@IsbBonn

We are interested in structure-function relationships of biological macromolecules.

Joined October 2020
  • Tweets171
  • Following101
  • Followers167
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Was great to contribute to this story together with @JanGerhartz @dpienkowska9 Ina Dressel & Thomas Geiger from the lab. #CRBN #Interactome #GLUES @CellChemBiol @EnamineGermany @iDikic2 @merckgroup @ibetportugal @MPIbp Animation credit @proxidrugs Paper: authors.elsevier.com/sd/arti…
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Congratulations @NielsSchneberg1 what a way to finish a PhD! With @sc_binder @PhilippHendr @MartinPeter91 @PAKoenig @GavinHThomas @SMenzel @PAKoenig @GavinHThomas & Gregor Hageleuken! #Nanobodies #TRAP.
Niels Schneberger@NielsSchneberg123 Nov 2024
We found a #VHH antibody that allosterically inhibits sialic acid binding by the #TRAP transporter #SBP VcSiaP. Thanks to the team @PhilippHendr @MartinPeter91 @sc_binder @PAKoenig @SMenzel @ @GavinHThomas @GHagelueken Read the full story here: doi.org/10.1038/s42003-024-0…

Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein

Communications Biology - Biophysical and structural characterization of the TRAP transporter SBP SiaP in complex with a nanobody provides insights into an allosteric mechanism of inhibition.

nature.com
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We found a #VHH antibody that allosterically inhibits sialic acid binding by the #TRAP transporter #SBP VcSiaP. Thanks to the team @PhilippHendr @MartinPeter91 @sc_binder @PAKoenig @SMenzel @ @GavinHThomas @GHagelueken Read the full story here: doi.org/10.1038/s42003-024-0…

Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein

Communications Biology - Biophysical and structural characterization of the TRAP transporter SBP SiaP in complex with a nanobody provides insights into an allosteric mechanism of inhibition.

nature.com
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Had to get one for the lab. #Falcon your falcon! Printed by @gha14 Instructions: thingiverse.com/thing:273887…
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We are hiring! Looking for a #postdoc to join the team in the Nowak Lab to focus on chemical biology in cells and recombinant systems. Excited about protein degradation, small molecule proximity? get in touch! #TPD #InducedProximity #ChemicalBiology nowak-lab.com/

Nowak Lab | University of Bonn

The Nowak Lab at the Institute of Structural Biology, University of Bonn, studies targeted protein degradation and small molecule induced proximity to engineer the cellular interactome.

nowak-lab.com
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Congratulations to @JanGerhartz for this nice piece! Go go Jan! #KEAP1 #InducedProximity
Jan Gerhartz@JanGerhartz20 Jun 2024
It was a lot of fun to writhe the preview perspective article: “A Double Whammy for KEAP1”. Discover the bivalent mechanism affecting KEAP1 and their implications for future small molecules. #FirstPaperFromTheLab #Science #KEAP1 #Biology #NewPublication sciencedirect.com/science/ar…
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It was a lot of fun to writhe the preview perspective article: “A Double Whammy for KEAP1”. Discover the bivalent mechanism affecting KEAP1 and their implications for future small molecules. #FirstPaperFromTheLab #Science #KEAP1 #Biology #NewPublication sciencedirect.com/science/ar…
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We are #hiring! We have an open #postdoctoral position in my group with the focus on structural biology #cryoEM and X-ray crystallography of new #E3 ligases as well as #molecularglue complexes. @UniBonn @IsbBonn nowak-lab.com/ Please RT!

Nowak Lab | University of Bonn

The Nowak Lab at the Institute of Structural Biology, University of Bonn, studies targeted protein degradation and small molecule induced proximity to engineer the cellular interactome.

nowak-lab.com
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Welcome Ina and Dominika!
Radek Nowak@RPNowak3 May 2024
Great to have Dominika Pieńkowska and Ina Dressel join the Nowak lab! Dominika started her Master's project with us and Ina joined as a lab manager. BelatedTwitter welcome Dominika and Ina! @JanGerhartz #GoTeam #TPD #NewPI @UniBonn @UniklinikBonn @IsbBonn nowak-lab.com/

