@HornsteinLab

HornsteinLab @WeizmannScience | Mechanisms of Neurodegeneration | #ALS | #noncodingRNA | #phaseseparation | #neurogenetics | #biomarkers | computational biomed

 Weizmann Institute of Science
weizmann.ac.il/molgen/members/hornstein/eran_group/main.html
Joined September 2018
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Introducing organellomics - a systems-level view of human cell architecture with 24 organelles. AI-driven ๐—ก๐—ข๐—ฉ๐—” (๐—กeuronal ๐—ขrganellomics ๐—ฉision ๐—”tlas) encodes organelle patterns in 1.5M+ neuron images, enabling holistic insights in cellular biology biorxiv.org/content/10.1101/โ€ฆ
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Hornstein Lab retweeted
Alzforum@alzforum24 Sep 2025
TDP-43 may play a role in neurodegenerative disorders such as #alzheimersdisease and #parkinsonsdisease, even in the absence of detectable aggregates. @UKDRI @Cambridge_Uni @WeizmannScience @EmoryMedicine ow.ly/thRc50X1sgM
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Wearable robot gives ALS patients a hand buff.ly/BTxGLnp #ALS #AmyotrophicLateralSclerosis #ALSDisease #ALSTreatment #ALSResearch
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Hornstein Lab retweeted
medRxiv@medrxivpreprint12 May 2025
IsomiR Utility in ALS Prognostication medrxiv.org/cgi/content/shorโ€ฆ #medRxiv
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Hornstein Lab retweeted
Leeat Keren@leeat_keren25 Mar 2025
Super excited to finally see this published! Our new method to use combinatorial staining and deep learning to push the multiplexing boundaries of spatial proteomics!
Nature Biotechnology
@NatureBiotech25 Mar 2025
High-dimensional imaging using combinatorial channel multiplexing and deep learning go.nature.com/4hGPfO0
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Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's a dedicated organization to oversee the servers] openrxiv.org 1/n
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Excited to share our preprint: "๐Ž๐ซ๐ ๐š๐ง๐ž๐ฅ๐ฅ๐จ๐ฆ๐ข๐œ๐ฌ: ๐€๐ˆ-๐๐ซ๐ข๐ฏ๐ž๐ง ๐๐ž๐ž๐ฉ ๐จ๐ซ๐ ๐š๐ง๐ž๐ฅ๐ฅ๐š๐ซ ๐ฉ๐ก๐ž๐ง๐จ๐ญ๐ฒ๐ฉ๐ข๐ง๐  ๐ซ๐ž๐ฏ๐ž๐š๐ฅ๐ฌ ๐ง๐จ๐ฏ๐ž๐ฅ ๐€๐‹๐’ ๐ฆ๐ž๐œ๐ก๐š๐ง๐ข๐ฌ๐ฆ๐ฌ ๐ข๐ง ๐ก๐ฎ๐ฆ๐š๐ง ๐ง๐ž๐ฎ๐ซ๐จ๐ง๐ฌ"
Nancy Yacovzada@NancyYaco10 Mar 2025
๐Ÿš€๐•๐ข๐ฌ๐ข๐จ๐ง-๐ญ๐ซ๐š๐ง๐ฌ๐Ÿ๐จ๐ซ๐ฆ๐ฌ-๐›๐š๐ฌ๐ž๐ ๐จ๐ซ๐ ๐š๐ง๐ž๐ฅ๐ฅ๐š๐ซ ๐ฉ๐ก๐ž๐ง๐จ๐ญ๐ฒ๐ฉ๐ข๐ง๐  ๐ฎ๐ง๐ฏ๐ž๐ข๐ฅ๐ฌ ๐ก๐ข๐๐๐ž๐ง ๐€๐‹๐’ ๐ฆ๐ž๐œ๐ก๐š๐ง๐ข๐ฌ๐ฆ๐ฌ! ๐Ÿงต Thread on ๐˜•๐˜–๐˜๐˜ˆ (๐˜•๐˜ฆ๐˜ถ๐˜ณ๐˜ฐ๐˜ฏ๐˜ข๐˜ญ ๐˜–๐˜ณ๐˜จ๐˜ข๐˜ฏ๐˜ฆ๐˜ญ๐˜ญ๐˜ฐ๐˜ฎ๐˜ช๐˜ค๐˜ด ๐˜๐˜ช๐˜ด๐˜ช๐˜ฐ๐˜ฏ ๐˜ˆ๐˜ต๐˜ญ๐˜ข๐˜ด)๐ŸŽ—๏ธ our deep-learning model trained with ~3M images of human-derived neurons, and newly discovered insights into ALS disease. We used AI to map cellular dysfunction at un unprecedented resolution, comprehensively studying all sub-cellular organelles. Preprint: "๐Ž๐ซ๐ ๐š๐ง๐ž๐ฅ๐ฅ๐จ๐ฆ๐ข๐œ๐ฌ: ๐€๐ˆ-๐๐ซ๐ข๐ฏ๐ž๐ง ๐๐ž๐ž๐ฉ ๐จ๐ซ๐ ๐š๐ง๐ž๐ฅ๐ฅ๐š๐ซ ๐ฉ๐ก๐ž๐ง๐จ๐ญ๐ฒ๐ฉ๐ข๐ง๐  ๐ซ๐ž๐ฏ๐ž๐š๐ฅ๐ฌ ๐ง๐จ๐ฏ๐ž๐ฅ ๐€๐‹๐’ ๐ฆ๐ž๐œ๐ก๐š๐ง๐ข๐ฌ๐ฆ๐ฌ ๐ข๐ง ๐ก๐ฎ๐ฆ๐š๐ง ๐ง๐ž๐ฎ๐ซ๐จ๐ง๐ฌ" biorxiv.org/content/10.1101/โ€ฆ Check out our code and data: github.com/Sagykri/NOVA 1/n

