@HBarsouk

PhD student | Gao Lab @StanfordBiochem | Hertz Fellow | previously @yaleMBB ‘25

 Pittsburgh, PA
Joined September 2022
  • Tweets169
  • Following205
  • Followers95
29Media
TA game going hard 😭😭
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Hannah Barsouk retweeted
Steve L. Bonilla@Steve_BonillaOct 14
Check the preprint of our exciting collaboration with @PilarCossio2 and others: Quantifying RNA Folding Equilibria from Unclassfied Cryo-EM Images biorxiv.org/content/10.64898… see Pilar's very nice description. Congrats Deb Maji and team!

Quantifying RNA Folding Equilibria from Unclassified Cryo-EM Particle Images

Functional RNA structures are typically far more dynamic than most proteins solved by cryo-electron microscopy (cryo-EM). Flexible junctions and weak tertiary contacts produce broad conformational...

biorxiv.org
Pilar Cossio@PilarCossio2Oct 14
1/5 Cryo-EM gives high-resolution RNA structures, but only when high Mg²⁺ freezes out their motion. At physiological conditions, RNAs are dynamic and 3D reconstruction fails. Can we still learn their folding equilibria? New preprint: yes, straight from the raw particle images👇
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Hannah Barsouk retweeted
The Nobel Prize
@NobelPrizeOct 5
BREAKING NEWS The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
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Hannah Barsouk retweeted
Quanta Magazine
@QuantaMagazineSep 27
We are in no small part made of virus. Over millions of years, our DNA has accumulated so many viral snippets that they now make up 8% of our total genome. quantamagazine.org/how-virus…

How Virus-like ‘Jumping Genes’ Became Our Partners in Evolution | Quanta Magazine

Half of our genome is made of transposons — snips of DNA that can move and copy themselves. But they’re more than parasites or genetic junk.

quantamagazine.org
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Hannah Barsouk retweeted
nature
@NatureSep 27
An AI revolution is sweeping through education. But teachers who can convey the excitement of thinking and learning are irreplaceable go.nature.com/3VbVDHw

In praise of human teachers: universities must resist outsourcing everything to AI

Nature - An AI revolution is sweeping through education. But teachers who can convey the excitement of thinking and learning are irreplaceable.

nature.com
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Hannah Barsouk retweeted
Gao Lab@GaoLab_Sep 23
Hannah and Simone co-taught a crash course on cryoEM to the 1st year Stanford medical students !
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Yunha Hwang
@Micro_YunhaSep 15
Microbial genomes have been extensively mined for new proteins, but the noncoding sequences between genes remain largely unexplored despite encoding important regulatory and functional information. In our new work, we asked whether gLM2 could help systematically discover these intergenic features. tatta.bio/intergenic-sae
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Stanford Medicine
@StanfordMedSep 9
Congratulations to Stanford Medicine sleep researcher, Emmanuel Mignot, MD, PhD, on receiving this year’s Albert Lasker Basic Medical Research Award, one of the most prestigious science prizes in the world. He discovered that narcolepsy stems from a deficiency of orexin in the brain, opening the door to new sleep therapies. stan.md/4xGWHkT #LaskerAward
Congratulations to Stanford Medicine sleep researcher, Emmanuel Mignot, MD, PhD, on receiving this year’s Albert Lasker Basic Medical Research Award, one of the most prestigious science prizes in the world

ALT Congratulations to Stanford Medicine sleep researcher, Emmanuel Mignot, MD, PhD, on receiving this year’s Albert Lasker Basic Medical Research Award, one of the most prestigious science prizes in the world

