@Harwell_Lab

Developmental neurobiology lab at UCSF. Account maintained by lab members. Lab website coming soon, as it has been since 2013...

 San Francisco, CA, USA
Joined November 2017
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Hi everyone. We haven't been too active on here lately (more on that soon), but we have still been doing some great science. The latest paper from our lab, led by the exceptionally talented @YajunXie is finally out at @NatureNeuro! Short summary below... nature.com/articles/s41593-0…

Astrocyte specification in the mouse septum is shaped by both developmental origin and local signals

Nature Neuroscience - The relative contribution of intrinsic and extrinsic factors to astrocyte heterogeneity is unknown. Using heterotropic transplantation of septal astrocytes with distinct...

nature.com
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This study highlights the diversity and plasticity of astrocytes - these beautiful cells that form constellations throughout the brain and contribute crucially to circuit development, maintenance and function, can bloom wherever they are, regardless of where they came from
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Many thanks to everyone involved in the study, to our wonderful collaborators @UCSFstemcell, @ChanZuckerberg, @dgsomucla (@yezhangyezhang) and our funding sources, particularly the grants from @NIH, without which none of this work would be possible.
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I'm so excited to share my first preprint from @Lab_Pollen at @UCSF on the phylogenetic and spatial distribution of TAC3 interneurons. This story was an adventure filled with twists and turns we never saw coming. Check out the preprint and a summary below! biorxiv.org/content/10.1101/…

Conservation, alteration, and redistribution of mammalian striatal interneurons

Mammalian brains vary in size, structure, and function, but the extent to which evolutionarily novel cell types contribute to this variation remains unresolved1–4. Recent studies suggest there is a...

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Please check our newest study on @biorxivpreprint - a tour de force led by the phenomenal @Chris_M_Reid, describing the diversity of neurons in the lateral septum in terms of transcriptomics, anatomical distribution, connectivity and electrophysiology: biorxiv.org/content/10.1101/…

Multimodal classification of neurons in the lateral septum

The lateral septum (LS) is a nucleus in the ventral forebrain that modulates complex social and affective behaviors. Several distinct neuronal types have been described in the LS; however, the full...

biorxiv.org
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If you want to know a bit more about Corey, please check this interesting piece in @NatureNeuro, where he discusses his background and career path with @sharilwiseman: nature.com/articles/s41593-0…
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(funnily enough, Corey complained about how big his face looked on the preview when we posted the link on Slack, and it turns out to be *even bigger* here... Sorry, boss!)
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Harwell Lab retweeted
Yajun Xie@YajunXie11 Oct 2023
Thank you all!AND We are still collecting feedback!🤗
Harwell Lab@Harwell_Lab10 Oct 2023
Another preprint from the lab! We dive deeper into the septum, exploring its astrocyte diversity. The fantastic @YajunXie led this impressive project to answer a BIG question: is it nature or nurture for astrocyte specification? Take a look to find out! biorxiv.org/content/10.1101/…

Developmental origin and local signals cooperate to determine septal astrocyte identity

Astrocyte specification during development is influenced by both intrinsic and extrinsic factors, but the precise contribution of each remains poorly understood. Here we show that septal astrocytes...

biorxiv.org
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Another preprint from the lab! We dive deeper into the septum, exploring its astrocyte diversity. The fantastic @YajunXie led this impressive project to answer a BIG question: is it nature or nurture for astrocyte specification? Take a look to find out! biorxiv.org/content/10.1101/…

Developmental origin and local signals cooperate to determine septal astrocyte identity

Astrocyte specification during development is influenced by both intrinsic and extrinsic factors, but the precise contribution of each remains poorly understood. Here we show that septal astrocytes...

biorxiv.org
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Here is the latest from the lab! Our first preprint since we moved to UCSF, but it has been in the works for some time - we first noticed this exciting phenotype (see Figure 1) almost seven years ago, and have been intrigued and fascinated by the septum ever since...
Miguel Turrero García@miguel_turrero25 Sep 2023
I’m so excited to share the results of our long-running project. Wonder what happened when we (unexpectedly) removed Nkx2.1-lineage neurons from the lateral septum? Well, it started like that, then grew and grew… Here’s the pre-print - we look forward to any and all feedback!
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Huge congratulations to Dr. Simon! We are all really looking forward to having Rhiana join us for her postdoc - and to her upcoming (and fantastic!) paper as well...
Rhiana C Simon, PhD@mouse_braind7 Jun 2023
It finally happened. After 7 years, I'm finally a doctor 🥳 Many thanks to @gstuber for his wonderful mentorship over the years! I'm so excited to next start my postdoc over at the @Harwell_Lab in a couple months!!
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Are you interested in what #astrocytes do in the context of synapses and white matter of the 🧠? We wrote a review for that! You can read the open access version here: nyaspubs.onlinelibrary.wiley…

NYAS Publications

Astrocytes play integral roles in the regulation and coordination of neural activity. These glial cells are a heterogeneous cell type, occupying functional niches throughout the brain. Not surprisi...

nyaspubs.onlinelibrary.wiley.com
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