https://xitter.cf/t.co/pKiygx6Uda is a crowd-sourced mass spectral database for HRMS screening of new psychoactive substances (NPS). Email highresnps@gmail.com to join!
University of Copenhagen
Joined July 2019
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The HighResNPS team would like to thank @TIAFT_Tweets for supporting us and allowing this project to continue. This project could not have gone ahead without those at the University of Copenhagen who created this resource in addition to the data provided by our valuable users.
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Thank you to Aaron Shapiro on including HighResNPS in yesterday's edition of the Forensic Lab Talks hosted by @WileyGlobal , @The_AAFS and @JFS.
Title: High Performance Computing Tools to Identify Novel Psychoactive Substances in Toxicology Samples
The HighResNPS June/July 2024 libraries are now available for download.
The libraries contain 2,326 compounds (+3), of which 1,666 have at least one product ion (+8).
We now have 448 users from 47 countries, with Bahrain recently added to this list.
HighResNPS retweeted
UNODC considers designer benzodiazepines (DBZD) to be a current primary threat among NPS. Castle et al. (incl. @dgerostamoulos) reported the detection of a new emerging DBZD, clobromazolam, using HRMS and the HighResNPS.com database. Read it all➡️bit.ly/3QLD2Nb
HighResNPS retweeted
New #opensource workflow for analysis of emerging drugs in wastewater. Linked #InSpectra (thanks @Dr_J_OBRIEN, @SSamanipour, @WelshBoffin and Denice!) with #HighResNPS (thanks @dpasin117!) to detect #NPS and drugs of abuse from 47 sites in 16 countries.
sciencedirect.com/science/ar…
Use of @HighResNPS to detect Clobromazolam in Australian Emergency Departments.
academic.oup.com/jat/advance…
The October 2023 libraries are now available for download on highresnps.com.
The libraries contain 2,329 compounds (+11), of which 1,658 have at least one product ion (+18).
Always nice to see the database being used in action and yielding positive results! Thank you @bobsmedog and @strobbia for your work!
Trobbiani, @bobsmedog & Kostakis developed a method for screening SCRAs and opioids in whole blood by LC-QTOF-MS with simultaneous suspect screening using the @HighResNPS database. The method was applied to 61 forensic cases. Want to know what they found?➡️bit.ly/3G0AkOg
If you see this, don't panic! We are currently migrating HighResNPS to a new home and we anticipate the website will be operational within the next 24 hours.
Taking stock of the HighResNPS membership. We currently have 371 users from 46 countries, with 54 users added this year.
Interesting work utilising WBE in institutions with alarming results.
Educational institutions should be safe-spaces with no use of psychoactive drugs. However, we detected and identified several #NewPsychoactiveSubstances via #WW analysis, #IMSHRMS and @highresnps databases sciencedirect.com/science/ar… #TajaVerovsek @IupaUji @LubertusBijlsma @JSI_SLO
Nice evaluation of the @HighResNPS database with predicted retention times and MS/MS spectra matching for routine analysis by @strobbia and @bobsmedog.
Definitely some food for thought on our end for future developments.
academic.oup.com/jat/advance…
If you're at @TIAFT 2023, be sure to check out Monday's lunch time scientific workshop by @Agilent:
“Combining compound information from the @HighResNPS with the Agilent LC/Q-TOF MassHunter Screening Tool for large-scale analysis of New Psychoactive Substances”
It's been a while⌛️, but the January 2023 libraries are now available in most major LC-HRMS library formats from HighResNPS.com.
This library contains 2,287 unique compounds of which, 1,604 have product ion data.
If you would like to share your success stories on using HighResNPS or simply provide feedback anonymously please feel free to fill out the form below 👇👇
forms.gle/o6BphmtngqRgmR8N6
Your responses will help us better understand the impact HighResNPS and how we can make it better.
Happy New Year! Admittedly the admins were a ~little~ slack last year in generating libraries, however, we will be providing new libraries in the next month after having received a large number of entries from @LukeRodda and his team in San Francisco!
If you have spectra of alpha-hydroxyclonazolam or alpha-hydroxyflubromazolam could you please DM us? We would be very grateful!
We are now using a centralised email address so if you have any questions or wish to be added to the database, please send an email to highresnps@gmail.com
Another great talk featuring HighResNPS for practical screning of NPS by @TIAFT_Tweets Board Member @smrwille.
