PI: Yong He @ IDG/McGovern Institute for Brain Research, and State Key Lab of Cognitive Neuroscience and Learning, Beijing Normal University.

People's Republic of China
Joined June 2019
Check our latest preprint! biorxiv.org/content/10.1101/… We present the first population-specific brain charts for China, developed through the Chinese Lifespan Brain Mapping Consortium (Phase I) using high-quality MRI data from 43,037 participants (aged 0-100 years,384 sites). (1/6)
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🚨New research out! We introduce Functional Topography Covariance Analysis (FOCA), a framework to quantify the spatial coordination of individualized brain networks and further delineate its developmental origins. doi.org/10.1093/psyrad/kkag0…
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(5/6) Moreover, neonatal FOCA encodes brain development at birth period and neurodevelopmental outcomes at 18 months.
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(6/6) Finally, by comparing FOCA and conventional functional connectivity matrices, we found that FOCA showed lower susceptibility to global signal regression, retained richer inter-individual variability, and was more sensitive to the development of negative couplings.
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Check out our latest work exploring the convergent and divergent spatial topographies of individualized brain functional networks and their developmental origins! by @jianlong6 @Tengdazhao
🚨 New preprint out! biorxiv.org/content/10.1101/… We introduce a framework that maps convergent (positive) and divergent (negative) spatial topographies of individualized brain networks—and shows how these interactions reverse in newborns and change across development. Thread⬇️
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💐Thrilled to share our latest work: Dissecting human cortical similarity networks across the lifespan. 🧠0–80 years 👏Grateful to all my amazing collaborators!
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These data provide a blueprint for elucidating the principle of cortical network reconfiguration and a benchmark for quantifying interindividual network variations. (7/8)
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Many thanks to all collaborators and data contributors!! (8/8)
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YongHe_lab retweeted
1/11 Excited to share our @Naturestudy led by @Leon_Oo1 @csabaorban @ZShaoshi doi.org/10.1038/s41586-025-0… It is well-known that AI performance scales with logarithm of sample size (Kaplan, McCandlish 2020), but in many domains, sample size can be # participants or # measurements...
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These Chinese-specific brain charts outperform Western-derived models in predicting Chinese healthy brain phenotypes and detecting pathological deviations in Chinese clinical cohorts(Alzheimer’s, schizophrenia, and depression). (5/6)
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These population-specific brain charts not only reveal biologically significant East-West divergences in maturation timelines, but also establish a scalable framework for developing ethnically-specific standards worldwide - an essential step toward truly precision medicine. (6/6)
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