باحثة طبية مكرسة تعشق الفكاهة والتاريخ.

Riyadh
Joined June 2022
Huda Saleh retweeted
More guidance on WHAT immunosuppressant should be your nr. 1️⃣ choice in autoimmune hepatitis! 👉🏻 Azathioprine versus mycophenolate mofetil in treatment-naive autoimmune hepatitis: 3 year follow up of the CAMARO trial sciencedirect.com/science/ar…
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Huda Saleh retweeted
Ken is both wrong and right at the same time. AI is a bubble in terms of current methods … but far from a bubble in terms of how it can truly be improved and scaled. youtu.be/QWzQo74cA7U?is=9ZAC…
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Exercise as anticancer medicine? Evidence, mechanisms and implementation in oncology cancertreatmentreviews.com/a…
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Huda Saleh retweeted
Very hot topic in scientific publishing! Presentation from our editorial board! @UEGJournal @my_ueg
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Omnii-1 is a huge milestone for @RadicalNumerics. Building it required advancing architectures, pre-training, post-training and inference to make new biological applications possible. Pre-training meant tokenizing and blending continuous and discrete biological modalities. Post-training adapted that foundation to different applications. At inference, we’re exploring algorithms for reasoning across biological modalities and allocating test-time compute across selective generation and conditioning steps. Making these models train and run at scale meant pushing the underlying numerics and systems alongside the modeling. The frontier of biological AI runs all the way down the stack. We have a cracked team. Really proud of what we’ve built together.
Introducing Omnii-1, our most powerful genome language model, and a major step toward general biological intelligence In a world first, Omnii-1 designed the first AI-generated bacteriophages to be administered to a human patient with an antibiotic-resistant infection under compassionate use
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Huda Saleh retweeted
PGS may help predict cardiometabolic disorder & #CVD risk in women w/ breast cancer, but current performance is limited. These findings highlight the need for de novo PGS & more ancestrally diverse populations jacc.org/doi/10.1016/j.jacca… #JACCCardioOnc #BreastCancerAwareness #BCsm
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Huda Saleh retweeted
Seventy-two participants were recruited. Adherence to the 10-day protocol was 100%. Constipation Assessment Scale scores decreased by 2.28 points, while quality-of-life scores improved by 17 points. Reduced laxative reliance was observed without changes in psychotropic regimens
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Huda Saleh retweeted
[Online (Teams) & in-person (Oxford, UK)] Conference: Latest ME Research from Prof Karl Morten and colleagues eventbrite.co.uk/e/latest-me… I was asked to highlight this today which I'm happy to do #MEcfs #PwME @OxMEDiscovery
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Huda Saleh retweeted
Lux family co @benchling at nexus of AI x SCIENCE
Just announced at Benchtalk: Science Foundries. Foundries bring together specialized agents and models to run entire scientific processes, whether it’s protein production, assay development, or lead optimization. A team of agents handles tasks and coordinates handoffs, while scientists still make the important decisions. More from Benchling’s @nlarusstone: benchling.com/blog/introduci…
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Huda Saleh retweeted
🫀 CardioNugget™: WPW Risk Stratification: Asymptomatic WPW pattern on ECG—what’s next? ⚡️ ➡️ Exercise stress testing can non-invasively risk-stratify the accessory pathway. 🟢 Abrupt + complete loss of the delta wave with exercise = LOW-risk pathway → pathway cannot conduct rapidly at higher HRs 🔴 Persistent pre-excitation (or only gradual loss) = HIGHER-risk pathway → capable of rapid conduction → ↑ risk of malignant arrhythmias/VF #CardioNugget #Cardiology #EP #WPW #MedEd
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T cells didn't need to be replaced with younger cells. Changing their physical environment to a more viscous medium was enough to restore youthful behaviour. Older T cells could still migrate before altering the niche but had difficulty changing shape and sensing biological signals. It proves a cell has little intrinsic value without environmental pressure to behave a certain way. nature.com/articles/s41467-0…
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Eating fruit before the rest of a meal can help reduce the blood glucose peak. “...pre-meal consumption of three fruits (orange, apple and pear) effectively curbed post-meal glycemia even in the case of a 30% extra carbohydrate load.” PMID: 34371978 “replacing part of a meal with kiwifruit may help with insulin efficiency without detriment to subsequent energy intake.” PMID: 30126094 “Compared with rice control, apple preload of 15 g available carbohydrates remarkably lowered the acute postprandial GR without negative effect on satiety. The sugar component may partly contribute to the glycemic suppressing effect of the apple preload.” PMID: 31810219 “The incremental area under the curve (iAUC) of insulin tended to decrease in the apple-first group. In the impaired glucose tolerance subjects, the Cmax of Δblood glucose was 75 in the apple-first group compared to 90 in the rice-first group, which was a significant difference... Eating an apple before a meal may be a simple and effective strategy for managing the glycaemic response in individuals with impaired glucose tolerance.” PMID: 35742001 “The study results showed significant reduction in postprandial glucose when strawberry was consumed before the meal compared to having the strawberry drink with the meal. Compared to the reference group, consuming strawberries before and after the meal attenuated postprandial glucose without additional insulin, suggesting improved insulin sensitivity... This study provides data suggesting that strawberries have a role in glycemic control and attenuating the pro-inflammatory effect of a modern diet. There may be particular advantages when strawberries are consumed before a meal.” PMID: 27761543 xitter.cf/lowmegatron/status/211…
You don’t need to go low-carb to fix insulin resistance. My new Substack article, with almost 300 citations, lays out the causes and the solutions. lowmegatron.substack.com/p/b…
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Huda Saleh retweeted
•Micro- and nanoplastics are emerging health hazards. •MNPs can induce oxidative stress and gastric inflammation. •Plastic particles alter key gastric carcinogenesis pathways. •Interactions with Helicobacter pylori worsen gastric damage. sciencedirect.com/science/ar…
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Saudi Medical Journal’s Artificial Intelligence, Issue 11 Is out! Read here ⬇️ smj.researchcommons.org/jour…
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Unfortunately, converting a lab from doing BSL-2 research to BSL-3/4 research is not difficult. The infrastructure changes are mostly to protect researchers, like negative air pressure and PPE. Execution of bioweapons development is difficult. While it is relatively easy to synthesize or mail-order a pathogen, there are other aspects of development which are hard, like figuring out how to grow and maintain it in culture. All aspects of this chain of development have gotten more accessible over time.
IFP's @OliviaHelenS reveals why repurposing a cancer research wet lab for dangerous pathogen research may be easier than most people think, and surprisingly easy to hide: "It's not as hard as I think a lot of people think it is. And it's more importantly very easy to hide." "There are aspects of building a bioweapon that are difficult. Growing and maintaining it is more difficult, but the actual lab infrastructure is not particularly different." "One of the reasons I'm excited about cloud labs and automation is I think that, with the right people involved with a security mindset, we could put in systems in place that actually monitor activity." "And could plausibly actually make it less dangerous for things to be automated than for folks working in the average university lab who might be susceptible to wanting to build something dangerous." @IFP
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