@InterProDB

InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites

 EBI, Cambridge, UK
ebi.ac.uk/interpro/
Joined September 2012
  • Tweets732
  • Following1.8K
  • Followers2.2K
257Media
🚀 InterPro 110.0 is live! ✨ Updated to NCBIFam 20.0 ✨ 854 new InterPro entries Explore the latest annotations and discover new protein insights. Explore it now: ebi.ac.uk/interpro/
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Here is the link to our latest blogpost going through all the updates included in InterPro 110.0 and the release of InterProScan 6 🥳ebi.ac.uk/about/news/updates…

InterPro 110.0 and InterProScan 6: a re-engineered pipeline and AI-ready access to the protein...

A rebuilt InterProScan, InterPro-N predictions for your own sequences, a new Matches API and an MCP server bring faster, self-service and AI-ready protein classification

ebi.ac.uk
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🚀 InterPro 108.0 is live! ✨ Updated to Pfam 38.1 and NCBIFam 18.0 ✨ 1,911 InterPro entries Explore the latest annotations and discover new protein insights. Explore it now: ebi.ac.uk/interpro/
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🚀InterPro 107.0 is live! ✨Updated to Pfam 38.0 ✨1,068 new InterPro entries Explore the latest annotations and discover new protein insights. Explore it now: interpro.ebi.ac.uk
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Quinoa thrives at 4,000m altitude where many crops struggle. Research shows Heat Shock Proteins (Hsp70) help protect plant cells from environmental stress. These molecular mechanisms in traditional crops may inform climate-resilient agriculture strategies. proteinswebteam.github.io/in…
InterPro page with a list of the quinoa sequences in UniProtKB that belong to the HSP70 family.

ALT InterPro page with a list of the quinoa sequences in UniProtKB that belong to the HSP70 family.

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Interested in studying Parkinson's disease? Have a look at our blog post below
InterPro@InterProDB31 Jan 2025
🧬 New blog post: Diving deep into the key proteins behind Parkinson's disease. From α-synuclein to LRRK2, we're unravelling the molecular mysteries that could hold the key to treatment breakthroughs. Read more: proteinswebteam.github.io/in… #Parkinsons #Neuroscience
Parkinson's disease molecular mechanisms

ALT Parkinson's disease molecular mechanisms

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InterPro retweeted
Ensembl@ensembl2 Sep 2025
📢 Happy to announce that Ensembl 115 and Ensembl Genomes 62 are out! This release features ~120000 new protein coding transcripts in human GRCh38, 2 new cattle, 7 new plants and 20 new metazoa! 🧬🐮 🫛🪲 Read more here ➡️ zurl.co/poyXM
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Feature Spotlight: Taxonomy Sunburst Discover the taxonomic breadth of your InterPro entry at a glance with our dynamic sunburst chart! 🕸️
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Click any segment to: ✨List matching proteins ✨Download FASTA files ✨Jump to the taxonomy entry for deeper insights
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Try it now on your favorite InterPro entry! ebi.ac.uk/interpro/entry/Int…
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InterProScan 6 (beta) is here 🎉 A Nextflow-powered, containerised overhaul for scalable, reproducible protein annotation—decoupled software/data, automated data handling, and smoother runs across HPC and cloud. Feedback welcome! github.com/ebi-pf-team/inter…
InterProScan 6 (beta) Nextflow - Containerised - Reproducible outputs Start with FASTA file InterProScan workflow: Annotate proteins (and nucleotides) with families, domains & sites Select analyses (e.g. Pfam, PANTHER, CDD, NCBIFAM...) Optional: GO and pathway annotations Output formats: JSON, TSV, XML, GFF3

ALT InterProScan 6 (beta) Nextflow - Containerised - Reproducible outputs Start with FASTA file InterProScan workflow: Annotate proteins (and nucleotides) with families, domains & sites Select analyses (e.g. Pfam, PANTHER, CDD, NCBIFAM...) Optional: GO and pathway annotations Output formats: JSON, TSV, XML, GFF3

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🧬 The InterPro/Pfam team will be presenting at #ISMB2025 next week in Liverpool! 🎤 Multiple talks & 📊 posters on protein analysis & classification
Poster A-098: Pfam database in 2025 – towards expanding protein families coverage Nicole Morveli Flores Session A: 21/07/2025 10:00 – 11:20 and 16:00 – 16:40 BST Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

ALT Poster A-098: Pfam database in 2025 – towards expanding protein families coverage Nicole Morveli Flores Session A: 21/07/2025 10:00 – 11:20 and 16:00 – 16:40 BST Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