Organellomics: AI-driven deep organellar phenotyping reveals novel ALS mechanisms in human neurons

Systematic assessment of organelle architectures, termed the organellome, offers valuable insights into cellular states and pathomechanisms, but remains largely uncharted. Here, we present a pipeline...

biorxiv.org
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Delighted to share new work from our lab: MultiPerturb-seq ๐ŸŽ›๏ธโŒ๐Ÿ“ฅ๐Ÿ“ค Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.
Nature Biotechnology
@NatureBiotech21 Nov 2024
Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling go.nature.com/4hXER5O
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The pure joy in Gaza as Iranian missiles cover the sky above Tel Aviv.
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Hornstein Lab retweeted
Alzforum@alzforum9 Aug 2024
At AAIC 2024, phospho-tau assays look ready for primary and secondary care. @lunduniversity @wustl @BannerAlzheimer ow.ly/QPzg50SV3Tp
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Hornstein Lab retweeted
medRxiv@medrxivpreprint1 Aug 2024
A phase Ib/IIa study of Enoxacin in patients with ALS medrxiv.org/cgi/content/shorโ€ฆ #medRxiv
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Hornstein Lab retweeted
Rahul Satija@satijalab25 Jun 2024
Interested in 3' UTR changes in scRNA-seq? Check out our: * CPA-Perturb-seq paper * UCSC Perturb-seq tracks (see who regulates your favorite 3โ€™ UTR!) * Seurat extension for polyA site analysis (PASTA) * Deep neural perturbation network (APARENT-Perturb) cell.com/cell/fulltext/S0092โ€ฆ

Multiplexed single-cell characterization of alternative polyadenylation regulators

CRISPR perturbation screens of 42 cleavage and polyadenylation regulators followed by 3โ€ฒ scRNA-seq (CPA-Perturb-seq) identifies modules of co-regulated polyA sites, their connection with distinct...

