A shout out to a few people in the longevity community who've been great > @biogerontology collaborative and helpful > @geochurch is an awesome human > @davidasinclair welcoming and open > @aubreydegrey friendly and positive > @prof_horvath chill and curious > @DrMorganLevine generous and rigorous

I think people could live 300 years or more. David Sinclair has already reversed the age of mice with reprogramming. That work has since moved to dogs and primates. In our own work we're seeing about three to five years of age reversal for every year of treatment. Supplements like alpha-ketoglutarate, TMG and PQQ slow the aging process. Spermidine and fisetin help kill off older cells. Off-label drugs like tranylcypromine, valproic acid and sodium butyrate switch younger genes back on. Furthermore, I see aging and cancer as very similar diseases. Cancer cells carry many of the same receptors as old cells. The drugs that extend life expectancy also tend to fight cancer. As drugs and protocols that support longevity become more widely available, I believe people who reverse their age will be less likely to get cancer.

I put four longevity titans in one room for an hour, and they gave me four very different answers on when we’ll beat aging. They challenged each other on timelines, the FDA, AI, and the hype problem in longevity science. Watch @aubreydegrey, @biogerontology, @geochurch, and @M_S_Ringel battle it out, live now on The Beyond Tomorrow Podcast!

The global era of Don't Die begins in 2030. New age reversal therapies will emerge and automation will run our lives, removing the biggest blockers of health: discipline and effort. Death acceptance will vanish as fast as body positivity did with GLP-1s.

Here at Harvard Medical School with @davidSinclair celebrating the 25th anniversary of his lab! thank you, david for your brilliant work on age rehearsal!

We had a fabulous Formal Research Seminar today at the Buck! Dr. Peter Adams @AdamsBioAging was our guest speaker today, visiting us from @sbpdiscovery in La Jolla. It was an exciting seminar on epigenetics, cancer and aging. We look forward to having you back soon Dr. Adams!

Longevity escape velocity is the point where medicine adds more than one year of healthy life for every year that passes. That is a concrete public target. Once life expectancy rises faster than time, aging becomes a solvable engineering problem. Should longevity escape velocity be an explicit government research goal, yes or no?

do you think aging a disease?

New news: Life Biosciences will present first-in-human data from the Phase 1 trial of ER-100 in optic neuropathies at the Eyecelerator Conference in New Orleans, Oct, 8, 2026, 2:10PM CT 👀

we're probably 6–18 months away from a world where: - obesity is basically solved - balding actually gets fixed, real hair regrowth - biological age becomes something you can push backwards - fertility stops being locked to a biological countdown clock - cancer treatment looks less like chemo and more like software: sequence the tumor, design the fix, treat it - some genetic diseases get erased with a single treatment - lab-grown organs become a real option - drugs get designed faster than human teams can test them - autonomous labs run thousands of experiments overnight while everyone sleeps - your doctor gets a biological dashboard that catches disease before you feel a symptom - personalized medicine means getting a treatment designed specifically for your biology 2026 is changing the stakes we're extrapolating from things that are already working bio/acc

Rounding off with Vadim Gladychev As realist as they come with his predictions for longevity escape velocity.

in the next 3-5 years: - balding gets solved, real treatments after decades of basically nothing - testosterone gets adjustable, no more "normal for your age" - fertility gets decoupled from the biological clock - organs get lab-grown, a real option instead of a waitlist - genetic disease gets edited instead of managed for life - aging gets its first credible human signals of partial reversal - the immune system gets programmed to clear the cells driving age-related disease - biological age becomes something you can actually move backwards - cancer gets more tumors that are treatable, some potentially curable we're already watching the first versions of all of this happen bio/acc

curing aging should be a bigger priority than sending humans to mars

Dr. @misraetel's case for why age reversal will reach everyone, fast: Old people run the world. They run corporations and governments, and none of them want to die. So when age reversal therapies hit trials, they'll fund them, not block them. And once they have it, keeping it from everyone else becomes politically impossible.

This is the century of biotechnology. That's all.

One of the wildest conversations I've had, and it's out tomorrow. Despite being on steroids, @misraetel believes if he can make it to 50, age-reversal tech will take care of the rest. Covering GLP-1s, looksmaxxing, genetic engineering, why he thinks superintelligence is going to "take us to the f**king stars" and much more. Live at 9am EST / 2pm BST Thursday 23rd September - The Beyond Tomorrow Podcast

I've focused for 25 years on aging damage repair, many of them while it was viewed as unscientific. Not any more! In December I oversee the Friday program at the Trampoline Zermatt Summit, with about 100 founders, investors and scientists. 2-6 December, by invitation.

Aging is the most destructive pathophysiological phenomenon known to humanity. It drives disease, disability, and suffering on an immense scale. If we can stop it, we have a moral obligation to do so. That's all.