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Last call! 📣 Join us tonight at 6:00 PM ET to talk with Hertz Fellows about the application and interview process. Meet tonight’s speakers and get your login here — if you haven’t already: bit.ly/Info-Sept10 Bring your questions and hear directly from our Fellows about what makes a strong candidate, applying without published research, navigating a gap year, preparing for interviews, and more. Can’t make it tonight? Join us Monday, Sept. 14 at noon ET for our next application info session. Register here: bit.ly/Sept14-Info #HertzFellows #2027HertzFellowship #Fellowship #GraduateStudents
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Hannah Barsouk retweeted
Niko McCarty.
@NikoMcCartyAug 19
More atomic force microscopy videos. These show Cas9 "searching" through DNA and then cutting it. It's surprising how long the DNA cut takes. It'd be cool to see similar videos for bridge recombinases. These were published by the great @hnisimasu in 2017.
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Giant viruses are so cool 🤩
Science Magazine
@ScienceMagazineAug 18
The virus PelV-1 has a tail of unprecedented length. Learn more: scim.ag/4cviwvb #ScienceMagArchives
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Michael Baym@baymAug 6
This is a wild overstatement of what was actually achieved. But “AI successfully remixed a small number of mostly already-observed, largely synonymous mutations and in a few rare cases managed to make it nonlethal” doesn’t sell hype as well
Polymarket
@PolymarketAug 6
JUST IN: Scientists warn of “urgent” biosecurity concerns after AI successfully designs 16 new viruses capable of replicating inside cells.
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Hannah Barsouk retweeted
Quanta Magazine
@QuantaMagazineAug 5
The muon is a heavier cousin of the electron. Every particle in existence has some small effect on its movement. By measuring exactly how the muon “wobbles,” physicists might be able to infer the presence of as-yet undiscovered particles. quantamagazine.org/physicist…

Physicists Solve a Muon Mystery. Now, Old Results Don’t Add Up. | Quanta Magazine

New calculations seem to have put a 25-year-old particle physics puzzle to rest. But they’ve also created a clash with other experimental results.

quantamagazine.org
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Gao Lab@GaoLab_Aug 4
Congratulations to Simone (@simone_alma), Collin, and Max (@maxewilkinson) on their paper - out today- on terminase sensing by Avs2 and Upx! (1/4) nature.com/articles/s41467-0…

Phage terminase recognition by the bacterial immune sensors Avs2 and Upx

Nature Communications - Direct recognition of viral proteins is key to bacterial immunity. Here, Evans et al. uncover the mechanisms used by two distinct defense proteins to detect the phage DNA...

nature.com
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Hannah Barsouk retweeted
Tominaga K. (tomiken)@pacyc1841Aug 3
The Origins and Evolution of the RNA Virome in Land Flora: Molecular Plant cell.com/molecular-plant/abs…

The origins and evolution of the RNA virome in land flora

By mining transcriptomes and genomes across 2402 species, this study discovers ∼35 000 plant-associated RNA viruses, substantially expanding the known plant virosphere. Phylogenomic analyses reveal...

cell.com
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Hannah Barsouk retweeted
Quanta Magazine
@QuantaMagazineAug 3
None of RNA’s remarkably versatile forms are built to last — not even within the cell that they came from. quantamagazine.org/cells-acr…
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Hannah Barsouk retweeted
ShorterLab@ShorterLabJul 30
Quantifying protein unfolding kinetics with a high-throughput microfluidic platform: Cell Systems cell.com/cell-systems/fullte…

Quantifying protein unfolding kinetics with a high-throughput microfluidic platform

Atsavapranee et al. present a microfluidic platform that accurately quantifies unfolding kinetics for many proteins in parallel. After expressing and immobilizing EGFP-tagged variants within device...

cell.com
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Hannah Barsouk retweeted
Sofia Luengo-Woods@sluengowoodsJul 29
We’re so excited to share our new paper, where we tackle the wealth of structural and functional diversity of anti-phage sensors across bacteria (1/6)
nature
@NatureJul 29
Nature research paper: Diverse bacterial pattern recognition receptors sense the core phage proteome go.nature.com/4w2kf25

Diverse bacterial pattern recognition receptors sense the core phage proteome

Nature - Systematic analysis of prokaryotic STAND NTPases — relatives of animal and plant immune receptors — uncovers diverse antiviral sensors that detect most of the core structural...

nature.com
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Congrats Sofia, Hyunbin, and everyone in the lab on their paper on bacterial sensing of the phage proteome!!
nature
@NatureJul 29
Nature research paper: Diverse bacterial pattern recognition receptors sense the core phage proteome go.nature.com/4w2kf25

Diverse bacterial pattern recognition receptors sense the core phage proteome

Nature - Systematic analysis of prokaryotic STAND NTPases — relatives of animal and plant immune receptors — uncovers diverse antiviral sensors that detect most of the core structural...

nature.com
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Hannah Barsouk retweeted
hnisimasu@hnisimasuJul 28
Happy to announce our paper on the DRT3 anti‑phage defense system has been published in Cell! Many thanks to @SternbergLab and @shsternberg for the fantastic collaboration! cell.com/cell/fulltext/S0092…
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