📚 New Allergy & Immunology Trial Files Throwback! 💉 Icatibant accelerated symptom relief in HAE 🩺 Omalizumab improved chronic urticaria symptoms 🧴 Tezepelumab showed no significant benefit in atopic dermatitis 🔗 allergyimmtrialfiles.substac… #Allergy #Immunology #MedTwitter

💭 What would YOU ask about reducing low-value care? We’re recording a LIVE Medicine Pods podcast with Dr. Silverstein at #CSIM2026, and we want your questions! Drop yours below 👇 We may ask it during the live recording! 🎙️ 📅 Oct 23 | 7:55–9 AM @WKSilverstein @CSIMSCMI

📚 New Heme Onc Trial Files! 💊 Indefinite lenalidomide offered no survival benefit vs. 2 years 🧬 Mezigdomide-Kd improved PFS in relapsed MM 🎯 Pirtobrutinib + VenR improved PFS in relapsed CLL 🔗 hemeonctrialfiles.substack.c… #HemeOnc #MedTwitter

📚 New Thrombo Trial Files Throwback! 🩸 DOACs were noninferior to LMWH for cancer-associated VTE 💊 Rivaroxaban showed similar efficacy, but noninferiority was unproven ⚖️ SELECT-D: Less VTE, more bleeding with rivaroxaban 🔗 thrombotrialfiles.substack.c… #Thrombosis #MedTwitter

🎙️ Medicine Pods is going LIVE at #CSIM2026! Join us for a live podcast with Dr. William Silverstein: Teaching Wisely: Leveraging Education to Reduce Low-Value Care on General Medical Wards 📅 Oct 23 | 7:55–9 AM Have a question? Drop it below! 👇 @WKSilverstein @CSIMSCMI

📚New Critical Care Trial Files! 🫁Conservative oxygen offered no benefit after cardiac arrest 💉Sodium bicarbonate did not improve ROSC 🧠Selective brain cooling was safe & feasible in a pilot trial 🔗Read the issue: criticalcaretrialfiles.subst… #CriticalCare #MedTwitter #FOAMed

📚 New Cardio Trial Files! ❤️ Mavacamten reduced LVOT gradients in adolescent HOCM 💊 Enlicitide lowered LDL-C by 64.6%, outperforming other oral nonstatins ⚖️ Weight loss did not improve AFib symptoms in LOSE-AF 🔗 cardiotrialfiles.substack.co… #Cardiology #MedTwitter

📬 Stay in the Loop with Medicine Pods! Sign up for our monthly newsletter at medicinepods.com to get the latest podcast episodes and medical infographics, delivered straight to your inbox! #MedEd #MedTwitter

📚 New IBD Trial Files! 🏠 Proactive home fecal calprotectin monitoring did not prevent UC flares 💉 Anti-TNF withdrawal led to more flares than continued therapy (52% vs. 12%) 🔗 ibdtrialfiles.substack.com/p… #IBD #UlcerativeColitis #MedTwitter

📚 New Trial Files Throwback! 🫁 5 days of prednisone was enough for COPD exacerbations 💧 Balanced crystalloids reduced adverse kidney events vs saline 🫘 Canagliflozin improved renal outcomes in T2DM + CKD 🔗 trialfiles.substack.com/p/tr… #MedTwitter #TrialFiles

📚 New AllergyImm Trial Files! 🎨 Upadacitinib ↑ repigmentation in vitiligo 💇 Deuruxolitinib ↑ hair regrowth in alopecia areata 🧴 Lebrikizumab was effective in atopic dermatitis regardless of atopic comorbidities 🔗 allergyimmtrialfiles.substac… #Allergy #Immunology #MedTwitter

📚New Heme Onc Trial Files! 🧬Tafa-len-R-CHOP improved PFS in high-risk DLBCL 💊Pirtobrutinib outperformed ibrutinib in CLL/SLL 🎯Pola-R-GemOx improved survival in relapsed DLBCL 🔗hemeonctrialfiles.substack.c… #HemeOnc #MedTwitter

📚New Thrombo Trial Files! 🫁YEARS safely ↓ CTPA use in cancer patients 💉Intermediate-dose heparin offered no benefit in critical COVID-19 🦵Aspirin alone was noninferior for VTE prevention after hip/knee arthroplasty 🔗thrombotrialfiles.substack.c… #Thrombosis #VTE #MedTwitter

📚 New Diabetes Trial Files! 💊 Oral orforglipron outperformed dapagliflozin for HbA1c reduction 💉 CagriSema improved HbA1c & weight without more hypoglycemia 📈 Retatrutide delivered impressive glycemic control as monotherapy 🔗 diabetestrialfiles.substack.… #Diabetes #MedTwitter

📚New Critical Care Trial Files! 🩸Frozen platelets were not noninferior for surgical bleeding 🫁Post-op pneumonia markedly ↑ mortality after cardiac surgery 🫁Early extubation after thrombectomy offered no added benefit 🔗 criticalcaretrialfiles.subst… #CriticalCare #MedTwitter

📚Cardio Trial Files Throwback ❤️Dapa ↑ cardiometabolic outcomes after MI but not CV death or HF hospitalization 🫀Edoxaban offered no net benefit for device-detected AHREs 🧬Lepodisiran ↓Lp(a) by up to 97% with a single dose 🔗cardiotrialfiles.substack.co… #Cardiology #MedTwitter

📚New Trial Files! 🦠Cefazolin was noninferior to ASPs for MSSA with less AKI 💊Oral fosfomycin replaced IV β-lactams for selected complicated UTIs 🫁YEARS reduced CTPA use in cancer patients with suspected PE 🔗trialfiles.substack.com/p/tr… #MedTwitter #FOAMed

📚New Heme Onc Trial Files Throwback! 🧬Ibrutinib improved frontline outcomes and questioned the role of ASCT 💊Acalabrutinib+R-CHOP showed outstanding response rates 👥Acalabrutinib+BR prolonged PFS in older patients with MCL 🔗hemeonctrialfiles.substack.c… #HemeOnc #MedTwitter

📚Nephro Trial Files Throwback! 🩺Finerenone reduced CKD progression and CV events in T2DM 🩸STARRT-AKI found no benefit to accelerated dialysis initiation 💧High-dose hemodiafiltration reduced mortality vs conventional HD 🔗nephrotrialfiles.substack.co… #Nephrology #MedTwitter

📚New Critical Care Trial Files Throwback! 🫁ACURASYS suggested benefit with early paralysis ⚖️Routine neuromuscular blockade = no mortality benefit 🔄Early prone positioning dramatically improves survival in severe ARDS 🔗criticalcaretrialfiles.subst… #CriticalCare #MedTwitter