🔬Dynamics of immune responses to pathogens and tumors. 📍San Raffaele Scientific Institute & University, Milan @SanRaffaeleMI @MyUniSR
Milan, Lombardy
Joined March 2011
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Hot off the press in @SciImmunology: why COVID-19 hits older hosts harder.
shorturl.at/kedsb
Aged platelets release more serotonin → procoagulant platelets → fibrin in the lung → respiratory failure. 1/2
Iannacone Lab retweeted
Scientists with @DavideMarotta18 at @MyUniSR found that platelet-derived serotonin promotes blood clotting and lung dysfunction during #SARSCoV2 infection, helping explain greater disease severity with age. 🩸
🔬 bit.ly/4hdgEst
Tune into the discussion: bit.ly/3VE92Ik
Iannacone Lab retweeted
Delighted to share new work published in @ScienceMagazine entitled 'Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species,' led by @XanWesolowski in the lab science.org/eprint/YQNFAHKNF…
Blocking serotonin uptake or 5-HT2A protects, with no cost to viral control.
Kudos to postdoc @DavideMarotta18, who spearheaded this, and to @MarcoDegiov89 for co-supervising - a genuinely fun collaboration between our two labs at @SanRaffaeleMI @MyUniSR 2/2
Iannacone Lab retweeted
Online now! @EnriqueGab, @gsotoheredero et al identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated myelopoiesis. Blocking this axis improves healthspan in aged mice @MMittelbrunn nature.com/articles/s43587-0…
Iannacone Lab retweeted
The immune system does not behave in the same way in every tissue.
The first UniSR – @Tsinghua_Uni symposium explored new perspectives on cancer immunotherapy, neuroimmune interactions and immune memory.
👉Read more: blog.unisr.it/en/immunology-…
#UniSR #Immunology @iannaconelab
🔬 Recruiting a Physician Scientist PhD student (San Raffaele, Milan) via AIRC-Cariplo-SEMM-UniMi program. Project: reprogramming tumor endothelium to restore anti-tumor immunity in liver cancer. Keep 20% clinical work. Deadline Sept 16.
Apply: tinyurl.com/3vcp27dp
#AIRC
Fascinating work from the @IdoAmitLab! A must read
1/15 Can we engineer safer, more effective CAR T cells for MS? New in @CellCellPress: we identify pathogenic PD-1⁺ T cells and target them with inflammation-gated CAR T cells that reprogram neuroinflammation. @Rotem_Shalita @mayaby15 Chamutal Gur
cell.com/cell/fulltext/S0092…
Great science and fun at our lab's annual retreat, bringing together my team with Mirela Kuka, @MarcoDegiov89, and Donato Inverso's teams. Thanks to invited speakers @Lo_Zanzi and Stefano Sammicheli for inspiring lectures and great questions. Proud of what we've built together.
In vista della Giornata Mondiale dell'Epatite (28 luglio), abbiamo raccontato a UniSR le due strategie complementari su cui lavoriamo per la cura funzionale dell'epatite B cronica 🔗 blog.unisr.it/cura-funzional…
Proud of Dr. @ValentinaVenzin, a former PhD student in my lab, for winning the EFIS ACTERIA Doctoral Thesis Prize! Her work revealed how CD4+ T cells rescue dysfunctional CD8+ T cells in the liver during chronic HBV via IL-27. Congrats, Valentina! 🎉
efis.org/news/the-fondation-…
Iannacone Lab retweeted
Exciting news!👉LiveRNA, co-founded by @iannaconelab, has received the Paris-Saclay Cancer Cluster BOOST Grant to advance its next-generation #mRNA #immunotherapy platform and bring innovative cancer treatments closer to patients.
Pleased to have contributed to this new @ScienceMagazine paper on how lymphoid tissue chemokines limit CD8⁺ T cell priming duration to preserve T cell functionality. Congrats to @LukasAltenburg2 and Jens Stein! science.org/doi/10.1126/scie…
Iannacone Lab retweeted
Review @NatRevImmunol @Kubes_Lab @FGinhoux @iannaconelab
Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers
nature.com/articles/s41577-0…
Great fun to write this review on Kupffer cells with @FGinhoux and @Kubes_Lab, covering origin, diversity and roles in immunity and metabolism, now out @NatRevImmunol. Huge credit to Bruna Araujo David, @frarro1 and Camille Blériot for driving this work. rdcu.be/fckoZ
Iannacone Lab retweeted
Abortive infection: T cells as early, antibody-independent defenders dlvr.it/TRrTjj
Neutralizing antibodies are not the whole story. In @NatRevImmunol, we highlight an alternative mode of protection: T cells can eliminate infection at its earliest stage, before it becomes detectable. We term this “abortive infection”
rdcu.be/fbq8p
Thread 1/4
Implications:
• T cells can act at inception, not just during clearance
• Standard readouts (serology/PCR) miss these events
• True exposure and immunity are likely underestimated
→ We need to measure what T cells actually do
This calls for a shift in vaccine design:
• target early, conserved viral proteins
• build tissue-resident immunity
• combine antibodies and T cells
Great collaboration with Leo Swadling, @ValeFuma91 and @maini_lab