@GeneTools

Gene Tools, LLC manufactures Morpholino antisense oligos for binding RNA and blocking processes.

 Philomath, Oregon
gene-tools.com
Joined October 2011
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SMCHD1 is a target for gene activation therapy to treat Prader-Willi syndrome doi.org/10.1126/sciadv.aej57…

SMCHD1 is a target for gene activation therapy to treat Prader-Willi syndrome

Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by loss of expression from the active paternal allele at an imprinted cluster on chromosome 15. Current treatments address indivi...

science.org
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TRPM2 couples cell-autonomous type-I interferon signaling to pigmentation homeostasis doi.org/10.1016/j.jbc.2026.1…
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Loss of nono impairs cardiac morphogenesis and excitation–contraction coupling via the PI3K/Akt pathway in zebrafish nature.com/articles/s41598-0…

Loss of nono impairs cardiac morphogenesis and excitation–contraction coupling via the PI3K/Akt...

Scientific Reports - Loss of nono impairs cardiac morphogenesis and excitation–contraction coupling via the PI3K/Akt pathway in zebrafish

nature.com
20
MicroRNA miR-219 is required for neural border and neural crest development in Xenopus neurulas doi.org/10.1016/j.ydbio.2026…
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LncRNA TAAL Regulates TIE1-Mediated Vascular Remodeling and Is Associated With Diabetic Retinopathy doi.org/10.1161/ATVBAHA.126.…

LncRNA TAAL Regulates TIE1-Mediated Vascular Remodeling and Is Associated With Diabetic Retinopathy...

BACKGROUND: TIE1 is an endothelial receptor tyrosine kinase, which plays a crucial role in vascular development and remodeling, including in diseases such as diabetic retinopathy (DR). However, the...

ahajournals.org
7
Delivery architectures for oligonucleotide therapeutics in genetic and rare diseases: GalNAc-based hepatocyte targeting and extrahepatic translation doi.org/10.1016/j.jconrel.20…
35
Identification of Sodium/Myo-Inositol Transporter 1 as a Major Determinant of Arterial Contractility doi.org/10.1096/fj.202600244…

Identification of Sodium/Myo‐Inositol Transporter 1 as a Major Determinant of Arterial Contractility

The tonicity-responsive enhancer binding-protein (TonEBP) and serum glucocorticoid kinase (SGK) sense a rise in extracellular hypertonicity resulting in an increase SMIT1 membrane abundance in...

faseb.onlinelibrary.wiley.com
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Plag1 Regulates Sensorimotor Modulation in Zebrafish doi.org/10.1002/jdn.70185

Plag1 Regulates Sensorimotor Modulation in Zebrafish

PLAG1 regulates early neurobehavioural development in zebrafish. Reducing plag1 alters craniofacial patterning, increases thigmotaxis and changes responses to light and acoustic stimuli, while gross...

onlinelibrary.wiley.com
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Downstream of β-catenin: A positive feedback loop between Goosecoid and Nodals in Spemann’s organizer doi.org/10.1073/pnas.2610127…

Downstream of β-catenin: A positive feedback loop between Goosecoid and Nodals in Spemann’s...

We report on the role of the homeobox gene goosecoid (gsc) within an epistatic pathway that mediates body axis formation in Xenopus. Embryos deplet...

pnas.org
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Improving the beneficial effects of HDAC8 inhibition by simultaneously activation of SIRT1 in a zebrafish model of Duchenne muscular dystrophy doi.org/10.1016/j.phrs.2026.…
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VARS2 deficiency drives seronegative myasthenia gravis pathology via mitochondrial, immune, and neuromuscular dysregulation doi.org/10.3389/fimmu.2026.1…

Frontiers | VARS2 deficiency drives seronegative myasthenia gravis pathology via mitochondrial,...

Seronegative myasthenia gravis (SNMG) is a clinically heterogeneous subtype of myasthenia gravis (MG) that lacks the classical pathogenic autoantibodies used...

frontiersin.org
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Improved nucleic acid sensing, exemplified using pure target DNA sequences, by MO capture probes compared to DNA capture probes, as revealed from PO2−, PO3− and nucleobase mass peaks doi.org/10.1039/d6ra03286
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Mechanical interactions dynamically influence rosette morphogenesis in the migrating zebrafish posterior lateral line primordium doi.org/10.1242/dev.204973

Mechanical interactions dynamically influence rosette morphogenesis in the migrating zebrafish...

Summary: Local interactions that promote epithelial rosette formation are opposed by tension associated with migration, which inhibits their formation, influencing the number and size of nascent...

journals.biologists.com
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SPEF1 mediates assembly of central pair microtubule complexes in cilia of Tetrahymena doi.org/10.1242/jcs.264648

SPEF1 mediates assembly of central pair microtubule complexes in cilia of Tetrahymena

SPEF1 is a conserved calponin-homology domain protein that decorates the seam of central pair microtubules in the distal segment of motile cilia. Here, we show that in the ciliate Tetrahymena, loss...

journals.biologists.com
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Placode-derived orphan chemokine CXCL14 is critical for proper chick trigeminal ganglion formation doi.org/10.1016/j.ydbio.2026…
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Tmlhe deficiency induces neurodevelopmental dysfunction and synaptic excitatory/inhibitory imbalance linked to autism-like phenotypes in zebrafish doi.org/10.1016/j.pnpbp.2026…
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SafeSense: An open-access safety atlas for antisense oligonucleotides adverse events in human doi.org/10.1016/j.omtn.2026.…
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Genetic evidence and cross-species functional characterization implicate CNN2 in age-related macular degeneration susceptibility doi.org/10.1073/pnas.2533682…

Genetic evidence and cross-species functional characterization implicate CNN2 in age-related...

Age-related macular degeneration (AMD) is a leading cause of irreversible visual impairment in the aging population globally. Although genome-wide ...

pnas.org
20
Tissue flow acts as a guidance cue for immune cell polarization and directional migration nature.com/articles/s41556-0…

Tissue flow acts as a guidance cue for immune cell polarization and directional migration

Nature Cell Biology - Le et al. show that in Xenopus embryos, local ectodermal tissue flows provide a directional cue that polarizes and guides embryonic myeloid cells migration via cell-on-cell...

nature.com
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NF2 lacking exon 11 induced by antisense gene therapy is able to partially recover merlin deficiency in NF2-SWN iPSC-derived spheroid model doi.org/10.1016/j.omtn.2026.…
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