Respiratory 🫁 doctor. Specialist interest in asthma
London, England
Joined January 2013
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Tweetorial for UK docs using @CernerUK PowerChart (not sure if this format will be useful but here goes)
First a question: how would you rate yourself as a PowerChart user?
19%Basic
40%Average
36%Better than average
5%Expert
171 votes • Final results Hugo Farne 🫁 retweeted
Great work from @alferes_de and @lifearc1 - a molecular test for Pseudomonas which is more sensitive than culture, quantitative and changes over time with treatment/clinical status.
We are working now on using this as an endpoint in clinical trials. More to come!
A novel bacterial quantification assay (BQA) targeting ribosomal RNA for the detection of viable P. aeruginosa from clinical samples in bronchiectasis has been developed. The BQA shows promise as an early detection diagnostic and treatment monitoring tool. bit.ly/4rf7rnr
Hugo Farne 🫁 retweeted
Further evidence of the challenges in targeting the mighty neutrophil.
Our trial of Myeloperoxidase (MPO) inhibition in COPD found no efficacy, and increased pneumonia
Just published in @ERSpublications
publications.ersnet.org/cont…
Hugo Farne 🫁 retweeted
New research confirms what we've suspected for a long time - the "test dose" of hypertonic saline in clinic does nothing except test the variability of spirometry as a measure
Most people who failed the test passed a repeat. Most people who couldn't tolerate HTS long term passed the test first time
thorax.bmj.com/content/early…
Hugo Farne 🫁 retweeted
I’m not a BMA member, but this statement is one I support: Reducing funding for clinical academics when numbers are already in decline fails to recognise their contribution to the health & wealth of the UK.
The financial saving is minimal but I fear the costs will be substantial
Responding to @officestudents guidance from the Secretary of State for Education setting out funding for 2026-27 for universities that imposes cuts to funding for medical academics: bma.org.uk/bma-media-centre/…
Hugo Farne 🫁 retweeted
Responding to @officestudents guidance from the Secretary of State for Education setting out funding for 2026-27 for universities that imposes cuts to funding for medical academics: bma.org.uk/bma-media-centre/…
Hugo Farne 🫁 retweeted
This study validates a previously reported bronchial signature of bronchiectasis in nasal epithelium. Changes in gene expression and cell-type composition associated with radiological bronchiectasis are similar across both bronchial and nasal epithelia. bit.ly/4qgq7SO
Hugo Farne 🫁 retweeted
European Respiratory Journal: TSC2 mutations are the main cause of sporadic LAM in nearly all patients bit.ly/4rZoqtJ
Hugo Farne 🫁 retweeted
Inhaled anti-TSLP for persistent asthma -Phase 1 study
linkinghub.elsevier.com/retr…
AZD8630 well tolerated with low incidence of ADA
Suppression of FeNO indicating effects on airway epithelial cells and downstream IL13 signalling
Hugo Farne 🫁 retweeted
Excited to share our ‘Evolutionary characterization of #LungCancer metastasis’ in #TRACERx & #PEACE, published today in @Nature: a decade spanning effort led by the Jamal-Hanjani lab, @SwantonLab, @NickyMcGranahan & @ZaccaSimo at @uclcancer & @TheCrick. Link below
Hugo Farne 🫁 retweeted
A study 10 years in the making, just published in @LancetRespirMed
How do DPP1 inhibitors really work in bronchiectasis?
We show a novel mechanism for treatment efficacy, by inhibiting Azurocidin-1, a ciliotoxin, DPP1i can enhance mucociliary clearance.
thelancet.com/journals/lanre…
Hugo Farne 🫁 retweeted
ECCMID 2026
No induction of resistance over 6 months with monoclonal antibody therapy against pseudomonas in bronchiectasis
Encouraging beneficial changes to the microbiome too
Encouraging early results presented by @beccahull_
Hugo Farne 🫁 retweeted
Inhaled immunoglobulin as a novel treatment for bronchiectasis: results from a phase 1 trial
Inhaled immunoglobulin G was associated with low rates of adverse events and reduced airway bacterial burden. Encouraging results! Online now at @ATSBlueEditor
academic.oup.com/ajrccm/adva…
Hugo Farne 🫁 retweeted
People often ask how breakthroughs occur in cancer biology-often the story is more complex - the survival plot for myeloma outcomes is extraordinary - improvements come about in incremental steps - in my lifetime treatment of Myeloma has almost transformed into a curable disease
Hugo Farne 🫁 retweeted
No cigar for Rilzabrutinib (BTK inhibitor) in mod-sev asthma (Ph 2)
Futility on primary EP of loss of asthma control upon withdawal of ICS/LABA
thelancet.com/journals/lanre…
It makes no sense to me to close roads and dig them up just before a 4 day bank holiday with the disruption inevitably being extended by 4 more days?
@MayorofLondon can you make it prohibitively expensive to do this?
@CadentGasLtd @UKPowerNetworks @thameswater
@DHSCgovuk @wesstreeting
Resident doctor strikes have highlighted all sorts of issues.
Not least the inefficient process to sign up to the bank to locum. Why do occupational health checks have to be in person? And why can’t in person ID checks be at the nearest hospital HR?
1/
This data from the charity @asthmalunguk was kindly highlighted to the public by @tobithomas_ and @guardian.
Asthma and COPD remain common and major causes of ill health and death both in the UK and globally, yet both are underfunded (especially COPD).
“A stark and avoidable injustice in respiratory health” ⚖️
This, in the words of @HugoResp, is the situation laid bare by a recent analysis of NHS admissions data by @asthmalunguk 🫁
Dr Farne was interviewed as part of @guardian coverage of the study: theguardian.com/society/2025…
Hugo Farne 🫁 retweeted
“A stark and avoidable injustice in respiratory health” ⚖️
This, in the words of @HugoResp, is the situation laid bare by a recent analysis of NHS admissions data by @asthmalunguk 🫁
Dr Farne was interviewed as part of @guardian coverage of the study: theguardian.com/society/2025…