@GuptaPenn

Research Associate Professor of Biochemistry and Biophysics | Univ of PA | he/him Find me at @guptapenn.bsky.social

 Philadelphia, PA
med.upenn.edu/gupta-lab/
Joined February 2019
  • Tweets1.3K
  • Following4.5K
  • Followers1.6K
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Saint Joseph's Athletics mourns the passing of Chris DiJulia. A fixture on the Saint Joseph's sidelines over three decades, DiJulia was on the Hawks' women's basketball bench for many of the program's biggest moments. Invited by then-head coach Jim Foster to sit on the Saint Joseph's bench, DiJulia was a part of three Atlantic 10 championships, more than a dozen Big 5 titles and over 20 postseason appearances. Born with cerebral palsy, DiJulia was recognized for his infectious spirit in 2001-02 with the creation of the Chris DiJulia Inspirational Award by the women's basketball program. The son of longtime athletic director Don DiJulia, Chris was inducted into the Saint Joseph's University Women's Basketball Hall of Fame in the spring of 2018. ✍️ sjuhawks.com/news/2026/7/28/…
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Kushol Gupta retweeted
Mike Mitchell@MJMitchell_LabJun 2
Excited to share @MJMitchell_Lab superstar PhD student @HannahGeisler_'s thesis defense titled “Engineering targeted lipid nanoparticles for nucleic acid delivery to the placenta” is June 3rd at 3PM ET! Location: Glandt Forum, @UPennSinghNano Zoom: upenn.zoom.us/j/2815911137
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So excited to join the @BWFUND family and the amazing scientists who continue to push our understanding of host pathogen interactions forward! Thanks to all the mentors who have supported me!
BWFUND@BWFUNDMay 19
BWF Announces the 2026 Investigators in the Pathogenesis of Infectious Disease bwfund.org/news/bwf-announce… #bwfpath
The Burroughs Wellcome Fund is pleased to announce the recipients of the 2026 Investigators in the Pathogenesis of Infectious Disease (PATH) awards, recognizing assistant professor-level scientists whose research is advancing understanding of infectious disease mechanisms and informing new approaches to prevention, diagnosis, and treatment.

ALT The Burroughs Wellcome Fund is pleased to announce the recipients of the 2026 Investigators in the Pathogenesis of Infectious Disease (PATH) awards, recognizing assistant professor-level scientists whose research is advancing understanding of infectious disease mechanisms and informing new approaches to prevention, diagnosis, and treatment.

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Kushol Gupta retweeted
Mike Mitchell@MJMitchell_LabMar 15
If you're in the Bay Area come check out @MJMitchell_Lab Postdoctoral Fellow Marshall Padilla's seminar this Monday at 11am @Stanford @Stanford_ChEMH on his work in @NatureBiotech @NatureComms on new mRNA LNP platforms + solution-based biophysics! Link: chemh.stanford.edu/events/sa…
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Nanoparticle blueprints reveal path to smarter medicines | Penn Today - Hannah Yamagata, Research Assistant Professor Kushol Gupta and postdoctoral fellow Marshall Padilla, holding 3D. (From left) Doctoral student ... - ift.tt/ykgN4LO

Nanoparticle blueprints reveal path to smarter medicines | Penn Today

New research involving Penn Engineering shows detailed variation in lipid nanoparticle size, shape, and internal structure, and finds that such factors correlate with how well they deliver therapeu...

penntoday.upenn.edu
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Kushol Gupta retweeted
Wei Tao@WeiTaoLab30 Oct 2025
This integrative approach represents a notable advance in LNP characterization, offering a more mechanistic understanding of how structural and biophysical attributes influence functional performance. - Another fantastic work by @MJMitchell_Lab and his team! @NatureBiotech
Nature Biotechnology
@NatureBiotech29 Oct 2025
Replying to @NatureBiotech
Research Briefing: Solution biophysics reveals the polydisperse structure of RNA lipid nanoparticles go.nature.com/47Mquhs rdcu.be/eNlNL
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Check out our latest research briefing in @NatureBiotech led by @MJMitchell_Lab Postdoc Marshall Padilla showing how solution biophysics can reveal the polydisperse structure of RNA lipid nanoparticles! Briefing: nature.com/articles/s41587-0… Original Article: nature.com/articles/s41587-0…
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Using X-rays at @CHESS_user, Dr. Kushol Gupta @GuptaPenn and @PennMedicine scientists found that DNA’s building blocks can unfold under high pressure and spring back when pressure eases, offering new clues into genome stability and disease. Read more: bit.ly/48TkDbo
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Elucidating lipid nanoparticle properties and structure through biophysical analyses go.nature.com/4oTt639
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Thrilled to share our latest in @NatureBiotech led by @MJMitchell_Lab Postdoc Marshall Padilla in collaboration w @GuptaPenn on elucidating mRNA lipid nanoparticle structure through biophysical analyses! LNPs can have crazy shapes, see below: Free access: rdcu.be/eMmd0
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I'm really grateful for this write-up from Cornell High Energy Synchrotron Source (CHESS) on our recent work! Under Pressure: How CHESS Helped Reveal Hidden Differences in Our DNA Packaging chess.cornell.edu/under-pres…
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Kushol Gupta: Introduction to the SAMPREP special issue #SamplePreparation #StructuralBiology #CryoEM @Penn... #IUCr journals.iucr.org/paper?S205…
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📢 Don't miss the #Juneteenth Special Issue from #ACSBioMedAu led by @BookerMan_PSU! It features the outstanding research of current black scientists, the diversity of their work, and how they are advancing this field of science. Read for free: go.acs.org/cW4
Graphic design with the text: 'Special Issue. . ACS Bio&Med Chem. . Open Access. . Juneteenth. . Read for free'

ALT Graphic design with the text: 'Special Issue. . ACS Bio&Med Chem. . Open Access. . Juneteenth. . Read for free'

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Chris's @TheBourneImmuno paper is online now. Huge thanks to @BookerMan_PSU for coordinating this special Juneteenth issue @ACSPublications ACS Bio & Med Chem Au. Congrats to our growing lab and all who contributed. Happy 4th everyone!! pubs.acs.org/doi/full/10.102…
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New cryo-EM structures shine light on key steps in CRISPR-based adaptive immunity! Viral DNA induces a structural change in the Cas1-2/3 integrase needed for recruitment to the CRISPR. We capture how CRISPR repeat is unwound to allow complete integration! biorxiv.org/content/10.1101/…
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WE ARE HIRING: Postdoc Positions! Join us at UPenn in vibrant Philly, cutting-edge science, great city, amazing team. Please share and let's get in touch!
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Kushol Gupta retweeted
Paul Offit
@DrPaulOffit13 Jun 2025
My response to Secretary Kennedy's statements about me on Fox News today. It's time to set the record straight.
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haven't posted in a while but happy to share the news I've received the Beckman Young Investigator award 🥳 grateful for the hard work of my team pushing the barriers of understanding #Rloop biology and for this recognition🧬
Beckman Foundation@BeckmanFnd11 Jun 2025
Meet Charles Bou-Nader, PhD, 2025 Beckman Young Investigator Awardee from @emorymedicine! Read more about this news from Beckman Foundation: ow.ly/Bc7Y50W85bS #BYI
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The Advisory Committee on Immunization Practices (ACIP) has protected generations of Americans. Now, its credibility is being attacked: bit.ly/3HDSiKp
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Today's decision is about undermining independent medical expertise and will only further endanger the health of the American public, especially children. bit.ly/43Bwd80
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