@GiusToLab

Assistant Professor of Neurology @ColumbiaMed #PopulationGenetics #Epidemiology #Neuroscience #Alzheimer #ENDALZ 🏳️‍🌈

 New York, NY
neurology.columbia.edu/research/research-labs/giusto-lab
Joined October 2021
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  • Following199
  • Followers129
33Media
Africa is making history with its first large-scale Alzheimer’s datasets 🧠✨ Read more in the link!
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Presenting my preliminary results of APOE e4 and Ptau 217 over cognition in quechua and aymara population from GAPP study at #AAIC25 in Toronto. Thanks to @GiusToLab, @NiltonCustodio8 @marciosotoanari
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How does APOE status impact AD risk in Hispanics/Latinos? Research in A&D report APOE ε4 shows a heterogeneous effect on ADRD risk across Hispanic/Latino populations, with the strongest associations in Peruvians/Bolivians #AlzResearch alz-journals.onlinelibrary.w…
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What does heritability mean as measured multiple ways and what does it mean for our understanding of Alzheimer's? Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review medrxiv.org/content/10.1101/…

Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates...

Estimating heritability has been fundamental in understanding the genetic contributions to complex disorders like late-onset Alzheimer’s disease (LOAD), and provides a rationale for identifying...

medrxiv.org
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1/ Even in the era of single-cell RNAseq, bulk-RNAseq data are still very valuable. 10 tools/papers related to bulk-RNAseq deconvolution.🧵
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I’m so excited to share our latest research, a fine-mapping method CARMA, in Nature Genetics! CARMA has flexible prior specifications, integration of high-dim annotations, and dealing inconsistencies in meta-analysis. #NatureGenetics #GWAS @NatureGenet nature.com/articles/s41588-0…

CARMA is a new Bayesian model for fine-mapping in genome-wide association meta-analyses

Nature Genetics - Causal robust mapping method in meta-analysis (CARMA) studies incorporates flexible prior distributions, joint modeling of summary statistics and functional annotations and...

nature.com
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Part of the amazing GAPP team in #AAIC2022
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Our preprint on rare variant associations in the UK Biobank exomes has now been updated to its final release of 450K exomes: medrxiv.org/content/10.1101/… and the browser updated to the latest association set: genebass.org/ - Happy exploring!
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Please RT! This is a wonderful _fully funded_ summer opportunity for undergraduates @Columbia thanks to @NIH & @alzassociation @CeriseElliott @HeatherAlz
STAR U Columbia University@STARUColumbia18 Nov 2021
The STAR U application for the 2022 cycle is NOW live! Please help us spread the word to undergraduate scholars who are interested in gaining a mentored research experience in #brain #aging next summer! Students can apply only by January 15th, 2022: neurology.columbia.edu/educa…
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