Lausanne, Switzerland
Joined February 2013
Des bactéries anciennes sur le continent américain rts.ch/audio-podcast/2026/au… Un projet collaboratif que nous avons publié dans Science, et qui apporte un éclairage nouveau sur l'origine et l'évolution de Treponema pallidum.
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Genomic and spatial epidemiology: lessons learned from SARS-CoV-2 pandemics journals.lww.com/co-hivandai…
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Genomic and spatial epidemiology: lessons learned from SARS-CoV-2 pandemic (by Yangji Choi et al) journals.lww.com/co-hivandai…
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Syndromic approaches for sexually transmitted infections - a review journals.lww.com/co-hivandai…
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Did SARS-CoV-2 Also Contaminate Swiss Mass Media? A Retrospective Analysis of French-Speaking News Articles During the First Pandemic Wave mdpi.com/3210596 #mdpicovid via @MDPIOpenAccess
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Fantastic outreach project in the form of a board game by @unil colleagues. Reinforces Lausanne as the probable world capital of microbiology-themed educational games! (Cue @GilbertGreub’s MyKrobs mykrobs.ch/en/)
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Our latest: Using de novo protein structure prediction and sensitive sequence searches we found many new eukaryotic signature proteins in Asgard archaea, suggesting the archaeal ancestor of eukaryotes was more complex than previously assumed. @koestlste biorxiv.org/content/10.1101/…
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#MDPIDiagnostics #OpenAccess #microbiology "The Impact of Laboratory Automation on the Time to Urine Microbiological Results: A Five-Year Retrospective Study" by Antonios Kritikos et al. @GilbertGreub 📄Read the full paper here: mdpi.com/2075-4418/14/13/139…
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We show mbPE can make single base pair substitutions, multiple substitutions, insertions and deletions. Basically all you need. There are still some limitations such as the max length of insertions (~50bp) and deletions (~127bp)
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For simple mutations and small insertions, selection efficiency is >90%!
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While DNA double strand breaks are a serious issue in eukaryotic systems, for smaller bacterial genomes that do not contain NHEJ, this is not necessarily a problem. Therefore we changed to a nuclease-based system which we called Make-or-break prime editing (mbPE).
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