@GuotingZhang

Assistant Professor@Fudan; Postdoc@EPFL；Postdoc@Stanford

 Vaud, Switzerland
Joined September 2020
  • Tweets25
  • Following155
  • Followers110
🚨 Our first Science paper 🚨 We report the isolation and reactivity of the first “inaccessible” 5-membered heteroaryne! 120+ year challenge! Congrats @jennahumke @belli_roman @ErinPlasek @Sal_K_3 @annabelly24 @CortnieRoberts @UMNChemistry @ScienceMagazine science.org/doi/10.1126/scie…

Nickel binding enables isolation and reactivity of previously inaccessible 7-aza-2,3-indolynes

N-Heteroaromatics are key elements of pharmaceuticals, agrochemicals, and materials. N-Heteroarynes provide a scaffold to build these essential molecules but are underused because five-membered...

science.org
23
81
15
519
68,580
17 years in the making.. We are super excited to finally achieve alcohol-alcohol cross-coupling enabled by the powerful SH2 radical sorting! Great work Jerry, Nick, Jay, James, Colin and Robert. Big shout out to our collaborator Jesus from Janssen Spain. science.org/doi/full/10.1126…
15
116
19
802
68,431
Thrilled to share that our paper on 1,3,2-diazaphospholene-catalyzed asymmetric Claisen rearrangement is now online in @ScienceMagazine . Check out the big step forward in DAP catalysis. science.org/doi/10.1126/scie…

Catalytic enantioselective reductive Eschenmoser-Claisen rearrangements

A phosphorus-based catalyst produces quaternary carbon stereocenters with high enantioselectivity.

science.org
9
27
2
127
15,119
Asymmetric #Synthesis of Cyclopamine, a Hedgehog (Hh) Signaling Pathway Inhibitor by Hao Shao, Wenheng Liu, Muhan Liu, Haibing He, Qi-Lin Zhou, Shou-Fei Zhu, and Shuanhu Gao in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
23
2
93
14,580
Guoting Zhang retweeted
Baran Lab
@BaranLabReads23 Aug 2023
CYCLOPAMINE! A total synthesis with LEO Pharma collaborators. Appearing today in @ChemRxiv : chemrxiv.org/engage/chemrxiv…
5
34
6
224
63,655
Divergent #TotalSyntheses of Illicium Sesquiterpenes through Late-Stage Skeletal Reorganization by Pengfei Fu, Tao Liu, Yang Shen, Xin Lei, Tianjie Xiao, Peng Chen, Dongsheng Qiu, Zhen Wang, and @YandongZhang16 at Xiamen University in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
24
108
18,958
❇️ In this Synfact of the month Martin Oestreich (@Silicon_Martin) highlighted the ´An Electroreductive Approach to Nickel-Catalyzed Enantioselective Cross-Coupling of Aryl Aziridines` by Nevado C. and co-workers from @UZH_en.😀 👉 fal.cn/3A0l3
1
6
19
4,003
Funny chemistry. pubs.acs.org/doi/10.1021/acs…

Enantioselective Bioreduction of Medicinally Relevant Nitrogen-Heteroaromatic Ketones

Abstract. We herein report an enantioselective bioreduction of ketones that bear the most frequently used nitrogen-heteroaromatics in FDA-approved drugs. T

pubs.acs.org
1
5
208
Guoting Zhang retweeted
Hanfeng Ding@HanfengD25 May 2023
Our third total synthesis work this year is now out in @J_A_C_S. Congrats to all the team members!
Total Synthesis@TotalSynthesis24 May 2023
#TotalSynthesis of (−)-Retigeranic Acid A: A Reductive Skeletal Rearrangement Strategy by Dongyu Sun, Ruyi Chen, Dongmin Tang, Qidong Xia, Yifan Zhao, Chun-Hui Liu, and Hanfeng Ding @HanfengD at @ZJU_China in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
6
10
159
32,976
Guoting Zhang retweeted
J. Am. Chem. Soc.@J_A_C_S12 May 2023
Total Synthesis of (±)- and (−)-Daphnillonin B @CHNSci @TotalSynthesis @TotalSyntheses #Totalsynthesis #NaturalProducts #PausonKhand #Metathesis #WagnerMeerwein #Rearrangement pubs.acs.org/doi/10.1021/jac…

