Haemochromatosis International

ALT A figure with two panels. Panel 1 shows the linear association between iron polygenic score and six outcomes. There were significant associations between any liver disease, and separately with liver fibrosis or cirrhosis, and liver cancer. The associations with osteoarthritis and diabetes were not statistically significant but the effects were in the direction consistent with the hypothesis that iron increases risk in C282Y homozygous males. Panel 2 shows a more detailed analysis of liver fibrosis or cirrhosis, where the polygenic score is split into five groups (quintiles). The risk of liver fibrosis or cirrhosis increases across the quintiles.