Bioengineering to unlock new possibilities | Formerly PhD @MITdeptofBE (Birnbaum Lab) with a minor (major) virus obsession
Cambridge, MA
Joined October 2011
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It’s hard not to get addicted to this.
From side conversations with @MEBirnbaum to an incredible result for patients. So proud of the Kelonia team for all the hard work it took to make this real.
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These are the days that make the long hours worth it. Excited to see a technology I invented take this big step toward benefitting patients.
Grateful to the whole team at Kelonia for building what was once just cool tech into a real drug that could bring CAR-T to everyone.
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Excited to see some movement on understanding the human thymus, and for everything @BrookeHuisman will build on from here 🚀
Thrilled to share our study, online today @ImmunityCP : thymic mimetic cells are evolutionarily ancient, with conserved and species-specific elements in humans, zebrafish, and mice. cell.com/immunity/abstract/S… 1/n
Connor Dobson retweeted
Peptide-MHC-targeted retroviruses enable in vivo expansion and gene delivery to tumor-specific T cells biorxiv.org/cgi/content/shor… #biorxiv_immuno
Connor Dobson retweeted
Um..🤯. Freeze dried tissue preserves chromatin for centuries!
“…we dehydrated the tissue first. The architecture was fine….Ran over it with a car, had a former Astros starting pitcher throw a fastball at it, fired a shotgun at it. Still fine.”
It’s finally out! 🥳 Today @cellcellpress we report non-mineral fossils of ancient chromosomes in skin from a woolly mammoth that died in Siberia, 52,000 years ago.
🦣💨
Don’t miss our thread below! 🧵👇🏽
Lots of good answers to this, but for me it has to be high-quality single-molecule protein sequencing methods. From basic science to the clinic, there’s so much we could learn from knowing what’s going on at the protein level in and out of cells
It’s been really cool to see the confluence of technology development and molecular insights that have enabled such detailed studies of viral molecules directly on viruses, performed safely and efficiently. Can’t wait for future progress in this space
In new study led by @bdadonaite, we measure how all mutations to H5 influenza HA affect four molecular phenotypes relevant to pandemic risk:
biorxiv.org/content/10.1101/…
Results can inform surveillance of ongoing evolution of H5N1.
Connor Dobson retweeted
Excited to share some of my PhD work was pre-printed! Using single-cell sequencing, we took a deep look at a library of CAR signaling architectures to try to identify signal-intrinsic drivers of CAR-T function🧵👇 @MEBirnbaum @kochinstitute @MITdeptofBE
biorxiv.org/content/10.1101/…
Connor Dobson retweeted
Library-based single-cell analysis of CAR signaling reveals drivers of in vivo persistence biorxiv.org/cgi/content/shor… #biorxiv_immuno
Connor Dobson retweeted
Pooled screening for CAR function identifies novel IL13Rα2-targeted CARs for treatment of glioblastoma biorxiv.org/cgi/content/shor… #biorxiv_immuno
Connor Dobson retweeted
There’s a frequent perception among recent entrants to drug discovery world that if we could just find drug candidates faster, this will be a useful accelerant to the overall process. The issue is: this thinking is mostly (but not entirely) incorrect. 🧵 1/
Can confirm - I used to get off the T early because it was faster to walk… What doesn’t make the headline is that wait times were often 10-15 minutes before getting on a standing room only train going slower than walking speed
Tracks that opened for passenger service to Union Square in March 2022 and to Medford in December — and were shut down for repairs in recent months — are now so defective, the @MBTA says, that trains are moving slower than many people walk. bostonglobe.com/2023/09/26/m… via @taydolven
Connor Dobson retweeted
More healthcare gold. Now how to drive reforms that do away with this dark humor. @NPLB_org
How I know DC is home now: I ordered a tea and was brought a beverage sweeter than any soft drink on the menu. This is the correct response and I will not be taking questions at this time
Connor Dobson retweeted
#ASGCT2023 News: @KeloniaTx Lentiviral Particles May Solve In Vivo Delivery Hurdles for CAR T Cells genengnews.com/gen-edge/asgc… via @GENbio
Excited to attend #ASGCT23 next week with the @KeloniaTx crew! Please reach out if you’d like to meet up
Incredibly proud to be a part of this team!
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Connor Dobson retweeted
Excited to share recently published work with @KelseyMWheeler and a great team looking into how mucins influence oral microbial communities!
One of the many pros of living with @chloemwu is that I now have a surprisingly deep appreciation for mucus. Read all about how mucins affect our oral microbiomes in her recently published paper! :)
nature.com/articles/s41522-0…