cell.com
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Birth of a neuron. Stem cell transforming into a brain cell: #neuroscience
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Human brain anatomy: #neuroscience
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Hornstein Lab retweeted
Nancy Yacovzada@NancyYaco18 Mar 2024
My team is working with a substantial arsenal of ML algorithms, analyzing diverse human molecular data. The most intriguing work imaginable. We do science and study human brain diseases, but like a small startup. Come join us!
Hornstein Lab@HornsteinLab18 Mar 2024
We're hiring! Biomedical Data Science Researcher to develop ML/AI tools and investigate molecular mechanisms underlying neurodegeneration. Position details and requirements: machinelearning.co.il/job/biโ€ฆ CV to [email protected] / [email protected] #jobopportunity
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We're hiring! Biomedical Data Science Researcher to develop ML/AI tools and investigate molecular mechanisms underlying neurodegeneration. Position details and requirements: machinelearning.co.il/job/biโ€ฆ CV to [email protected] / [email protected] #jobopportunity
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Two neurons having a conversation, surrounded by some busy microglia doing their job: maintaining neuronal networks and helping with injury, repair, and pruning! The brain is beautiful! ๐Ÿง ๐Ÿ”ฌ#neuroscience #Microscopy
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A confocal microscopy image of Your Majesty, the neuron, the king of the brain jungle ๐Ÿง ๐Ÿ”ฌ! This one is the classical pyramidal cell, the most common neuronal type in the mammalian cerebral cortex. In blue, staining for PSD95, a major protein in excitatory synapses that helps concentrate and organize neurotransmitter receptors in the synaptic cleft. Each little dark blue puncta shows an excitatory synapse happening between two neurons! Reduction or dysfunction in the PSD95 expression is related to impaired learning and working memory and is observed in diseases such as Alzheimer's and Parkinson's. Staining: ๐ŸŸ SMI32๐Ÿ”ตPSD95 #SynapticSunday @zeiss_micro
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Hornstein Lab retweeted
Nancy Yacovzada@NancyYaco1 Feb 2024
Our preprint of ๐‘ต๐‘ถ๐‘ฝ๐‘จ is out! A deep representation learning of 24 organelles in 1.5M ๐Ÿ”ฌ images of human iPSC-dervied cortical neurons. We tested stress, #ALS genetic perturbations, and more. What a fascinating road it was with this one.. ๐ŸŽข๐Ÿง ๐Ÿงช๐Ÿงซ
Hornstein Lab@HornsteinLab1 Feb 2024
Introducing organellomics - a systems-level view of human cell architecture with 24 organelles. AI-driven ๐—ก๐—ข๐—ฉ๐—” (๐—กeuronal ๐—ขrganellomics ๐—ฉision ๐—”tlas) encodes organelle patterns in 1.5M+ neuron images, enabling holistic insights in cellular biology biorxiv.org/content/10.1101/โ€ฆ
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A new bioRxive from our lab showing a new concept: #Organellomics in #Neurons that distinguishes between cell states and conditions. A huge imaging data set of neurons and an edvanced computational work come together! It was my pleasure to be part of this fantastic work!
Hornstein Lab@HornsteinLab1 Feb 2024
Introducing organellomics - a systems-level view of human cell architecture with 24 organelles. AI-driven ๐—ก๐—ข๐—ฉ๐—” (๐—กeuronal ๐—ขrganellomics ๐—ฉision ๐—”tlas) encodes organelle patterns in 1.5M+ neuron images, enabling holistic insights in cellular biology biorxiv.org/content/10.1101/โ€ฆ
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Hornstein Lab retweeted
Lena Molitor@MolitorLena1 Feb 2024
Check out our latest preprint about AI-driven ๐Ÿค– deep organellar phenotyping of human ๐Ÿง  neurons. biorxiv.org/content/10.1101/โ€ฆ

Organellomics: AI-driven deep organellar phenotyping of human neurons

Systematic assessment of organelle architectures in cells, known as the organellome, could provide valuable insights into cellular states and disease pathologies but remains largely uncharted. Here,...

biorxiv.org
Hornstein Lab@HornsteinLab1 Feb 2024
Introducing organellomics - a systems-level view of human cell architecture with 24 organelles. AI-driven ๐—ก๐—ข๐—ฉ๐—” (๐—กeuronal ๐—ขrganellomics ๐—ฉision ๐—”tlas) encodes organelle patterns in 1.5M+ neuron images, enabling holistic insights in cellular biology biorxiv.org/content/10.1101/โ€ฆ
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