@INCEPTdk

INCEPT: The Intensive Care Platform Trial research programme. Profile no longer active, updates on website: https://xitter.cf/t.co/hesjeYJUCu

 Copenhagen, Denmark
incept.dk
Joined April 2021
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  • Followers130
The Intensive Care Platform Trial (INCEPT) research programme aims to prepare, initiate and run an adaptive platform trial assessing commonly used interventions in acutely ill intensive care unit (ICU) patients. Follow this account and incept.dk for updates!

Home (bricks)

The Intensive Care Platform Trial (INCEPT) is an international adaptive platform trial aimed at improving care for adults acutely admitted to the intensive care unit. {post_date} {post_title} Latest...

incept.dk
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Replying to @INCEPTdk
We are so thrilled to receive this award on behalf of all the research panels involved. For the curious reader our core outcome set is now available as a preprint: medrxiv.org/cgi/content/shor…
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adaptr #rstats package for simulating complex adaptive trials with adaptive stopping, arm dropping, and randomisation updated to v.1.40 - link and details below. @INCEPTdk
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A step into the future of clinical trials, shaped by the critical care community. @PRACPLATFORM @REMAP6 @EdinUni_TRAITS @INCEPTdk @panther_trial @remap_cap @AndersPerner @msh_manu @ecgoligher @efan75 @dfmcauley @srinmurthy99 🔗 bit.ly/3UYrMjF
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'The Rise of Adaptive Platform Trials in Critical Care' New @ATSBlueEditor led by @ecgoligher @efan75 @PRACPLATFORM w/* @REMAP6 @EdinUni_TRAITS @INCEPTdk @panther_trial @AndersPerner @msh_manu @srinmurthy99 @dfmcauley @SarinaKS 🔓: doi.org/10.1164/rccm.202401-… *tagged my best
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Interested in conditional average treatment effects (ie, CATE) to assess HTE in a Bayesian causal framework? Chk out (esp our supp & git page): nature.com/articles/s41598-0… Co-led by @BryanBlette & @andersgranholm, w/ @msh_manu @AndersPerner @FanLi90 & some of the @INCEPTdk team.
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New version of our 'adaptr' R package on CRAN including important new functionality (trial calibration) and other improvements - see inceptdk.github.io/adaptr/ and thread below if you're interested in simulation of complex adaptive trial designs. 1/..
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Are days alive without life support/out of hospital (DAWOLS/DAOOH) associated with longer-term health-related quality of life (HRQoL)? We aimed to find out - new article online (OA), doi.org/10.1111/aas.14231, conducted as part of the @INCEPTdk programme. 1/..

Association between days alive without life support/out of hospital and health‐related quality of...

Background Trials in critically ill patients increasingly focus on days alive without life support (DAWOLS) or days alive out of hospital (DAOOH) and health-related quality of life (HRQoL). DAWOLS...

onlinelibrary.wiley.com
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Version 1.2.0 of the 'adaptr' R package for simulating adaptive clinical trials with adaptive stopping, arm dropping and randomisation on CRAN; details at: inceptdk.github.io/adaptr/ w/ @benskov @LangeTheis Aksel KG Jensen @INCEPTdk 1/..
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Now online in @JClinEpi (OA): jclinepi.com/article/S0895-4… In this manuscript we provide an overview of the key methodological considerations for (multi-arm, multi-stage) clinical trials using adaptive stopping, arm dropping, and randomisation with a worked example. Details below 1/

An overview of methodological considerations regarding adaptive stopping, arm dropping, and...

