@Heissler_Lab

Assistant Professor. Myosin enthusiast. Fascinated by molecules and cells. Opinions are my own.

 Columbus, OH
Joined March 2019
  • Tweets119
  • Following227
  • Followers169
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Our latest research on dysferlin has just been published. @Heissler_Lab. nature.com/articles/s41467-0… #membrane_repair #dysferlin #dysferlinopathy

Cryo-EM structures of the membrane repair protein dysferlin

Nature Communications - Dysferlin is essential for plasma membrane repair, and mutations in this protein cause various muscle diseases. Here the authors report the structure of dysferlin, offering...

nature.com
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Heissler Lab retweeted
Simon Duerr@simonduerr28 Oct 2024
This is great! @NIAIDNews have launched a collection of public domain illustrations (currently 550 individual icons) bioart.niaid.nih.gov/
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In Memoriam: Remembrance of Robert S. Adelstein: Mr. Nonmuscle Myosin 2 @CytoskelJournal onlinelibrary.wiley.com/doi/…
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Cryo-EM structures of cardiac muscle α-actin mutants M305L and A331P g... sciencedirect.com/science/ar… Our work on cardiac actin mutants A331P and M305L is now published. Great collaboration with @Heissler_Lab @SPOREMOHAN labs.
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Remembrance of Edward D. Korn: A Pioneer in Our Field onlinelibrary.wiley.com/doi/… @CytoskelJournal #NIH #myosin #cell
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doi.org/10.1007/s00018-024-0… Our review on nonmuscle myosins is out.

Structure, regulation, and mechanisms of nonmuscle myosin-2

Cellular and Molecular Life Sciences - Members of the myosin superfamily of molecular motors are large mechanochemical ATPases that are implicated in an ever-expanding array of cellular functions....

link.springer.com
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Pleased to share our work (Pinto, Bakker, Suchenko et al) on structural and functional characterization of Actin arginylation. Collaboration between @SPOREMOHAN @zkrna @CellAdhesion @midbody biorxiv.org/content/10.1101/…
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The Zanic Lab@ZanicLab23 Apr 2024
We hope you will join us for the Vanderbilt - Warwick Mechanobiology Symposium @TheVCoM @Warwick_CMCB @VUBasicSciences @VUEngineering @VanderbiltCDB
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NEW AT CYTOSKELETON @cytoskeljournal. NO EDITORIAL (Desk) REJECTIONS if your paper is within the journal’s scope. IT WILL GO OUT FOR REVIEW! We want your papers. #FREE to publish. #CYTOSKELETON is your home for ALL cytoskeletal research. #microscopymonday onlinelibrary.wiley.com/page…
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AMAZING! No word limits or figure limits for #researcharticles and #Reviews at Cytoskeleton @CytoskelJournal. #publishing is always #FREE!!! Send us your work. We want your papers! No need for supplementary figures, put them in the body of your papers.
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M@Michelle__Baird22 Dec 2023
🚨🚨🚨 BEYOND excited to share the preprint of my work looking at LBR mediated cholesterol accumulation in the NE causing fragility! A huge huge thanks to my coauthors and the Waterman Lab for all the support over the years 💕🥳 biorxiv.org/content/10.1101/…

Lamin B Receptor Upregulation in Metastatic Melanoma Causes Cholesterol-Mediated Nuclear Envelope...

Metastatic cancer cells migrate through regions of tissue confinement, causing nuclear envelope (NE) rupture and heritable DNA damage. We discovered that cells from multiple cancers have increased NE...

biorxiv.org
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My latest review on the endonuclease activity of AGOs was published @jbiolchem. I propose the composite target-binding channel while discussing the conformational changes for catalytic activation, the possible roles of metal ions, and their evolution. jbc.org/article/S0021-9258(2…

When Argonaute takes out the ribonuclease sword

Argonaute (AGO) proteins in all three domains of life form ribonucleoprotein or deoxyribonucleoprotein complexes by loading a guide RNA or DNA, respectively. Since all AGOs retain a PIWI domain that...

jbc.org
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Logue Lab@JeremyLogue121 Sep 2023
We've added important new data to our recent pre-print (biorxiv.org/content/10.1101/…). While cells in confinement without INF2 firmly adhere to the micropattern, cells with INF2 will cross over the micropatterns using fast amoeboid (leader bleb-based) migration:
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LeritLab@LabLerit27 Jul 2023
🚨Faculty Job Posting🚨 TT Assistant Prof at U. Richmond with fabulous colleague, mentor @_OmQu richmond.csod.com/ux/ats/car…
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We've had an incredible response to our call for papers for the Special Issue on #Myosin and Myosin-Dependent #Cell Processes in @cytoskeljournal . There is still plenty of time to put together your submissions. Submit any time before Dec. 1, 2023. cytoskeletonjournal.com
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Structural insights into actin isoforms. #CryoEM elifesciences.org/articles/8…
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Do you have a good, solid piece of work on ANY aspect of the #cytoskeleton? If so, we want your papers. It’s #FREE to publish in Cytoskeleton @CytoskelJournal ! cytoskeletonjournal.com #microtubules, #actin, #intermediatefilaments, #septin, #spectrin, #cell, #research
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Happy to see @CellAdhesion protein used for the virtual ribbon cutting for the new Pelotonia Research Center today @OhioStateMed @OSUWexMed @OhioStatePCB
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Official Ribbon Cutting Ceremony for the opening of OSU brand new research facility the Pelotonia Research Center with DHLRI having brand new space on the 5th floor. Congrats to Krishna Chinthalapudi for making the “ribbon”! @OhioStateDHLRI @CellAdhesion @PeterMohler
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An NIH-funded postdoctoral position - looking for cell biologists/biophysicists etc. interested in cell biology of genetic #KidneyDisease, #podocyte biology, or cellular biophysics of renal filtration and #phagocytosis. Syracuse/Central NY offer affordable living & outdoor fun.
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