Structural biologist @CNRS. Ion channels & membrane proteins.

Joined January 2015
Hugues Nury retweeted
Happy Sunday to all! This morning, we are excited to share Chase’s work developing a simple, scalable method to assemble 100s-1000s of custom genes from oligo pools using standard lab tools! (Small 🧵 below)
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Happy to share our paper in @NatureSMB, led by @uriellopezs and Lachlan Munro. We are studying how the antidepressant vortioxetine acts on serotonin 5-HT3 receptors in rodents and humans. rdcu.be/dGv49
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Very excited and proud to see the first manuscript of the Wild Team on bioRxiv. If you have ever wondered how the long heparan sulfate polysaccharide chains on the human cell surface are generated, check out our cryo-EM structure of the EXT1-EXT2 complex: biorxiv.org/content/10.1101/…
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Ottawa is beautiful in May - great time for a ligand-gated ion channel meeting: event.fourwaves.com/jointbsc…
Ion channel friends … wonderful meeting in beautiful Ottawa coming up in just a bit more than three weeks! #biophysics
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🦠🥼🧪 JOB ALERT 🇫🇷🔬🇪🇺 Join us for an exciting 2-year post doc position ! “Structure function study of a tripartite efflux pump from the ABC superfamily, in its lipid environment”, spread the word ! umr7099.ibpc.fr/apply-for-fe… bit.ly/3o2mYIB euraxess.ec.europa.eu/jobs/7…
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- ET MOI JE VOUS DIS QU'ON N'A PAS ASSEZ DE RECUL !!!
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The probability of any receptor being a drug target for COVID, over time, tends towards 1. It took 1.5 years but finally my beloved serotonin 5-HT3 receptor is added to the list... 😁
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Structural biology PhD position open in our lab, to understand how ligand-gated ion channels operate. Please RT.
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I am happy to announce that we have funding for a new postdoc position in my lab. If interested, please see ad Postdoctoral Fellow in Neuroscience lab job with Icahn School of Medicine at Mount Sinai New York City, New York (US) neurojobs.sfn.org/job/27911/… #jobs
Slice in an ongoing #CryoEM classification. The outer circle is a lipid nanodisc density. Seems like the protein inside is happy to be there.
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« J’ai perdu mon bébé ». L'ONG @openarms_fund - avec le seul bateau de sauvetage encore en activité en Méditerranée- vient de porter secours à 263 personnes qui tenaient de gagner l'Europe. 5 adultes et le bébé de 6 mois sont morts. Insoutenable scène
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I am happy to see our paper in Press! This work provides evidence of a cross-talk between SLC20A2 and XPR1 in the regulation of cellular phosphate homeostasis. Alteration of this interplay likely contributes to Primary Familial Brain Calcification. jbc.org/cgi/content/long/RA1…
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STATEMENT BY THE @ERC_research SCIENTIFIC COUNCIL erc.europa.eu/news/resignati…
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First preprint (and tweet)! Binding of palonosetron + other antiemetics to the serotonin 5-HT3 receptor. CryoEM and simulations. biorxiv.org/content/10.1101/… (Please note: same topic, last summer, similarly cool granisetron-bound structure from @Chakrapani_lab @sandipbasak21)
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Coordinates to be released with the next PDB update, please DM for links in the meantime
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