Biochemist and cell biologist studying infectious diseases. Investigating drug resistance in malaria in the Spielmann lab.
Hamburg
Joined April 2018
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I have a stand-alone figure showing a certain additive does not improve treatment for one disease, eventhough it does for similar diseases. Any suggestions for where/how to publish it? #micropublication #onefigurepaper #preprint #response #lettertotheeditor Specific journals?
Very much enjoy talking about malaria all day at BioMalPar and listening to so many amazing things others have done
@jessi_K309 @jcubmar #EMBLMalaria
Time to introduce my latest paper.
TL;DR: I found potential functions for a quarter of the #malaria proteins that did not have a known function before, by analysing their #Alphafold structures. (1/7) nature.com/articles/s41598-0…
And what are HRP (heptatricorepeat) proteins? Known HRP proteins bind and process RNA in plastids, like mitochondria and apicoplasts. Many of them also have a RAP-domain which binds RNA. I hope future research will further investigate these knew potential HRP proteins. (7/7)
Combining both search approaches, I found similarities to known domains in 353 proteins (>25%) of unknown function. Did I find anything in your favourite protein? Check supplementary data 2+3. Or come find me at the #BioMalPar conference next week #EMBLMalaria (8/7)
My paper on using Alphafold2 to find domains in Plasmodium proteins came out today. So I opened twitter to tell you all about it and see @jankosinski posting about AlphaFold3 just being released. Who is not going to sleep tonight?
first things first, here is the paper nature.com/articles/s41598-0…
I'll present the results at BioMalPar in two weeks, so come find me there if you are a malaria person. Or just drop me a message if you want to talk about it
Can resistance of #malaria parasites to the main drug #artemisinin increase further? @HMBehrens and Sabine Schmidt from the Malaria Cell Biology group of Tobias Spielmann and @KCCR_GH & @BNITM_de have analysed numerous mutations, combinations of mutations and parasites (1/2)
after repeated drug-exposure. Interesting results: the higher the resistance the lower the fitness of the parasites. New paper in mBio:👉lnkd.in/eQxWqnjJ (2/2)
For world malaria day Anna interviewed Oumou and that makes me happy because I like working with both of them ☺️
Hannah Behrens retweeted
It's #WorldMalariaDay today: April 25! #Malaria researcher Anna Bachmann from @BNITM_de talked to her Ghanaian colleague Oumou Maiga-Ascofaré from @KCCR_GH about her motivation, role models and future challenges in malaria control. @AnnaBachmann11 @MaigaAscofare
Hannah Behrens retweeted
Today #infectneXt talks about #malaria. One of the pioneers for #malariaVaccine was the #biologist Ruth S. Nussenzweig (1928–2018), who discovered the key component of the recently endorsed vaccines: the circumsporozoite protein (CSP) of Plasmodium falciparum. #WomeninScience
I love giving Advanced Cell Bio lectures in Bremen. For private reasons I will not continue to do so. Are you interested in this lecturer position? Contact me if you have questions about it. You'd work with a bunch of exceptionally motivated students! shorturl.at/uGZ78
On my way back from the first Advanced Cell Bio lecture of the semester in Bremen. I'm looking forward to working with this interactive bunch of students
