@GriffithFlyLab

Leslie Griffith’s Lab, Brandeis University, Neuroscience.

 Waltham, MA
griffithlabbrandeis.com
Joined May 2020
  • Tweets77
  • Following131
  • Followers232
5Media
Congratulations to @Neuro_Mohamed on defending your thesis and your last day in the Griffith Lab! We are so proud of all you've accomplished and you will be missed greatly!
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A new paper from our lab is out!
Brandeis Neuroscience@BrandeisNeuro20 Dec 2022
Subtype-specific roles of ellipsoid body ring neurons in sleep regulation in Drosophila @GriffithFlyLab jneurosci.org/content/early/…
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Leslie from Brandeis Ugly Sweater Contest 2022 ... We should have won! 🤣
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Real Houseflies of Brandeis retweeted
Krishna Melnattur@melnattur26 Oct 2022
Been working with flies for a long time, didn’t think I would be surprised by anything flies did. But, wow..
Lisa Fenk@lisafenk26 Oct 2022
Paper out!!! #Drosophila has muscles that attach to their retinas, which it uses to move its photoreceptor sheet in ways that resemble vertebrate eye movements @Nature nature.com/articles/s41586-0…
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Katya Morozova@neurochart31 Aug 2022
New review paper from the @MarderLab! Latest insights from small rhythmic neural circuits on individual variability, resilience and neuromodulation of neurons and neural networks. sciencedirect.com/science/ar…
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Check out our latest work by Michael Hobin et al. !!!
Brandeis Life Sci@BrandeisLS30 Aug 2022
microRNA regulation of sleep in the fruit fly @GriffithFlyLab @Neuro_Mohamed @EmaCiencia @urccbrandeis @BrandeisNeuro @BrandeisScience
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Paul Garrity@Nemvec18 Aug 2022
Our lab @Brandeis (~Boston) now hiring a Research Tech. We study how flies/mosquitoes sense the world using molbio/genetics. Whether goal is PhD/MD program in ≥2 yrs (recent ex-techs in PhD (UC Berk.,UVM), MD/PhD (BU) programs) or long-term, contact us. brandeis.wd5.myworkdayjobs.c…
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Scott Waddell@ScottishWaddell18 Jul 2022
How does multisensory learning improve memory performance, for even the individual sensory cues? Zeynep Okray @z_okray, Pedro Jacob, Ciara Stern, Kieran Desmond, @_Nils_Otto_ and @paovargtz show how. biorxiv.org/content/10.1101/…

Multisensory learning binds modality-specific neurons into a cross-modal memory engram

Associating multiple sensory cues with objects and experience is a fundamental brain process that improves object recognition and memory performance. However, neural mechanisms that bind sensory...

biorxiv.org
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The Katz lab in Brandeis University is looking for postdocs, see the ad for more details. P.S. we are looking for postdocs as well!
Katz Lab@BlechLab30 Jun 2022
The Katz Lab is looking for postdoctoral researchers! katzlab.squarespace.com/ Please RT or share with anyone who might be interested
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SfN Journals@SfNJournals16 Jun 2022
#JNeurosci: @Neuro_Mohamed et al. @BrandeisU developed a method to study memory formation in excised brains from Drosophila melanogaster. This method can reproduce the salient features of memory formation that have been identified in intact animals. jneurosci.org/lookup/DOI/10.…
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Piali Sengupta@SenguptaLab14 Jun 2022
Lab's latest pub🍾!! Inversion of the response sign in a single olfactory neuron reverses olfactory preference behavior! Unexpected - we thought it was an artifact for the longest time. Congrats to all authors and esp Munzareen Khan for seeing this through! Preprint tweetorial 👇🏽
PLOS Biology@PLOSBiology14 Jun 2022
Context modulates valence of individual odorants in #Celegans: context-dependent engagement of distinct signaling pathways within a single sensory neuron type can switch #olfactory preference #behavior from attraction to aversion @SenguptaLab #PLOSBiology plos.io/3zBEfPl
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The final version of @Neuro_Mohamed’s paper is officially out. In an ex vivo model of Drosophila associative memory, pairing activation of the CS pathway with activation of the US pathway forms a pairing-dependent plasticity (PDP). (1/5) jneurosci.org/content/42/21/…

Pairing-Dependent Plasticity in a Dissected Fly Brain Is Input-Specific and Requires Synaptic...

In Drosophila , in vivo functional imaging studies revealed that associative memory formation is coupled to a cascade of neural plasticity events in distinct compartments of the mushroom body (MB)....

jneurosci.org
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PDP localizes in the mushroom body a'3 compartment, but increasing the intensity of the CS pathway electrical stimulation extends PDP to the a3 compartment as well. PDP also requires an intact 3'UTR of CaMKII mRNA, which is important for localizing CaMKII to the synapse. (4/5)
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Finally, the formation of PDP requires nighttime sleep, as 12-hour sleep deprivation at night blocks PDP formation in the next morning. However, even in the sleep deprived flies, a minimum of 2 hours of rest in the morning recovers the ability for PDP formation. (5/5)
Real Houseflies of Brandeis retweeted
Instituto de Neurociencias UMH-CSIC@NeuroAlc18 May 2022
📢 Special Seminar by Leslie Griffith @GriffithFlyLab on new mechanisms for generating subcellular biochemical asymmetries relevant to neuronal function. 🔥 Don't miss it‼️ 🗓️ June 8th, 16:00h @NeuroAlc @CSIC @UniversidadMH @CSICval
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Our new paper is officially out: authors.elsevier.com/c/1f2ob… Local enrichment of CaMKII in MB is achieved via enhanced axoplasmic translation of CaMKII mRNA, through a mechanism requiring the RNA-binding protein Mub and a 23-base Mub-recognition element in the CaMKII 3′ UTR.
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Perturbation of either dramatically reduces axonal, but not somatic, CaMKII protein without altering the distribution or amount of mRNA in vivo. This axonal enrichment of CaMKII is necessary for cellular plasticity and associative memory formation.
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Karla Kaun@karlakaun21 Apr 2022
Thanks everyone! I'm truly honored and excited to be IBANGS President-elect. Let me tell you why... 🧵
I.B.A.N.G.S@IBANGStweets20 Apr 2022
Big News! IBANGS Election Results. Congratulations President-Elect: Karla Kaun, Brown University and Member-At-Large: Paul Meyer, University of Buffalo. We look forward to you tenure. @karlakaun @pauljohnmeyer @BrownUniversity @UBuffalo
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