@IsabelWassing

DPhil in Molecular Cell Biology in Health and Disease (University of Oxford), Postdoc at the Rockefeller University

Joined June 2020
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Here is the link to a news letter article covering our finding. xitter.cf/RockefellerUniv/status…
Rockefeller University@RockefellerUniv23 Aug 2024
New from @HironoriFunabi1's lab: CDCA7, whose mutations alter DNA methylation pattern and cause immunodeficiency, is a novel sensor for a special class of methylated DNA. #RockefellerScience rockefeller.edu/news/36393-n…
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Excited to share the revised version with a new title "CDCA7 is an evolutionarily conserved hemimethylated DNA sensor in eukaryotes" now published @ScienceAdvances! Congrats @IsabelWassing, @QingyuanJia, @NishiyamaAtsuya, @KyoheiArita! science.org/doi/10.1126/scia…
Hironori Funabiki@HironoriFunabi120 Dec 2023
New preprint from the lab led my talented postdoc @IsabelWassing! She discovered that CDCA7's unique zf-4CXXC_R1 domain acts as a novel hemi-methylated DNA binding module to recruit the nucleosome remodeler HELLS and help DNA methylation! Check out her tutorial!
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Isabel Wassing retweeted
Yasuhiro Arimura@ArmrYshr21 Feb 2024
Please repost! Arimura Lab is hiring! We are seeking the next generation of MagICians (technicians and a postdoc) to elucidate the structural basis of events on chromosomes🧙‍♀️ No prior structural biology experience is required!! Link research.fredhutch.org/arimu…

Join the Lab

Opportunities available at the Arimura Lab at Fred Hutchinson Cancer Center.

research.fredhutch.org
Yasuhiro Arimura@ArmrYshr22 Jan 2024
Magnetic Isolation and Concentration (MagIC)-cryo-EM is a new method to enable direct structural analysis of targets captured on nanomagnetic beads, which requires only 0.0005 mg/mL of targets in 100 µL crude solution to make 10 cryo-EM grids. I will explain the magic behind it!
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Isabel Wassing retweeted
Yasuhiro Arimura@ArmrYshr22 Jan 2024
Excited to share my final PostDoc work! Introducing MagIC-cryo-EM🪄 & DuSTER🧹, these methods reduce cryo-EM sample requirements (0.0005 mg/mL), enabling ALL biologists to explore the structural basis of diverse biological events! BioRxiv: biorxiv.org/content/10.1101/…

Cryo-EM analysis on magnetic beads for scarce macromolecules in heterogeneous samples

Here, we introduce Magnetic Isolation and Concentration (MagIC)-cryo-EM, a technique enabling direct structural analysis of targets captured on nanomagnetic beads, thereby reducing the targets’...

biorxiv.org
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Very excited to announce our pre-print! Together with the labs of @NishiyamaAtsuya and @KyoheiArita, we’ve discovered that the protein CDCA7 (a long-time favourite in the Funabiki lab) exhibits a striking ability to sense hemi-methylated DNA. 1/7 biorxiv.org/content/10.1101/…

CDCA7 is a hemimethylated DNA adaptor for the nucleosome remodeler HELLS

Mutations of the SNF2 family ATPase HELLS and its activator CDCA7 cause immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome, characterized by hypomethylation at heterochromatin....

biorxiv.org
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…saw the specific accumulation of CDCA7 on hemi-methylated DNA, which also recruits HELLS. Suddenly, the unique role of the CDCA7-HELLS nucleosome remodeler in DNA methylation starts to make more sense. As always, several intriguing questions remain. 6/7
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We’re excited to investigate the ways in which the recognition of hemi-methylated CpG by CDCA7 may differ from its recognition by UHRF1. Currently having fun thinking about the potential roles of a hemi-methylation sensor… better get back to the bench! @HironoriFunabi1 7/7
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