@Helaway

PharmD, dont ever think I dont ask questions! No conflicts ($)- just save humans and animals! Peace!

 USA
Joined April 2009
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A new study led by researchers at Brigham and Women’s Hospital and Harvard Medical School suggests that Long COVID may involve a disruption in the body’s ability to resolve inflammation. Researchers analyzed blood samples from 106 people following SARS-CoV-2 infection and found that those who developed Long COVID had increased activity of enzymes called lipoxygenases, which metabolize essential fatty acids involved in regulating inflammation 1/
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Just Looking.. FYI YDY Peace xitter.cf/i/grok/share/c2hhcmQtN…

I had some thoughts about soem things missing from the paper- and I kn...

Your synthesis is a thoughtful attempt to connect the adaptive T-cell findings in the Painter/Wherry preprint to upstream innate and vascular drivers that standard PBMC-focused studies largely miss. It aligns with several active research threads, particularly around megakaryocytes as potential reservoirs, while some of the mechanistic links remain more speculative. Here’s a structured take. Strongly supported elements Megakaryocyte infection and platelet transfer There is solid evidence that S...

Answer by Grok
Mark Painter@markmpainterOct 17
Our study on virus-specific T cell activation in Long COVID (LC) is up on bioRxiv! We identify a subset of people with LC with persistently elevated activation of CD8 T cells targeting spike and/or EBV lytic antigens, consistent with viral persistence. biorxiv.org/content/10.64898…

Persistently activated virus-specific CD8 T cells indicate antigen-driven immune aberrations in...

Long COVID (LC) affects millions of people worldwide, yet its driving mechanisms remain incompletely defined and no treatment has been approved. Persistence of SARS-CoV-2 and reactivation of herpes...

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supar, p xitter.cf/i/grok/share/c2hhcmQtN…

Elevated circulating levels of soluble urokinase plasminogen activator...

Refined suPAR paragraph (manuscript-ready) Elevated circulating levels of soluble urokinase plasminogen activator receptor (suPAR), the shed form of the Ly6/uPAR-family member uPAR (PLAUR), represent a consistent and clinically actionable indicator of pathway dysregulation in SARS-CoV-2 infection. Multiple cohorts and meta-analyses demonstrate that plasma suPAR rises early after infection and scales with disease severity, independently associating with progression to acute respiratory distress s...

Answer by Grok
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Yust FYI P xitter.cf/i/grok/share/c2hhcmQtN…

As you mentioned, vWF is also cleaved by furin- but I bet the author d...

Yes, you're right — von Willebrand Factor (vWF) is a well-established furin substrate.<grok:render card_id="51b85e" card_type="citation_card" type="render_inline_citation"><argument name="citation_id">15</argument></grok:render> vWF processing by furin vWF is synthesized as pre-pro-vWF. The propeptide (vWFpp, domains D1-D2) is cleaved by furin (also called PACE) in the trans-Golgi network at a dibasic site. After cleavage, the propeptide remains non-covalently associated with mature vWF multimer...

Answer by Grok
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TWiV 635: Mask hysteria youtu.be/omd29lXspuk?si=Cb_s… via @YouTube

TWiV 635: Mask hysteria

Daniel Griffin provides a clinical update on COVID-19, then we revi...

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Not about mask. Listen. YDY P
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Some good techniques here. Id save it in the archives! YDY Peace! xitter.cf/i/grok/share/c2hhcmQtN…

Vagus nerve stimulation (VNS), is there a manual way to do this, some ...

Yes, there are several manual maneuvers and techniques that can stimulate the vagus nerve (or increase vagal tone/parasympathetic activity). These range from classic medical “vagal maneuvers” used in clinical settings to simpler, everyday methods. Classic medical vagal maneuvers These are primarily used to temporarily increase parasympathetic (vagal) output to the heart, often to help terminate certain types of stable supraventricular tachycardia (SVT). They work by raising intrathoracic pressur...

Answer by Grok
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Some reasons why... P xitter.cf/i/grok/share/c2hhcmQtN…

Cholinergic Antiinflammatory Pathway (CAP) =reDO!!

