MD/PhD @GustaveRoussy, Hematologist #AML #Therapy related myeloid neoplasm #Clonal hematopoiesis #CHIP
Paris, France
Joined March 2023
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Jean-Baptiste Micol retweeted
🚀 Session III at #ESHAL26 continues!
This session featured an excellent presentation on the molecular insights into CHIP and AML in cancer survivors by Dr. @JB_Micol (Villejuif) followed by a lively panel discussion.
Chairs: Ibrahim Aldoss and @DrWendyStock
Jean-Baptiste Micol retweeted
Delighted to share our work on clonal hematopoiesis #CH out now in @NatureGenet. We revealed ancestry as a risk factor for CH 🧵
@ASTRAZENECAUK @Cambridge_Uni
nature.com/articles/s41588-0…
Jean-Baptiste Micol retweeted
Cette nouvelle étape reflète l'engagement de @GustaveRoussy à toujours placer nos #patients au coeur de nos priorités et à renforcer notre mission de #soins et d'#innovation pour tous. Le progrès, c'est aussi rendre la santé plus accessible !
La station de métro Villejuif - Gustave Roussy de la @Ligne14_RATP a ouvert ses portes aujourd'hui !
Plus qu'une #station, c'est un lien direct qui rapproche des milliers de personnes des soins, de l'innovation et de la recherche.
Jean-Baptiste Micol retweeted
Cancer survivors are growing in number. In the US, nearly half of survivors have lived 10 or more years after diagnosis, while 19% have lived 20 or more years. The prevalence of long-term survivors is expected to increase through 2040. go.nih.gov/rOUbZJD #CancerSurvivorship
ALT Stacked line graph of cancer survivorship rates.
Jean-Baptiste Micol retweeted
Read this study by Dawi et al regarding tumor fraction liquid biopsy performed for tumor burden assessment and how well it correlated with total tumor volume at CT. bit.ly/3VaG93o
Jean-Baptiste Micol retweeted
Huge work of @GustaveRoussy Radiology Department and MTB: "Liquid Biopsy versus CT: Comparison of Tumor Burden Quantification in 1065 Patients with Metastases".
📌Article: doi.org/10.1148/radiol.23267…
📌Editorial: doi.org/10.1148/radiol.24252…
Read this study by Dawi et al regarding tumor fraction liquid biopsy performed for tumor burden assessment and how well it correlated with total tumor volume at CT. bit.ly/3VaG93o
Jean-Baptiste Micol retweeted
A nice commentary in this issue of @BloodJournal for our paper looking at the role of #ClonalHematopoiesis in #TBD from @Chris_R_Reilly and @myllymaki_mikko - a somatic symphony; telomeres and CH! ashpublications.org/blood/ar… @fergutierrezro1 @SharonSavageMD ashpublications.org/blood/ar…
Jean-Baptiste Micol retweeted
Congrats to our PhD student, @Debureaux_PE and all co-authors for this collaborative work performed with Saint Louis, Cochin, Pitié Salpétrière, Lille, Necker, Mondor and Avicenne hospital on Inflammatory Waldenstrom and Clonal hematopoiesis paper published in Blood Journal!
Jean-Baptiste Micol retweeted
I’m very thrilled to presented our work at ASH 2024 Congress, 07/12/24, 5.30-7.30 pm.
Clonal Hematopoiesis and Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors an association to watch !