Total Synthesis of (±)- and (−)-Daphnillonin B

Abstract. The first total synthesis of (±)- and (−)-daphnillonin B, a daphni­cyclidin-type alkaloid with a new [7-6-5-7-5-5] A/B/C/D/E/F hexa­cyclic core,

pubs.acs.org
18
1
99
16,888
#TotalSynthesis of Diverse Tetramic Acid Bearing cis-Decalin Natural Products (Xiaoguang Lei and co-workers) @PKU1898 onlinelibrary.wiley.com/doi/…
3
1
10
5,295
Base-Promoted Electrochemical CoII-catalyzed Enantioselective C-H Oxygenation (Bing-Feng Shi and co-workers) #AngewandteVIP onlinelibrary.wiley.com/doi/…
1
27
8,104
Guoting Zhang retweeted
Julien Vantourout@Julien075 Apr 2023
Tired of buying Ni(COD)2? Now you can quickly electrogenerate it using an ElectraSyn 2.0! A fruitful collaboration with @EngleLab, @BaranLabReads and BMS brilliantly conducted by @CamZRub that appeared today @ChemRxiv. chemrxiv.org/engage/chemrxiv…
7
45
8
277
58,594
Guoting Zhang retweeted
Baran Lab
@BaranLabReads27 Mar 2023
1
3
11
5,748
Reductive Asymmetric Aza-Mislow-Evans Rearrangement by 1,3,2-Diazaphospholene Catalysis (Cramer) @GuotingZhang @EPFL_CHEM #openaccess onlinelibrary.wiley.com/doi/…
1
5
1
23
6,124
Guoting Zhang retweeted
J. Am. Chem. Soc.@J_A_C_S8 Mar 2023
Ni-Cat Enantioselective Electrochemical Cross-Coupling: Aryl Aziridines & Alkenyl Bromides @NevadoLab @UZH_Science @UZH_Chemistry @TotalSyntheses #Ni #Catalysis #Enantioselective #Electrochemistry #Reuctive #CrossCoupling #Aziridine #Alkenylbromide pubs.acs.org/doi/10.1021/jac…

Nickel-Catalyzed Enantioselective Electrochemical Reductive Cross-Coupling of Aryl Aziridines with...

Abstract. An electrochemically driven nickel-catalyzed enantioselective reductive cross-coupling of aryl aziridines with alkenyl bromides has been develope

pubs.acs.org
1
19
2
91
15,968
Excited to see our latest work in the area of DAP catalysis now available on @angew_chem ! Reductive Asymmetric Aza‐Mislow‐Evans Rearrangement by 1,3,2‐Diazaphospholene Catalysis onlinelibrary.wiley.com/doi/…

Reductive Asymmetric Aza‐Mislow‐Evans Rearrangement by 1,3,2‐Diazaphospholene Catalysis **

A 1,3,2-diazaphospholene-catalyzed three-step cascade transformation of chiral N-sulfinyl acrylamides comprised of a conjugate reduction, enantiospecific [2,3]-sigmatropic aza-Mislow-Evans rearrang...

onlinelibrary.wiley.com
5
1,007
Congratulations to @jordiduran6 for a titanic effort! His first PhD work is out in @ChemRxiv, focusing on the Catalytic Asymmetric Defluorinative construction of alpha-Allyl Ketones. Kudos also to @javiml_94 @UniBarcelona @QuimicaUB Check it out here 👉 bit.ly/3RIlAIR
3
19
3
125
23,510
Guoting Zhang retweeted
Elva Hu@elvahupin20 Jan 2023
Two Terpenoid Derivatives with Different 3/5/6/6/5-Fused Pentacyclic Skeletons from Hedyosmum orientale @Wiley_Chemistry @wileyinresearch @WileyEngineer @wileyeng @isciverse @Innov_Materials @InnovationChem @CHNSci @NatProducts doi.org/10.1002/cjoc.2022005…
2
14
1
74
10,461
#NHCs #NHeterocyclicCarbenes Trost group reported new #bifunctional ligands bearing #chiral #NHC & #prolinol. Application in #Zn-#Cu catalyzed asymmetric #allylic alkylation. Simultaneous #coordination of two different metals! @pengcheng_gao @ChemEurJ doi.org/10.1002/chem.2021042…
NHCs_NHeterocyclicCarbenes_chiral_NHC_prolinol_bifunctional_chiral_catalysts_Trost_CEJ_2021

ALT NHCs_NHeterocyclicCarbenes_chiral_NHC_prolinol_bifunctional_chiral_catalysts_Trost_CEJ_2021

5
19
Load more