Natural Scientists
Berlin, Germany
Joined February 2019
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Major work out in @NaturePhysics!
Led by @NicaGutu & Malthe Nordentoft — a multi-lab collaboration.
We show that the degree of circadian coherence between cells tunes proliferation rate 📈.
Disrupting coupling breaks clock–cell cycle coordination.
👉rdcu.be/efNaY
Granada Lab retweeted
It’s a wrap! My final PhD paper in the @Granada_Lab just came out in @CellReports🥳 We identified circadian rhythm heterogeneity and distinct time-of-day drug sensitivity dynamics across neuroblastoma cell models⏰ Thanks to everyone who shaped this work! rb.gy/j7z0sj
Granada Lab retweeted
Stay up to date with the latest research from e:Med by e:Medium Flash, March edition sys-med.de/en/current/emediu…
Huge team effort including @AnnaMarieFinge1, @CarolinEctor & many others — grateful for such a collaborative group. Very thoughtful reviewers’ feedback helped strengthen the work.
Thanks to @medicine_e, @BMBF_Bund & @ChariteBerlin for supporting this project!
Our latest work is out in @CommsBio. Led by @NicaGutu & Hitoshi Ishikuma, we study how circadian rhythms shape time-of-day drug sensitivity in human cells 🕒💊. Toward time-based cancer therapy.
Supported by @medicine_e, @BMBF_Bund @ChariteBerlin
👉 rdcu.be/ee3FQ
Happy to share a new very exciting work from my lab! Congrats to @CarolinEctor and the team on their study of circadian clock dynamics in breast cancer cells, now published in @MolSystBiol. @medicine_e @ChariteBerlin funded by @BMBF_Bund
Excited to announce that my second study with the @Granada_Lab, where we elucidated diverse circadian clock dynamics across breast cancer cells and their effect on drug sensitivity, has been published in @MolSystBiol. Thank you to the entire team! embopress.org/doi/full/10.10…
🚀 Together with @CarolinEctor, we recently published a review in Deutsches Ärzteblatt on Chronobiology in Oncology. Timing therapies for optimal effectiveness! ⏰💊
📌 Currently only in German.
🔗 aerzteblatt.de/archiv/chrono…
#Oncology #Chronobiology #MedicalResearch #CancerTreatment
Exciting to see this out! Congrats to @Anton36193637 and @shaon_chak ! — fantastic work all around!
Big shoutout to @Anton36193637, who drove this project over the last 4 years, working hard to make sense of all the noisy datasets using carefully designed models and statistical inference techniques. Thanks also to @Granada_Lab for the discussions and collaboration! (6/6)
New Preprint from our lab, led by @CarolinEctor! We performed deep circadian phenotyping in breast cancer cell lines, uncovering circadian-based subtypes and showing the clock’s role in drug response, predicting drug sensitivity. #circadianbiology #breastcancer @BMBF_Bund
Circadian clock features define novel breast cancer subtypes and shape drug sensitivity biorxiv.org/cgi/content/shor… #biorxiv_cancer
Thanks to @medicine_e, @BMBF_Bund, @ChariteBerlin
& @DKTK_ for the support! #CancerResearch #Chronotherapy
Grateful for the excitement around our work on the best time-of-day for drug treatments! Thanks to everyone highlighting the emerging science of chronotherapy—a field built on the pioneering work of many we admire.
News summary in 7 languages: nature.altmetric.com/details….
@SRBRHQ
Granada Lab retweeted
Very nice article from @Inside_PM, highlighting our recent work published in @NatureComms: insideprecisionmedicine.com/…
Granada Lab retweeted
Chemotherapie morgens, mittags oder besser abends? Forschende der #CharitéBerlin haben eine Methode entwickelt, mit der der optimale Zeitpunkt für eine Krebsbehandlung bestimmt werden kann. Ihren Ansatz beschreiben sie im Fachmagazin @NatureComms. charite.de/service/pressemit…
ALT Mikroskop-Bild einer triple-negativen Brustkrebszelllinie. Die Zelllinie exprimiert einen Marker für den Zellkern, der für die Echtzeit-Quantifizierung von Zellen genutzt wurde, um die Empfindlichkeit der Zellen zu verschiedenen Tageszeiten zu bestimmen. © Charité | Granada Lab
Granada Lab retweeted
Chemotherapy in the morning, at midday, or evening? Researchers at #CharitéBerlin have developed a method to determine the optimum time of cancer treatment. They describe their approach in the journal @NatureComms. charite.de/en/service/press_…
ALT Image of a triple-negative breast cancer cell line (MDAMB468), taken with a widefield microscope. The breast cancer cell line expresses a marker for the nucleus, which was used for real-time quantification of cells to determine the sensitivity of the cells at different times of the day © Charité | Granada Lab
New publication from our group! 🎉 Congrats to all authors, led by @CarolinEctor . We developed a method to use tumor cells' internal clocks to optimize cancer therapy. Thanks to @medicine_e , @BMBF_Bund , @ChariteBerlin & @DKTK_ for the support! #CancerResearch #Chronotherapy
Excited to share the publication of my first paper in
@NatureComms, introducing a comprehensive approach to study time-of-day effects of anti-#cancer drugs ⏰
Many thanks to the whole team, especially Adrián @Granada_Lab! Check out our work here: nature.com/articles/s41467-0…
Granada Lab retweeted
News from the e:Med Research Community - e:Medium Newsletter Volume 7 is available here: sys-med.de/en/current/emediu… #systemsmedicine #newsletter @KonradAden @Granada_Lab
Granada Lab retweeted
THANK YOU!!!! to the AMAZING cell signaling community for a fantastic inaugural Dynamics and Encoding in Cell Signaling FASEB meeting. We look forward to getting together in 2026!
Finally out! "Circadian Coupling Orchestrates Cell Growth"! Our study shows how circadian synchronization impacts the coordination of cellular division, shaping collective growth dynamics. Kudos to @NicaGutu! biorxiv.org/cgi/content/shor…
Excited to present at #SRBR2024 @SRBR_Outreach! Join us Wednesday morning for Symposium 17 on Circadian Medicine. Grateful for the support from @medicine_e, @BMBF_Bund, and @ChariteBerlin. #CharitéBerlin
Check out our latest pre-print! Kudos to Carolin Ector and a stellar team of collaborators for their immense effort. We've pioneered a novel high-throughput method to assess how circadian rhythms influence cellular response to drug perturbation. biorxiv.org/content/10.1101/…
