@HerzonLab

Student run twitter for the Herzon Lab @Yale

 New Haven, CT
herzongroup.org
Joined September 2018
  • Tweets273
  • Following146
  • Followers2.4K
63Media
Online today in the Journal of Natural Products! We used computational and statistical analysis tools to study alternative structures for chartellamides A and B resulting in the proposed structure revision of both isolates. pubs.acs.org/jnprdf/article/…

Computationally-Guided Structure Revision of the Chartellamides

Abstract. Chartellamides A and B are heavily oxidized marine alkaloids that were isolated by Christophersen and co-workers from the marine bryozoan Chartel

pubs.acs.org
1
7
580
Check out our recent study in @J_A_C_S. We developed a divergent synthetic platform enabling the total synthesis of (+)-pleuromutilin and access to >30 novel core-modified analogs with potential to target drug-resistant bacteria. pubs.acs.org/jacsat/article/…

A Platform for the Production of Pleuromutilin and Core-Modified Derivatives

Abstract. The structural complexity of pleuromutilin antibiotics has limited efforts to define aspects of the natural scaffold that are required for antiba

pubs.acs.org
3
18
3,034
It's a busy week in the Herzon Lab as we celebrate another successful Ph.D. defense, this time by Dr. Alexandria Palazzo! Check out some of her recent work here: pubs.acs.org/doi/abs/10.1021…
10
1,001
Congratulations to our very own Dr. Vaani Gupta for her successful PhD defense! She has worked on a number of projects, including our recent synthesis and biological evaluation of (–)-gukulenin A! Read more about her work here: science.org/doi/10.1126/scie… science.org/doi/10.1126/scie…
1
1
33
2,684
Check out our latest work on colibactin in ACS Chemical Biology. Congratulations to the whole team on their work! pubs.acs.org/doi/full/10.102…

Synthesis and Biological Evaluation of Colibactin Derivatives

Abstract. Colibactin is a pseudo-C2-symmetric gut microbiome metabolite that induces DNA interstrand cross-links and plays a causal role in colorectal canc

pubs.acs.org
2
8
85
4,505
Nice story about our GBM research by Yale Student Isabella Backman. There are few treatment options for these patients, and none are curative. We are rooting for Merck and Company and hope they'll be able to get these drugs into the clinic soon! medicine.yale.edu/news-artic…

For Families Battling Brain Cancer, New Treatment Brings Hope

A Yale spinout developed a new drug for treatment-resistant glioblastomas that could reach patients as soon as next year.

medicine.yale.edu
1
4
1,753
Researchers at @Yale, including Camille Dreyfus Teacher-Scholars Seth Herzon (@HerzonLab) and Jason Crawford, "have synthesized a complex, potentially cancer-fighting molecule found in sea sponges discovered off the coast of South Korea." news.yale.edu/2025/11/13/soa…

Soaking up the anti-cancer properties of a South Korean sea sponge

Yale researchers have completed a challenging synthesis of a molecule that may have potent anti-cancer effects.

news.yale.edu
2
3
994
Congratulations to our very own Dr. Zechun Wang for his successful PhD defense! In his time with us, he has worked on a multitude of projects, including our recent synthesis and biological evaluation of (–)-gukulenin A! Read about it here: science.org/doi/10.1126/scie…
1
15
2,021
Three-component assembly and structure–function relationships of (–)-gukulenin A by Vaani Gupta, Zechun Wang, Joshua B. Combs, Timothy Wright, Lei Chen, Boxu Lin, Ryan Holmes, Bo Qin, Joonseok Oh, Jason M. Crawford, and Seth B. Herzon @HerzonLab at @YaleChem in @ScienceMagazine science.org/doi/10.1126/scie…
21
1
84
6,285
Members of Yale's @HerzonLab have led the synthesization of a complex, potentially #cancer-fighting molecule found in #seasponges discovered off the coast of South Korea. #gukuleninA news.yale.edu/2025/11/13/soa… @SmilowCancer @YaleChem @ScienceMagazine

Soaking up the anti-cancer properties of a South Korean sea sponge

Yale researchers have completed a challenging synthesis of a molecule that may have potent anti-cancer effects.

news.yale.edu
2
8
1,035
Out now in Science: Three-component assembly and structure–function relationships of (–)-gukulenin A, as a first release research article. Congrats to the team! (1/4) science.org/doi/10.1126/scie…

Three-component assembly and structure-function relationships of (–)-gukulenin A

α-Tropolones comprise an unsaturated seven-membered ring bearing a hydroxyl substituent adjacent to a polarized carbon-oxygen π bond. This polarization imparts a permanent molecular dipole and...

science.org
4
17
3
98
15,814
more replies
We had many failed strategies and could have walked away from the project a half dozen times. We could not be more proud of the team on this. (3/4)
1
1
7
1,495
For a commentary on this work, check out this @cenmag piece written by @beth_halford: (4/4) cen.acs.org/synthesis/medici…

A guide to making gukulenin A

3-component assembly builds a natural product that could fight cancer

cen.acs.org
1
3
1,157
Out today in @J_A_C_S is the first synthesis from our group!! We report a convergent and stereoselective total synthesis of the nominal structure of Talaromyolide D. Huge congrats to Bo and Alex! @nyuchemistry @TotalSynthesis pubs.acs.org/doi/10.1021/jac…
21
51
10
344
48,826
Herzon Lab retweeted
Yulab@YulabJin14 Aug 2025
Absolutely beautiful !@MartinTomanik your team beats everyone in using these two bifunctional pyridone ligands for CH hydroxylation. The sp2 CH sp3 coupling with epoxide by MPAA ligand will also inspire more use of such sp2 Sp3 coupling. congrats ! @HerzonLab you trained him well
Martin Tomanik@MartinTomanik14 Aug 2025
Out today in @J_A_C_S is the first synthesis from our group!! We report a convergent and stereoselective total synthesis of the nominal structure of Talaromyolide D. Huge congrats to Bo and Alex! @nyuchemistry @TotalSynthesis pubs.acs.org/doi/10.1021/jac…
2
7
62
7,464
#TotalSynthesis of Chartelline C by Noah M. Bartfield (@NaOHBartfield), Brandon W. Alexander, and Seth B. Herzon @HerzonLab at @YaleChem in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
1
25
116
9,738
Total Synthesis of Chartelline C | Journal of the American Chemical Society @Yale @YaleChem pubs.acs.org/doi/10.1021/jac…

Total Synthesis of Chartelline C

Abstract. Chartellines are cytotoxic marine alkaloids that were isolated in the late 1980s. Their unique, heavily oxidized structures, comprising a spirocy

pubs.acs.org
12
90
6,611
The total synthesis of chartelline C! Accomplished in a small number of transformations from material intercepted en route to the securamines. Each step was informed by the unique topology and unconventional reactivity of these isolates 🥳🙌 pubs.acs.org/doi/10.1021/jac…

Total Synthesis of Chartelline C

Abstract. Chartellines are cytotoxic marine alkaloids that were isolated in the late 1980s. Their unique, heavily oxidized structures, comprising a spirocy

pubs.acs.org
2
3
1
54
2,503
Congratulations to our undergraduate trainee, Sam Charney, for receiving a 2025 Summer Undergraduate Research Fellowship from the ACS DOC!
ACS Organic Division@ACSorganic18 Apr 2025
The Division of Organic Chemistry (DOC) congratulates the sixteen 2025 DOC Summer Undergraduate Research Fellowship (SURF) awardees and gratefully acknowledges the generous sponsors. zurl.co/x1kZh
1
34
3,271
Load more