@IvanovLab

Research team studying myeloid cell diversity, functions and metabolism. @LP2M_lab

 Nice, France
Joined December 2024
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Excited to share the lab's first preprint ! We previously observed CD226+ macrophages in brown fat that resemble CCR2- and IRF4-dependent peritoneal small Macs, but we didn't know anything about them... biorxiv.org/content/10.1101/…

CD226+ adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism

Macrophages are innate immune cells present in all tissues, in which they participate in immune responses and maintenance of tissue homeostasis. They develop either from embryonic precursors or from...

biorxiv.org
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Happy to share our recent review on CD226+ mononuclear phagocytes, published in Trends Open! We share our opinion on the peculiar phenotype of these cells, that share common features with both dendritic cells and macrophages. @LP2M_Lab @CNRS_DR20 cell.com/trends-open/fulltex…
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@Univ_CotedAzur @Inserm
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Happy to see this paper out @NatImmunol ! To read it : rdcu.be/eX0JB Great collaboration with the Becher lab @UZH_en. @AlexGallerand @LP2M_Lab @Univ_CotedAzur @CNRS_DR20
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This novel macrophage population in salivary glands is regulated by ILC-2 derived GM-CSF and arises mostly from MDP-derived monocytes. Importantly, they also express CD226+ and have a lot in common with the population we describe in adipose tissue... More to come !
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CSF1R regulates monocyte subset differentiation and intracellular metabolism. biorxiv.org/content/10.1101/… Our new preprint is now online ! Here, we explore links between CSF1R signalling, intracellular metabolism and monocyte differentiation.@LP2M_Lab @Cnrs20 @Univ_CotedAzur @Inserm

CSF1R regulates monocyte subset differentiation and intracellular metabolism

Monocytes are key circulating effectors of vascular homeostasis, innate immunity and inflammation. Following their generation in mouse bone marrow, classical (Ly6Chigh) monocytes are mobilized into...

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We report that surface CSF1R expression relies on continuous translation and export to the membrane. CSF1R recycling rate accelerates as monocytes differentiate from the Ly6Chigh to the Ly6Clow subset, and CSF1R blockade prevents Ly6Chigh commitment towards this trajectory.
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CSF1R signalling sustains glucose uptake in Ly6Chigh monocytes to fuel the hexosamine biosynthetic pathway (HBP), which in turn allows optimal CSF1R expression. Impairing glucose flux towards HBP through GFPT1 invalidation leads to increased Ly6Chigh/Ly6Clow ratio.
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nature.com/articles/s42003-0… A great work by the Williams lab! Thank you for the collaboration. More to come :) @Lab__Williams @LP2M_Lab @CNRSbiologie @Cnrs20 @Inserm @Univ_CotedAzur

Identification of conserved and tissue-restricted transcriptional profiles for lipid associated...

Communications Biology - Transcriptional analysis of lipid associated macrophages across chronic inflammatory diseases and tissues reveals shared and tissue-restricted gene expression programs.

nature.com
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Congrats @LettieriBarbato and team for their recent publication on brown adipose tissue macrophages, happy to have been involved in the project ! @LP2M_Lab @CNRSbiologie @Univ_CotedAzur @Lab__Williams nature.com/articles/s41467-0…

MACanalyzeR scRNAseq analysis tool reveals PPARγHIGH/GDF15HIGH lipid-associated macrophages...

Nature Communications - The homeostasis and function of adipose tissue are tightly regulated by immune cells, with macrophages playing a pivotal role. Here the authors show that PpargHIGH...

nature.com
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Ivanov lab retweeted
Ivanov lab@IvanovLab6 Dec 2024
Excited to share the lab's first preprint ! We previously observed CD226+ macrophages in brown fat that resemble CCR2- and IRF4-dependent peritoneal small Macs, but we didn't know anything about them... biorxiv.org/content/10.1101/…

CD226+ adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism

Macrophages are innate immune cells present in all tissues, in which they participate in immune responses and maintenance of tissue homeostasis. They develop either from embryonic precursors or from...

biorxiv.org
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Happy to see this study published in @HEP_Journal, resulting from a great collaboration with Philippe Gual @C3M_U1065 @LP2M_Lab @CNRS_DR20 @Inserm @Univ_CotedAzur with contribution from @Lab__Williams @AlexGallerand @Bastien_Dolfi journals.lww.com/hep/abstrac…
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We report that this subset is conserved across several tissues and especially fat, in which they regulate lipid metabolism. Importantly, these cells have a rapid turnover from monocytes, and in particular MDP-derived monocytes that are biased to differentiate into CD226+ Macs !
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Thanks to team members and key collaborators @AlexGallerand @adeline_bertola @maxim_artyomov @Bastien_Dolfi @DavidMASSON14 @FGinhoux @lab_mass @Lab__Williams and all other people involved !
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Happy to see our review on macrophages of the vascular system published in Nature Cardiovascular Research ! ⁦@GwenRandolph_⁩ ⁦@jichang_han⁩ @IvanovLab nature.com/articles/s44161-0…
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🚨preprint alert! Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages (LAMs) biorxiv.org/content/10.1101/…

Identification of conserved and tissue-restricted transcriptional profiles for lipid associated...

Macrophages are essential immune cells present in all tissues, and are vital for maintaining tissue homeostasis, immune surveillance, and immune responses. Considerable efforts have identified shared...

biorxiv.org
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Ivanov lab paper ! Very happy to see our story on monocyte glucose metabolism online in ⁦@NatureComms⁩ today. Inhibition of Glut1 depletes the majority of blood monocytes, yet atherosclerotic plaques still develop normally🧐 ⁦⁦@LP2M_Lab⁩ nature.com/articles/s41467-0…

Glucose metabolism controls monocyte homeostasis and migration but has no impact on atherosclerosis...

Nature Communications - Monocytes participate in plaque formation, and adapt to metabolic changes to alter their functions. Here the authors show, using genetic mouse models and functional...

nature.com
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Happy to see this story out! @LP2M_Lab @Univ_CotedAzur @CNRS_DR20 @Bastien_Dolfi @AlexGallerand Sex‐specific impact of psychosocial stress on hematopoiesis and blood leukocytes - Dolfi - European Journal of Immunology - Wiley Online Library onlinelibrary.wiley.com/doi/…

Sex‐specific impact of psychosocial stress on hematopoiesis and blood leukocytes

Chronic stress and sex hormones influence innate and adaptive responses. Our study found that chronic psychosocial stress increases lymphocytes in both sexes, while myelopoiesis is increased in an...

onlinelibrary.wiley.com
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Glad to share our new study investigating the unknown diversity of adrenal glands macrophages. I would like to thanks all my team and collaborators for this incredible work ! cell.com/cell-reports/fullte…

Unravelling the sex-specific diversity and functions of adrenal gland macrophages

Dolfi et al. uncover the sex-specific heterogeneity of adrenal gland macrophages and their ontogeny, maintenance, tissue distribution, and role in local lipid homeostasis.

cell.com
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