Yes — activating or pharmacologically supporting the Cholinergic Anti-inflammatory Pathway (CAP) can dampen ferroptosis in several inflammatory and injury contexts, including lung injury models relevant to severe infections. The CAP is the efferent arm of the inflammatory reflex: vagus nerve signaling leads to acetylcholine (ACh) release that acts primarily on α7 nicotinic acetylcholine receptors (α7nAChR) on macrophages, microglia, and other cells. This suppresses pro-inflammatory cytokine prod...

Answer by Grok
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Ya might want to save this print. YDY Peace
Association Winslow Santé Publique@winslow_laOct 9
Revue de la littérature (2020-2026) sur les problématiques endocriniennes liées au COVID, que ce soit en phase aigue ou chronique #COVIDlong. Le virus pénètre via les récepteurs ACE2, dont l'expression est élevée dans plusieurs tissus endocriniens, academic.oup.com/jes/article…
Schéma montrant le corps humain et les effets endocriniens du SARS-CoV-2 sur l’hypothalamus/hypophyse, la thyroïde, les parathyroïdes, le pancréas, les surrénales, les gonades et les os, avec des encadrés sur hypopituitarisme, troubles thyroïdiens, hypocalcémie, diabète/hyperglycémie, insuffisance surrénalienne et baisse de la fertilité. À droite, un encadré « Viral Entry Mechanism » illustre l’entrée virale via les protéines Spike, ACE2, TMPRSS2 et ADAM17, ainsi qu’un encadré « Mechanisms » sur invasion directe, inflammation, auto-immunité et effets médicamenteux.

ALT Schéma montrant le corps humain et les effets endocriniens du SARS-CoV-2 sur l’hypothalamus/hypophyse, la thyroïde, les parathyroïdes, le pancréas, les surrénales, les gonades et les os, avec des encadrés sur hypopituitarisme, troubles thyroïdiens, hypocalcémie, diabète/hyperglycémie, insuffisance surrénalienne et baisse de la fertilité. À droite, un encadré « Viral Entry Mechanism » illustre l’entrée virale via les protéines Spike, ACE2, TMPRSS2 et ADAM17, ainsi qu’un encadré « Mechanisms » sur invasion directe, inflammation, auto-immunité et effets médicamenteux.

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The current wave in the Pacific is massive. I just measured it over a 1500 miles from the coast of Cali
#Anonymous
@TheStripesGirlOct 12
This is what happens when you are dealing with a massive Kelvin wave...
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YA Talk Talk - It's My Life (Official Video) youtu.be/cFH5JgyZK1I?si=HyGU… via @YouTube

Talk Talk - It's My Life (Official Video)

Official 4K upgraded video for It's My Life by Talk Talk.Order th...

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i found creatures, or just clicks on a camera.. I call this ' SeaDog".
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Cant make heads or tails of it!! Aging is real!
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Always get myself underwater! xitter.cf/i/grok/share/c2hhcmQtN…

Draft the suPAR paragraph for the manuscript

Draft paragraph for insertion (e.g., under the calcium–coagulation axis or biomarker/therapeutic convergence section): Elevated circulating levels of soluble urokinase plasminogen activator receptor (suPAR), the shed form of the Ly6/uPAR-family member uPAR (PLAUR), represent a consistent and clinically actionable indicator of pathway dysregulation in SARS-CoV-2 infection. Multiple cohorts and meta-analyses demonstrate that plasma suPAR rises early after infection and scales with disease severity...

Answer by Grok
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Mood. The B-52's - Rock Lobster (Official Music Video) youtu.be/n4QSYx4wVQg?si=0KHF… via @YouTube

The B-52's - Rock Lobster (Official Music Video)

You're watching the official music video for The B-52's - "Rock Lob...

youtube.com
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Classics.. Talking Heads - Burning Down the House (Official Video) youtu.be/_3eC35LoF4U?si=ALqo… via @YouTube

Talking Heads - Burning Down the House (Official Video)

Watching the official music video for Talking Heads - "Burning Down...

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A full day after landfall, what's left of Isaias did this. The red streak is the storm's rotation on radar, the blue dots are WeatherWise storm chasers, and a tornado was confirmed along it again and again for three and a half hours.
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Ya DEVO Girl U Want (Official Music Video) youtu.be/g4-2onb62y8?si=Rqcw… via @YouTube

DEVO Girl U Want (Official Music Video)

Directed by Gerald V. Casale year: 1980ClubDevo.com

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