@HeldweinLab

We are structural biologists @TuftsMedSchool exploring how specific proteins contribute to the lifecycle of #herpesviruses. Postdoc-curated account.

 Boston, MA
heldweinlab.com/
Joined July 2018
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  • Followers331
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It's been an exciting start to 2024 with publication of Lizzy and Gonzo's work on structure of the NEC's suppressor mutation and such a wonderful academic year of rotation students - see more updates and fun on heldweinlab.com SUP paper here: doi.org/10.1371/journal.ppat…
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Congratulations to Lab Alum @ebdraganova on selection for the New Innovator Award!
NIH Common Fund@NIH_CommonFund3 Oct 2023
Early-stage investigators proposed innovative high-impact research ideas for the @NIHDirector’s New Innovator Award. See the projects the awardees will pursue: commonfund.nih.gov/newinnova… #NIHHighRisk
Collage of photos of all the 2023 NIH Director's New Innovator Awardees

ALT Collage of photos of all the 2023 NIH Director's New Innovator Awardees

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Say "Conformational Dynamics!" Congrats to Leah on her successful qualifying exam defense!!
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Congratulation to our @ACalderonZavala for Best Flash Talk at the MCCET Tomography workshop
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We had some really good *ice* last night 😅 love some cryo-jokes
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Delayed appreciation post for all the folks at @GordonConf Physical Virology - Katya, @J_Martin_R and @NathalieRLavoie had a great time! Lucca is gorgeous!
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Oh the tegument outside is delightful But my DNA inside is frightful And since I've got a glycoprotein coat I can even infect a goat! ~~ Real proud of the Heldwein Lab's 2022 Most Scientific Gingerbread House Award!~~
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Excited to see @ZemplenPataki's thesis work published in mBio journals.asm.org/doi/10.1128…
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We're so excited to see what's next for the Draganova lab!
Elizabeth (Lizzy) Draganova@draganovalab19 Aug 2022
Just spent the afternoon saying goodbye to the @HeldweinLab. How fast time flies. I started my postdoc with zero confidence I could ever land a job in academia. What a journey it’s been - looking forward to this next adventure! #newPI #AcademicChatter @PostdocVoice
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Congratulations to the newest Heldwinners on passing their qual exams! @ACalderonZavala & #maria!
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#maria has upgraded to @MDKrasilnikov !!
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Wonderful poster presentation from our summer BDBS student at the #TuftsS2P2_2022 today Great work Ama! (pictured w her *very proud* mentor @NathalieRLavoie)
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Thank you for being part of the lab, @artbyama!
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Shoutout to our Heldwinner @ZemplenPataki for being recognized as an OUTSTANDING Tufts School of Medicine Instructor! #GOAT
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#TeamEgress is at it again! Congratulations @thorsenm12 and @ebdraganova for their work in @PLOSPathogens showing that the gammaherpesvirus EBV nuclear egress complex intrinsically buds membranes and does so by an oligomerization-driven mechanism. journals.plos.org/plospathog…

The nuclear egress complex of Epstein-Barr virus buds membranes through an oligomerization-driven...

Author summary Herpesviruses, which infect most of the world’s population for life, translocate their capsids from the nucleus, where they are formed, into the cytoplasm, where they mature into...

journals.plos.org
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Published!! Check out @ZemplenPataki's work in @PLOSPathogens on how we think HSV-1 gH activates the gB fusogen. Great work! #herpesvirus #teamentry #lovevirology journals.plos.org/plospathog…

A surface pocket in the cytoplasmic domain of the herpes simplex virus fusogen gB controls membrane...

Author summary Herpes simplex virus 1 (HSV-1) establishes lifelong infections in over a half of people and causes diseases ranging from oral or genital sores to blindness and brain inflammation. No...

journals.plos.org
Heldwein Lab@HeldweinLab16 Mar 2022
Congratulations to our MD/PhD student @ZemplenPataki on this exciting study! Here, we propose a mechanism for how HSV-1 gH activates the fusogenic activity of gB - a pathway that could be shared by other gB homologs. #lovevirology #herpesvirus #teamentry
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We are sending another Heldwinner out into the world - congratulations @ZemplenPataki on the successful defense of your thesis! We are so proud of your accomplishments and are excited to see you embark on your next title as MD. #doubledoc #herpesvirus #phd
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We are very proud of our Heldwinner @ZemplenPataki! Check out what we've learned about HSV-1 membrane fusion. #lovevirology #teamentry #herpesviruses
Zemplén Pataki, MD, PhD@ZemplenPataki9 May 2022
My 2nd first-author pre-print is now available. We found that HSV-1 viral entry glycoproteins interact extensively before and during fusion, refining our understanding of the molecular mechanism of HSV-1 membrane fusion @HeldweinLab #herpes #virology biorxiv.org/content/10.1101/…

Herpes simplex virus 1 entry glycoproteins form stable complexes prior to and during membrane fusion

Herpesviruses – ubiquitous pathogens that cause persistent infections – have some of the most complex cell entry mechanisms. Entry of the prototypical herpes simplex virus 1 (HSV-1) requires coordi...

biorxiv.org
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A big congratulations to our postdoc and @TuftsIRACDA fellow @ebdraganova on her new faculty position! We are all so proud and look forward to reading papers about herpesvirus nuclear egress and capsid assembly from the Draganova lab!!
Elizabeth (Lizzy) Draganova@draganovalab28 Apr 2022
I’m so happy to share that I’ll be joining @EmoryBiochem @EmoryUniversity as an Assistant Professor this fall! Looking forward to combining my love of chemistry with biophysics to study aspects of herpesviral nuclear egress and capsid assembly. 1/7
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Congratulations to our MD/PhD student @J_Martin_R who was awarded the Spring Student Enrichment Fund Travel Award to attend the @FASEBorg Virus Structure and Assembly Conference this summer! #VSA2022 #herpesviruses
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