Adaptive features may increase flexibility and efficiency of clinical trials, and improve participants’ chances of being allocated to better interventions. Our objective is to provide thorough...

jclinepi.com
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#causalinference from #ICU #secondarydata could inform and guide critical care #RCTs. But is it used? We're setting out to find out: doi.org/10.1111/aas.14142 @INCEPTdk

Causal inference for planning randomised critical care trials: Protocol for a scoping review

Background Randomised clinical trials in critical care are prone to inconclusiveness owing, in part, to undue optimism about effect sizes and suboptimal accounting for heterogeneous treatment...

onlinelibrary.wiley.com
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New paper in @CritCareMed: to inform selection and handling of patient-important outcomes other than mortality in @INCEPTdk, we conducted a scoping review summarising selection, definition, and handling of these outcomes in contemporary ICU trials (1/..) doi.org/10.1097/ccm.00000000…
Abstract

ALT Abstract

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Minor update to the 'adaptr' R package for adaptive trial simulation now available on CRAN (cran.r-project.org/web/packa…). Details on the package available below and on inceptdk.github.io/adaptr/. @INCEPTdk @benskov @LangeTheis

adaptr: Adaptive Trial Simulator

Package that simulates adaptive (multi-arm, multi-stage) clinical trials using adaptive stopping, adaptive arm dropping, and/or adaptive randomisation. Developed as part of the INCEPT (Intensive Care...

cran.r-project.org
Anders Granholm@andersgranholm28 Apr 2022
We have a paper on our 'adaptr' R-package for adaptive trial simulation and comparison (developed as part of the @INCEPTdk project) published in @JOSS_TheOJ joss.theoj.org/papers/10.211…. The package is documented on a stand-alone website at inceptdk.github.io/adaptr/. (1/6)
adaptr: an R package for simulating and comparing adaptive clinical trials paper in the Journal of Open Source Software

ALT adaptr: an R package for simulating and comparing adaptive clinical trials paper in the Journal of Open Source Software

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This week, the INCEPT programme received the ‘Innovation of the year’-award in the first Danish awards ceremony for clinical trials. We are proud and highly motivated to continue our work on establishing the INCEPT platform trial! Coverage (in Danish): dagensmedicin.dk/syv-glade-v…
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We have a paper on our 'adaptr' R-package for adaptive trial simulation and comparison (developed as part of the @INCEPTdk project) published in @JOSS_TheOJ joss.theoj.org/papers/10.211…. The package is documented on a stand-alone website at inceptdk.github.io/adaptr/. (1/6)
adaptr: an R package for simulating and comparing adaptive clinical trials paper in the Journal of Open Source Software

ALT adaptr: an R package for simulating and comparing adaptive clinical trials paper in the Journal of Open Source Software

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Just published in JOSS: '`adaptr`: an R package for simulating and comparing adaptive clinical trials' doi.org/10.21105/joss.04284
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Now also available on CRAN: cran.r-project.org/web/packa…

adaptr: Adaptive Trial Simulator

Package that simulates adaptive (multi-arm, multi-stage) clinical trials using adaptive stopping, adaptive arm dropping, and/or adaptive randomisation. Developed as part of the INCEPT (Intensive Care...

cran.r-project.org
Anders Granholm@andersgranholm14 Mar 2022
adaptr: Adaptive Trial Simulator - new #rstats package for simulating adaptive trials: inceptdk.github.io/adaptr/ Simulates/compares trial designs using adaptive stopping, arm dropping and randomisation. Developed as part of the @INCEPTdk project. Details below: (1/6)
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adaptr: Adaptive Trial Simulator - new #rstats package for simulating adaptive trials: inceptdk.github.io/adaptr/ Simulates/compares trial designs using adaptive stopping, arm dropping and randomisation. Developed as part of the @INCEPTdk project. Details below: (1/6)
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Development of a core outcome set for general intensive care unit patients—A protocol #StrongWork onlinelibrary.wiley.com/doi/… – at Copenhagen, Denmark

Development of a core outcome set for general intensive care unit patients—A protocol

Introduction Different outcomes are reported in randomised clinical trials (RCTs) in intensive care unit (ICU) patients, and no core outcome set (COS) is available for ICU patients in general....

onlinelibrary.wiley.com
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