediated Early Transcription and Cellular Metabolism

Cellular metabolism is influenced by the stiffness of the extracellular matrix. Focal adhesion kinase (FAK) and its binding partner, p130Cas, transmit biomechanical signals, such as substrate...

onlinelibrary.wiley.com
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ITGB4-Related pyloric atresia without epidermolysis in two siblings sciencedirect.com/science/ar…
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Emergence of the cell-matrix adhesion element ILK as a player in glioblastoma cell plasticity. sciencedirect.com/science/ar…
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Collagen signaling and matrix stiffness regulate multipotency in glandular epithelial stem cells in mice nature.com/articles/s41467-0…

Collagen signaling and matrix stiffness regulate multipotency in glandular epithelial stem cells in...

Nature Communications - The mechanisms regulating multipotency in glandular epithelia remain unclear. Here, the authors identify the key role of collagen signaling and ECM stiffness in regulating...

nature.com
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Review Integrins as Drug Targets in Vascular and Related Diseases sciltp.com/journals/ijddp/20…

Integrins as Drug Targets in Vascular and Related Diseases

Integrins are transmembrane receptors that, as critical participants in a vast range of pathological processes, are potential therapeutic targets. However, in only a few cases has the promise been...

sciltp.com
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JCI Insight - Talin1 dysfunction is genetically linked to systemic capillary leak syndrome insight.jci.org/articles/vie…
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This week the Guardian's owner, the Scott Trust, gifted the 233-year-old Observer to Tortoise Media. This isn't just a dark day for journalism, it's a sign. Meet the team. This is Putin giving Tortoise's energy advisory board member an 'Order of Friendship' medal in 2017. 1/
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FAK inhibition suppresses breast cancer progression via DNA methylation-mediated DAB2 gene reactivation biorxiv.org/content/10.1101/…

FAK inhibition suppresses breast cancer progression via DNA methylation-mediated DAB2 gene reacti...

Epigenetic silencing of tumor suppressor genes is one of the main drivers of tumor progression. Without these tumor suppressors to reduce proliferation, tumor cells proliferate unchecked. Focal...

biorxiv.org
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Jon Humphries retweeted
Becki Lee@BeckiLee20 Dec 2024
Our study recruiting now! Using ctdna to guide whether to have systemic treatment in early stage melanoma - amazing response from UK to get this q addressed- we already have 7 sites open in the first month and our first patient randomised! @CR_UK funded 🎉🎉
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