The Halfmann Lab explores the cellular and evolutionary implications of protein self-assembly.
Kansas City, MO
Joined September 2015
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"Set Phasers to Kill." Derek Lowe's take on our @eLife paper on phase change batteries and cell death is as accurate as it is engaging. Impressed and grateful for the coverage @ScienceMagazine! science.org/content/blog-pos…
YOUR work, Alex! After years of effort and teasing apart what we've actually uncovered here, I'm so glad we can finally plant our flag on this discovery. Excited to see if other proteins function like batteries.
Halfmann Lab retweeted
Alex Von Schulze, postdoc in the @HalfmannLab, is exploring how proteins clump together to form disease-linked amyloids, and why collaboration is the key to scientific discovery. 🧠 #neuroscience
Learn more in this #PostdocProfile Q&A: bit.ly/4momNmV
MD simulations let you watch a microsecond or so of one protein's life in a box. But in the cell thousands of proteins work together, over much longer timescales. With @IlyaVakser's group and their new simulation method, GCell, we're now beginning to see this emergent behavior!
Delighted to share #MyACSCover and our recent study, "Highly Optimized Simulation of Atomic Resolution Cell-Like Protein Environment", published by @ACSPublications in J of Phys Chem B.
Congratulations to Prof. @IlyaVakser , @HalfmannLab , and the team!
doi.org/10.1021/acs.jpcb.4c0…
Halfmann Lab retweeted
1/n Can LLMs perform scientific research? And, can they do so while enhancing key scientific values including transparency, traceability & verifiability? Check out our preprint on the "data-to-paper" platform. w the amazing @TalIfargan @LostInTranscrip arxiv.org/abs/2404.17605
Halfmann Lab retweeted
Meet a #StowersGrad faculty member! Randal Halfmann (@HalfmannLab) seeks to understand #aging, the inexorable decline in cellular and bodily function that results from the unidirectional nature of self-assembly by supersaturated proteins. #PhD
Learn more: bit.ly/43TtyVw
Kudos also to a responsive editorial staff, who offered to provide Senior Editorial oversight in the second round of review. I feel empowered to refocus on science rather than academic politics – this feels like the future of science publishing. @ASAPbio_
Thank you, @eLife, for transparent review!
Exercising the power to publicly address a reviewer’s untenable position changed the outcome for our latest paper, the findings of which are recognized as “fundamental” by eLife’s updated assessment.
elifesciences.org/reviewed-p…
Great job Justin! Now we just need the yeast to write their own paper. #CRC23
Yes, science is FUN! (even for the nerds sitting in the corner with a calculator ;) Kate, thanks for helping make science accessible to everyone!
#ICYMI: Today @HalfmannLab and @K8theChemist joined @adavalostv on @GreatDayKC to talk all things #STEMeducation and @seekingascipod, our #podcast with @kcur. 🎙️ @fox4kc
📺 Watch here: bit.ly/3r6OSaS
Echoing Lorena- Hilal, your keynote on night 1 beautifully set the scene for the rest of the conference. Thank you so much! Looking forward to 2025.
Ron is a pioneer on the mechanism of polyQ aggregation, and an inspiration to me. It was a nice surprise that our new in-cell method validated his twenty year-old model derived from rigorous test tube experiments. Good science stands the test of time!
#ICYMI: New #research from the @HalfmannLab revealing the start of #Huntingtons disease published in @eLife. Here is what Ron Wetzel, PhD, @PittTweet @UPMC, had to say about the findings.
Read more: bit.ly/43XnOsB
#ScienceTwitter #Discovery
Proud moment in the life of an academic -- first @StowersGrad PhD student from my lab. @arg_arginine - you set a high bar!
Now out in eLife – our epic journey into the heart of polyQ to deduce the structure of an amyloid nucleus. Spoiler: it’s not #LLPS. Even more surprising, oligomerization blocks nucleation!
“One of the big mysteries of #Huntingtons, #Alzheimer’s, and #ALS is why disease coincides with amyloid, yet the amyloids themselves are not the main culprits.” @HalfmannLab discusses new #research published in @eLife.
Read here: bit.ly/43QTDUF
#ScienceTwitter
Ok Pickle. Months of head scratching and I think we finally know how the yeast are doing it. The awesome power of yeast cannot be contained!
Big congrats to @avonschulze for receiving an NIH F32 fellowship! Very well-deserved! Can't wait to see the outcome of his project testing fundamental mechanism of aging. @NIHAging @ScienceStowers