A big thanks to the whole participated centers and to @JB_Micol
#ASH2024
Jean-Baptiste Micol retweeted
Out in @BloodJournal today, @alyssa_c_parker developed an accurate way to monitor clonal dynamics in #CHIP that makes short term changes in clone size a reliable readout for clinical trials. @VUMCgenetics @VUMCDiscoveries 👇
Is DNA sequencing sufficient for monitoring progression of clonal hematopoiesis? We present a novel DNA methylation sequencing assay that captures blood cell composition! 🩸 @BloodJournal @AlexBickMDPhD 🧵1/12
Jean-Baptiste Micol retweeted
Sad as yet another randomized, Phase 3 Trial in higher-risk #MDSsm - this one of AZA + Tamibarotene vs AZA alone with RARA+ - fails. We need to power these adequately to show incremental overall survival improvement, and not focus on CR! ☹️🩸😡 ir.syros.com/press-releases/…
Jean-Baptiste Micol retweeted
Out in print! Risk prediction for clonal cytopenia: multicenter real-world evidence | Blood | American Society of Hematology | Proud to have contributed to this multicenter collaboration!@SylvesterCancer #CCUS #MDSsm #leusm #hematology ashpublications.org/blood/ar…
Happy to share our article on lenalidomide-associated Acute Lymphoblastic Leukemia. We hope that it may help the physicians to better monitor this risk.
nature.com/articles/s41408-0…
Jean-Baptiste Micol retweeted
The Olympic flame today
@GustaveRoussy
carried by a young cured patient, relayed by two staff members, symbolizing the flame that drives staff, doctors & researchers in the service of patients living with #cancer #1⃣ in Europe
🙏@valdemarne_94
@VilleVillejuif @Paris2024_JO
Jean-Baptiste Micol retweeted
How does clonal haematopoiesis evolve to leukaemia (AML)?🩸How long does it take?⏳
⭐️Excited to share our preprint!⭐️ Using serial blood samples collected BEFORE diagnosis of AML we unveil the somatic evolution📈 that occurs in the decades pre-diagnosis: biorxiv.org/content/10.1101/…
Jean-Baptiste Micol retweeted
🎓 Félicitations aux cinq lauréats des concours CNRS/Inserm
Chaque année, le @CNRS et l’@Inserm organisent des concours très sélectifs pour recruter leurs nouveaux chercheurs titulaires. Cette année, parmi les cinq lauréats pour @GustaveRoussy, quatre mènent déjà des recherches à l'Institut. Le cinquième, actuellement post-doctorant aux National Institutes of Health aux États-Unis, a reçu en parallèle le prestigieux financement ATIP-Avenir pour monter son équipe à Gustave Roussy et y développer ses travaux de recherche.
🔹Brahim Arkoun
🔹Antonin Marchais
🔹Gabriel Matos Rodrigues
🔹Lydia Meziani
🔹Florent Peglion
En savoir plus ➡ gustaveroussy.fr/fr/news-fel…
Jean-Baptiste Micol retweeted
What better way 2 begin the academic year than 2 learn the “16+2” molecular subgroups of #MDSsm …. Never a better time to be a #hematopathologist 🎉
Going frm 3 genetically defined groups (multi TP53, SF3B1 and del 5q) of MDS to 16 👇🏼is a major advancement in our understanding of MDS biology 💡
🙏🏻 and congratulations @Elsa2Bernard @PapaemmanuilLab and everyone involved for this beautiful and clinically important work!
@BloodJournal @ASH_hematology
#hemepath
ashpublications.org/blood/ar…
Jean-Baptiste Micol retweeted
Out in @NatureAging today, @taralynn_mack & @MichaelR21 identify epigenetic and proteomic signatures associated with #CHIP clonal expansion nature.com/articles/s43587-0…
Jean-Baptiste Micol retweeted
CONGRESS | #ASCO24
Alexandre Bazinet @MDAndersonNews demonstrated that, in unfit patients with ND AML, 7-day courses of HMA-Ven were associated with similar CRc rates, and potentially less myelosuppression and early mortality, vs standard dosing. Prognostic risk signature appeared to impact survival, with OS improved in patients without FLT3-ITD, N/KRAS or TP53 mutations treated with standard dosing.
#AMLsm #leusm
Jean-Baptiste Micol retweeted
Happy to share our article on Clonal Hematopoiesis in phase I patients.
⚠️Prevalence of 41%
No impact on OS, slight PFS benefit with targeted therapies
No major toxicity
@CapuBaldini
@GustaveRoussy
doi.org/10.1200/PO.23.00631