InterProScan 6: a modern large-scale protein function annotation pipeline Matthias Blum 21/07/2025 14:20 Room 03A Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

ALT InterProScan 6: a modern large-scale protein function annotation pipeline Matthias Blum 21/07/2025 14:20 Room 03A Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

Poster A-205: Carbohydrate active enzymes in Pectobacteriaceae: coevolving enzyme sets and host adaptation Emma Hobbs Session A: 21/07/2025 10:00 – 11:20 and 16:00 – 16:40 BST Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

ALT Poster A-205: Carbohydrate active enzymes in Pectobacteriaceae: coevolving enzyme sets and host adaptation Emma Hobbs Session A: 21/07/2025 10:00 – 11:20 and 16:00 – 16:40 BST Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

Accelerating protein family classification in InterPro with AI innovations Matthias Blum 22/07/2025 16:40 Room 12 Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

ALT Accelerating protein family classification in InterPro with AI innovations Matthias Blum 22/07/2025 16:40 Room 12 Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

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🧬 The InterPro/Pfam team will be presenting at #ISMB_ECCB2025 next week in Liverpool! Join us July 20-24 at the world's largest #bioinformatics conference! #ProteinAnalysis #ComputationalBiology
The InterPro/Pfam team members attending ISMB/ECCB 2025: Alex Bateman, Emma Hobbs, Matthias Blum, Nicole Morvelli, Antonina Andreeva Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

ALT The InterPro/Pfam team members attending ISMB/ECCB 2025: Alex Bateman, Emma Hobbs, Matthias Blum, Nicole Morvelli, Antonina Andreeva Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

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🧬✨ Excited to present at @JOBIM2025 this week in Bordeaux! 🎤 Talk: Pfam: embracing AI/ML by @TyphainePl 📊 Poster #97: InterPro: Accelerating Protein Annotation with AI by @matthiasblum
JOBIM logo 9 to 11th July 2025 Bordeaux

ALT JOBIM logo 9 to 11th July 2025 Bordeaux

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Level up your protein prediction skills with the updated EMBL-EBI Training AlphaFold practical course. Now featuring #AlphaFold Server and AlphaFold 3. Start your training today: ebi.ac.uk/training/online/co… @GoogleDeepMind @emblebi #proteinbiology #bioinformatics
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Does taste depend on our genes? Discover how variations in taste receptors—from TAS2Rs that gate bitterness to olfactory genes that make cilantro taste soapy—and even pain receptors for spice shape what we love (and hate) on our plates. Read more: proteinswebteam.github.io/in…
Schematic diagram showing taste signal transmission between the tongue (with taste buds that contain taste cells harbouring GPCRs) and brain. Taste GPCRs are activated by specific food compounds, recruit specific G proteins that further induce intracellular calcium release. Adapted from [https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/28:_Biosignaling_-_Capstone_Volume_I/28.18:_Signal_Transduction_-_Taste_(Gustation)].

ALT Schematic diagram showing taste signal transmission between the tongue (with taste buds that contain taste cells harbouring GPCRs) and brain. Taste GPCRs are activated by specific food compounds, recruit specific G proteins that further induce intracellular calcium release. Adapted from [https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/28:_Biosignaling_-_Capstone_Volume_I/28.18:_Signal_Transduction_-_Taste_(Gustation)].

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🚀 HUGE NEWS: Pfam 37.4 is LIVE! 318 brand new protein families + 4 new clans! 🧬 Total collection now: 24,736 entries! 📈 Get exploring via InterPro website, API & Pfam FTP!
Pfam 37.4 318 new families 4 new clans

ALT Pfam 37.4 318 new families 4 new clans

Content Over 24,736 entries describing protein families, domains and repeats.

ALT Content Over 24,736 entries describing protein families, domains and repeats.

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🚀 InterPro 106.0 is now live! ✨ Updated to Pfam 37.4 ✨ 683 new entries added ✨ Enhanced protein classification coverage Explore the latest annotations and discover new protein insights. Explore it now: interpro.ebi.ac.uk/
InterPro 106.0 19th June 2025

ALT InterPro 106.0 19th June 2025

Databases updates: Pfam 37.4

ALT Databases updates: Pfam 37.4

New entries: 683 new entries with: 613 Pfam 78 NCBIfam 30 CDD 4 PANTHER ...

ALT New entries: 683 new entries with: 613 Pfam 78 NCBIfam 30 CDD 4 PANTHER ...

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