Nowak Lab | University of Bonn

The Nowak Lab at the Institute of Structural Biology, University of Bonn, studies targeted protein degradation and small molecule induced proximity to engineer the cellular interactome.

nowak-lab.com
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Great to have Dominika Pieńkowska and Ina Dressel join the Nowak lab! Dominika started her Master's project with us and Ina joined as a lab manager. BelatedTwitter welcome Dominika and Ina! @JanGerhartz #GoTeam #TPD #NewPI @UniBonn @UniklinikBonn @IsbBonn nowak-lab.com/

Nowak Lab | University of Bonn

The Nowak Lab at the Institute of Structural Biology, University of Bonn, studies targeted protein degradation and small molecule induced proximity to engineer the cellular interactome.

nowak-lab.com
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Targeted protein #degradation: from mechanisms to #clinic. New molecular mechanisms can rapidly be translated - we can learn so much from nature. Great to be able to share this piece with @jonathanMtsai Ben Ebert and Eric Fischer @fischerlab1. #TPD nature.com/articles/s41580-0…
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Huge congrats to our amazing colleague @IsabellJamitzky for winning the GBM Master Thesis Award! Absolutely deserved for her incredible work on investigating Gasdermin D. She wrote a small post about her journey: network.febs.org/posts/findi… Thanks!! @Buelow_Lab @FEBSnews @GBM_eV

Finding biochemistry – The journey so far

From realising a preference for researching the fundamentals of life, to receiving the GBM Master Thesis Award and embarking on a PhD exploring the structure and function of inflammasomal proteins,...

network.febs.org
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Big congratulations to our dynamic trio @PhilippHendr @MaxSticks7 @NielsSchneberg1 for their outstanding talks and thanks for the following insightful discussions with the audience! 🎉👏 #DGK2024
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Congratulations to Dr. @InesKalt for successfully defending her PhD thesis! 🎓 We wish you all the best for your journey in Oxford. We will miss you in our lab and especially in the CDK family.🧬
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We are happy to announce that our team member Dominic Ferber has received a doctoral scholarship from the @studienstiftung! Great support for his PhD research. Congratulations! – at Bonn, Germany
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NEWS! I'm excited to share that I'm joining @IsbBonn @UniklinikBonn @UniBonn @ImmunoSens as a professor to start my LAB! We are open for business and #hiring for #postdoc #tech positions! #NewPI #MoveToGermany #UniBonn #TPD #InducedProximity Please share! nowak-lab.com

Nowak Lab | University of Bonn

The Nowak Lab at the Institute of Structural Biology, University of Bonn, studies targeted protein degradation and small molecule induced proximity to engineer the cellular interactome.

nowak-lab.com
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Excited about #TPD and #InducedProximity? So are we, and we are recruiting! #postdoc #technician #NowakLab #Germany @UniBonn @UniklinikBonn @ImmunoSens Please DM or reach us on nowak-lab.com/

Nowak Lab | University of Bonn

The Nowak Lab at the Institute of Structural Biology, University of Bonn, studies targeted protein degradation and small molecule induced proximity to engineer the cellular interactome.

nowak-lab.com
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New in JBC press: "Scientists' results provide the basis for a rational improvement of SR-4835 towards Cdk12 inhibition and a gain in selectivity over other transcription regulating CDKs." Learn more: jbc.org/article/S0021-9258(2…
Figure 2. Crystal structure of Cdk12•SR-4835/CycK complex.

ALT Figure 2. Crystal structure of Cdk12•SR-4835/CycK complex.

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📢 We are #hiring! 🥼 We’re looking for a #postdoc to work on an exciting, collaborative project between myself & @eickelatz at the @IIIBonn and @DZNE_en in Bonn, Germany! #job @ImmunoSens @UniklinikBonn karriereamukb.de/offer/postd…
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🤩Great to host Matthias Geyer from the University of Bonn as a guest speaker in the upcoming Gene Center Seminar. Welcome Matthias!🤗 He will give a seminar on his recent groundbreaking work on the structures of inflammasome complexes. ➡️ Lynen Lecture Hall 📅December 11 🕐1 pm
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