@HSCRB

Harvard Department of Stem Cell and Regenerative Biology. Header 📷 from the Melton lab: insulin-producing beta cells derived from stem cells

 Cambridge, Massachusetts
hscrb.harvard.edu
Joined February 2013
  • Tweets950
  • Following407
  • Followers3.7K
132Media
Thrilled to see our ExIGS tool featured! A true testament to the power of collaboration. Huge congrats to the team for their hard work! 🧬@ajaylabade31 @z_chiang @CarolineComenho nature.com/articles/d41586-0…
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Excited to share our newest paper out today in @ScienceMagazine!
Dawn Chen
@dawnchenx11 Oct 2024
Our paper on continuous mutagenesis in living cells using HACE is now out in @ScienceMagazine! We now demonstrate that HACE continuously generates mutations over a 10-day period and enables targeting using dCas9 without introducing DNA nicks. science.org/doi/10.1126/scie…

Helicase-assisted continuous editing for programmable mutagenesis of endogenous genomes

Deciphering the context-specific relationship between sequence and function is a major challenge in genomics. Existing tools for inducing locus-specific hypermutation and evolution in the native...

science.org
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Have you ever met a kid who doesn’t have a zillion questions about axolotls? I know I haven’t. That’s why I wrote this book! With super cute and accurate illustrations by @LordABethany @MacKidsBooks @neonsquidbooks us.macmillan.com/books/97816…

Axolotl (Young Zoologist)

An illustrated first guide to cute axolotls from expert Dr. Jessica LaMae Whited, featuring illustrations by Bethany Lord.You might know that axolotls are so...

us.macmillan.com
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7 years ago, I met a junior fellow named @JD_Buenrostro who blew me away with a vision of futuristic genomic technologies Today, we (@ajaylabade31, @carolinecomenho) are excited to share our first steps into that future: Expansion in situ genome sequencing 1/
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“Every cell is a special snowflake” retweet if you agree! #teamsnowflake nature.com/articles/d41586-0…
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Organoid culture promotes dedifferentiation of mouse myoblasts into stem cells capable of complete muscle regeneration go.nature.com/47lBikW
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Thank you to Alie Ward @Ologies for giving me the opportunity to talk about how we—and others—are using axolotls to understand how regeneration happens, and so much more! And thank you to her listeners for all the great questions 😊 alieward.com/ologies/ambysto…

Ambystomology (AXOLOTLS … AND LIMB REGROWTH?) with Dr. Jessica Whited — alie ward

Feathery gills! Adorable smiles! Cultural icons! Habitat ecology! And superhuman limb regeneration? It’s an entire episode on axolotls. You either love these aquatic salamanders, or you’ve never...

alieward.com
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Five questions with Ryan Flynn go.nature.com/4bRW1xx
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In a new @Nature paper from the @ArlottaLab, Drs. Noelia Antón-Bolaños (@BolanosAnton) and @IreneFaravelli created brain #chimeroids with cells from several people. 🧠 Read the article: go.nature.com/4cR8cvg Listen to the discussion: bit.ly/4bBpFH2
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Finally out @Nature! “Chimeroids” as powerful avatars of the human Brain can recapitulate unique features and responses of individual people. Congrats to our outstanding co-leads @BolanosAnton, @IreneFaravelli👩‍🔬👩‍🔬and all the team!🧫🧠 nature.com/articles/s41586-0…

Brain Chimeroids reveal individual susceptibility to neurotoxic triggers

Nature - An analysis in 3D multidonor Chimeroids—a scalable multidonor human brain organoid model—shows that human genetic background may be an important mediator of neurotoxin...

nature.com
Noelia Antón-Bolaños@BolanosAnton26 Jun 2024
📢Thrilled! My 1st piece of work of my postdoc at @Arlottalab is out @Nature! This has been a huge co-lead effort with @IreneFaravelli👩‍🔬👩‍🔬🤩 Link: nature.com/articles/s41586-0… Tweetorial 👇🧵
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📣 Check out our latest episode! Dr. Ryan Flynn (@raflynn5) from @BostonChildrens and @HSCRB talks about the discovery of #glycoRNAs. Listen now: bit.ly/3xCxRbL
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Don't miss next week's episode with Dr. Ryan Flynn (@raflynn5) from @BostonChildrens and @HSCRB! Check out his team's @BioRxivPreprint on #glycoRNA: bit.ly/3UbRiRt
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Thank you for such warm welcome! It was an honor to share my research on multidonor human cortical chimeroids from @Arlottalab and @broadinstitute at the SPiNES Seminar Series. Engaging with such a thoughtful and insightful audience was truly inspiring!
Neuroscience at NYU Langone Health@NYULH_Neuro4 Apr 2024
We're excited to welcome @BolanosAnton speak about her latest research using multidonor human cortical chimeroids from the @Arlottalab and @broadinstitute as part of our SPiNES Seminar Series! Big thanks to @holly_gildea and @ScienceLemon92 for hosting!
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Spatial intra-tumor heterogeneity is associated with survival of lung adenocarcinoma patients - check out the research by @HSCRB Franziska Michor, @MSKCancerCenter Robert J. Downey & colleagues in @CellGenomics #AACR24 hubs.li/Q02rxfLV0

Spatial intra-tumor heterogeneity is associated with survival of lung adenocarcinoma patients

Using three orthogonal spatially resolved molecular profiling technologies, Wu et al. identified two groups of lung adenocarcinomas with distinct patterns of geographic diversification. They found...

cell.com
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NYSCF – Robertson Stem Cell Investigator Alumna Paola Arlotta of @Harvard shares her vision for the future of #GenderEquity. See actionable strategies put together by NYSCF’s Initiative on Women in Science and Engineering group for supporting #WomeninSTEM: bit.ly/3VhgwPp
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Don't forget to listen to @RiboZonePodcast with Ryan Flynn (@raflynn5) as he talks #GlycoRNA, his time in the Bertozzi Lab (@CarolynBertozzi), and his new lab in Boston! open.spotify.com/episode/3aT…
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This year's Pradel Research Award winner Paola Arlotta of @HSCRB & @broadinstitute has provided key insights into the fundamental principles that guide development of the cerebral cortex. Read about her innovative work this #BrainAwarenessWeek: ow.ly/YjO350QRsXQ #NASaward
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Graduate Student Spotlight: Alan Baez Vazquez @A_Baez_Vazquez @RuthFranklinLab @NIH @HSCRB @HMS_Immunology @HarvardGSAS @HMS_Immunology @UMaine @jacksonlab mcb.harvard.edu/department/n…
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Our lab’s latest pre-print on how projection neurons regulate differential myelination in the cortex is out on bioRxiv today! Congrats to lead authors @VahbizJ @NuriaIturza @kwanho_k and many thanks to our awesome collaborators! biorxiv.org/content/10.1101/…

Neuronal-class specific molecular cues drive differential myelination in the neocortex

In the neocortex, oligodendrocytes produce distinct amounts of myelin in each cortical layer and along the axons of individual neuron types. Here we present a comprehensive single-cell molecular map...

biorxiv.org
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Thanks to everyone who retweeted! I’d love to hear from you if your interested in the opportunity. Lab info: buenrostrolab.com/research Neuro applicants: Email me and I’ll send you a list of collaborators/co-mentor labs

Research — Buenrostro Lab

buenrostrolab.com
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