The Stem Cell Research Institute @DKFZ HI-STEM (Heidelberg Institute for Stem Cell Technology and Experimental Medicine) gGmbH Head: Andreas Trumpp
Heidelberg, Germany
Joined November 2017
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HI-STEM - Cancer and Stem Cells in Heidelberg retweeted
Check out Georg Nagel – the 2026 medicine prize laureate – wearing a blue helmet and a big smile, cycling into the University of Würzburg to a warm welcome full of balloons and applause from students.
Check out his first reaction interview here: bit.ly/4yO0fBH
1/8 🧵 How do HER2+ breast cancers escape targeted therapies?
A groundbreaking paper in @CancerDiscovery led by Roberto Würth, Andreas Trumpp, and colleagues at @hi_stem_lab reveals a new route of treatment resistance: Neuroendocrine Differentiation (NED) 🧬👇
7/8 💡 Key Takeaways:
1️⃣ NED is a major driver of resistance to HER2 targeted therapy in breast cancer.
2️⃣ EpCAM-based CTC detection misses NED escapees — NCAM+markers are needed.
3️⃣ FGFR1 inhibition offers a potential strategy to target drug-resistant neuroendocrine-like cells
8/8 📖 Dive into the full paper in Cancer Discovery (2026):
🔗aacrjournals.org/cancerdisco…
Kudos to the entire research team for this major breakthrough! 👏 #BreastCancer #Oncology #CancerResearch #TherapyResistance #Biotech
1/8 🧵 Rethinking Hematopoietic Stem Cell Isolation: Is CD150 missing a vital piece of the puzzle?
A ground-breaking new study in @CellStemCell from @DawnSLin, Andreas Trumpp, and colleagues at @hi_stem_lab reveals a previously unrecognized, deeply dormant HSC population!🩸👇
7/8 🧠 Why It Matters
Understanding HSC heterogeneity and deep dormancy is vital for improving stem cell therapies,bone marrow transplantation, and targeting leukemic stem cell niches that evade traditional treatments.
8/8 📖 Read the full open paper in Cell Stem Cell: sciencedirect.com/science/ar…
Congrats to all the authors! 👏 #StemCells #Hematology #Immunology #ScienceTwitter
HI-STEM - Cancer and Stem Cells in Heidelberg retweeted
Congratulations to our researchers on receiving the @BCD_AACR Blood Cancer Discovery Award for Outstanding Journal Article🎉! Learn how their single-cell atlas of healthy and AML blood cells paves the way for patient classification & precision medicine.
aacrjournals.org/bloodcancer…
HI-STEM - Cancer and Stem Cells in Heidelberg retweeted
Researchers are uncovering a complex dialogue between tumor cells and nerves that may help drive the growth and spread of pancreatic cancer. Learn more about this research, which was presented at #AACRpan26, on the #AACRBlog: brnw.ch/21x6HXe @hi_stem_lab @umichmedicine
HI-STEM - Cancer and Stem Cells in Heidelberg retweeted
Striking a Nerve in #PancreaticCancer: Unraveling the Crosstalk Between Tumor Cells and Neurons
aacr.org/blog/2026/10/23/str…
