@GrubbLab

Our lab is interested in brain development, especially those processes of neuronal maturation which are shaped by electrical activity.

 London, England
grubblab.org/
Joined April 2018
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  • Following757
  • Followers1.6K
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When axons regrow after injury, how do they get their presynaptic terminals working again? Answer is: really quickly! Out now from us in @CellReports, led by the structure-function DreamTeam that is @LorcanBrowne & @ACrespoVieira ⤵️ cell.com/cell-reports/fullte… (1/6)
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📣ALBA & @ELSneuroscience invite you to nominate a neuroscientist who works in a country underrepresented among neuroscience publications/conferences, and is actively committed to DEI work in the field. Winner gives a talk at #FENS2024! 👉🏽 loom.ly/FEG7E-w 🗓️ 20 Oct 2023
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Very excited to announce that the lab has a website! dkneurolab.com/ Check it out for information about the type of work we plan to do and the type of lab we plan to be. @dev_neuro @dkneurolab

dkNeuroLab

**PRINCIPAL INVESTIGATOR**

dkneurolab.com
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The Brave Little Neuron was formed by a group of friends who wanted to share their scientific #research and make #neuroscience accessible for everyone. Look out for their workshop @EinsteinsGarden @GreenManFest on Friday. @MRC_CNDD @KingsIoPPN @pheereynolds #BraveLittleNeuron
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I'm thrilled to share our preprint from the Fleischmann lab! We find molecular signatures of ancestral cortical neurons in the mammalian olfactory cortex. @AlonsoOrGu @spinar_d @davidhbrann @Lab_Tali_Kimchi @Datta_Lab @matosches @CarneyInstitute biorxiv.org/content/10.1101/…

Mammalian olfactory cortex neurons retain molecular signatures of ancestral cell types

The cerebral cortex diversified extensively during vertebrate evolution. Intriguingly, the three-layered mammalian olfactory cortex resembles the cortical cytoarchitecture of non-mammals yet evolved...

biorxiv.org
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Keep an eye out for @pheereynolds @fmferreira_ @JuchaMoore, me and more in @EinsteinsGarden! #BraveLittleNeuron #SciComm
CDN | King's College@dev_neuro
10 Aug 2023
In one week our Brave Little Neuron team will be heading to @GreenManFest! They are all completing PhDs @dev_neuro @CNDD @KingsIoPPN @KingsCollegeLon in topics including visual system, foetal brain development, schizophrenia and depression.   @EinsteinsGarden #BraveLittleNeuron
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Yes! This is going to be a fantastic adventure, with @NeuroBender and @neuronJoy along for the ride too!
Аnа Dorrego Rivas@adorrego_r
9 Aug 2023
Had to read the email 4 times at least…but it’s official! I’ve just got a Wellcome Trust Early Career Award to work on axodendritic interactions during development, a dream coming true! That also means that @GrubbLab and I will be working together for a looooong time 😁
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Amazing job! And all achieved in the face of sustained PI laboratory 'assistance'...
Аnа Dorrego Rivas@adorrego_r
27 Jul 2023
Amazing first week of our @in2scienceUK students: first experiment, first successful staining!
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Great paper, yet another proof that the fixation you use for your staining can make a huge difference: just look at figures 2 and 7! science.org/doi/full/10.1126…

Glyoxal fixation: An approach to solve immunohistochemical problem in neuroscience research

Glyoxal enhances antibody penetration and antigenicity in neural tissues, making any antigen-exposing techniques unnecessary.

science.org
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Fantastic 'Impaired Airs' meeting @KingsCollegeLon today, superbly organised and chaired by @rowanrobo as part of the @AnosmiaHistory project. Thanks to all who participated, including @SAHowardSmith, @WillTullett, @chriskelly151 and many talented others - I learnt so much!
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A #NewPI, will I ever be able to recruit an overseas postdoc? First BREXIT, then visa fees going even more insane! 99.9% of the people in my sub-field do not have a British passport!
Martin Smith@martinrsmith
14 Jul 2023
The UK is planning on massively increasing visa costs. Currently a researcher looking at a 5-year Global Talent Visa, together with their partner and two children, needs to find £13.4k. All up front. A big ask. But that’s now slated to increase to… **£20.9k**
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The efforts and cost required for a lab member to get a visa to visit collaborators in the UK has been crazy. And it is also supremely humiliating for the applicant. Good luck with remaining competitive with such conditions.
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#FluorescenceFriday courtesy of our work experience student Lily Burke! Stunning dopaminergic neurons and NGF in the olfactory bulb
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As an academic writing coach, here are the 7 mistakes I see supervisors and PIs make in the process of co-writing a paper with their PhD students or mentees. A thread. 🧵 #AcademicTwitter #PIchat #newPI
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📣Fully funded postdoc position available in my lab @dev_neuro at King’s College London! This is a very exciting project focused on the development and regenerative potential of human choroid plexus using organoids!🧠 (Please RT🙏) Apply here: kcl.ac.uk/jobs/070685-postdo…
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Just getting started in #patchclamp #electrophysiology? Then our latest #Neurowire article '10 common patching problems and how to fix them - a guide for beginners' by @emily_winson, @GrubbLab will help! buff.ly/3Cq0dFl
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Synaptic elimination is essential for neural development. Our new study in mitral cells explains how neurons prune all but one type of synaptic input through synaptic competition. Open access in @Dev_Cell cell.com/developmental-cell/… (1/7)

Activity-dependent local protection and lateral inhibition control synaptic competition in develo...

Fujimoto, Leiwe, Aihara, et al. show that strong glutamatergic inputs to a dendrite trigger local protection and lateral inhibition via NMDARs and RhoA, leading to the pruning of all but just one...

cell.com
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🔥 new position open now!
Dimitri Kullmann@Newrotrash
30 May 2023
Come work with @LignaniLab_UCL @s_schorge and the rest of us on gene therapy for epilepsy rb.gy/wxya8
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So finally my first ever (!!!) first author is out into the world of BioRxiv summarising my PhD work - Synaptic alterations associated with disrupted sensory encoding in a mouse model of tauopathy. Twitter 🧵 below biorxiv.org/content/10.1101/…

Synaptic alterations associated with disrupted sensory encoding in a mouse model of tauopathy

Synapse loss is currently the best biological correlate of cognitive decline in Alzheimer’s disease and other tauopathies. Synapses seem to be highly vulnerable to tau-mediated disruption in neurod...

biorxiv.org
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One feels so small at the Greenwood Theatre! Nice venue for the @KingsCollegeLon School of Neuroscience Symposium, excellent talks and questions!
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Importin 13-dependent Axon Diameter Growth Regulates Conduction Speeds along Myelinated CNS Axons biorxiv.org/cgi/content/shor… #biorxiv_neursci
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