DYK that lymph nodes fight infection by housing white blood cells that destroy bacteria&viruses? This nodeworthy CODEX image of a lymph node TMA was made by Negin Farzad in Rong Fan’s lab at @Yale. Much like a lymph node that just spotted a foreign body we’re swelling with pride

I am building an extremely sophisticated biomedical science application with GPT-6 Astra for analyzing flow cytometry data. Flow cytometry is one of the most essential technologies in immunology. It allows us to analyze tens of thousands, or even millions, of individual cells from blood, tissues, or other samples, using fluorescently tagged antibodies that identify specific cell types and measure the proteins they express. It's like our window into the world of the cells. For decades, labs like mine have paid thousands of dollars every year in subscription and licensing fees for commercial software to analyze these datasets. I have canceled all my subscriptions 😊 I have now almost built a fully functional, research-grade version of such an application with Astra! It already has a better UI/UX than many of the tools I have used, and my goal now is to make it even better than the leading commercial applications in this field! I had in fact built earlier basic versions using previous Codex models, but this is the first time I have reached a version that works exactly the way I want it to, with the interface, analysis workflow, and features behaving almost perfectly. Previous versions took a lot of efforts with many bugs to deal with, with Astra you get what you ask for almost the first shot! It's just unbelievable! And this is only one project. I have several other highly complex biological and biomedical software applications in my Astra pipeline. At this point, my main bottlenecks are basically token limits and the number of hours I can stay awake and massive coffee stocks! 😂 It is just incredible to think that scientific software that once required specialized development teams, years of engineering, and sometimes million dollar budgets can now be built by someone like me who has no software engineering experience! With Astra you can just do things! ✨

SCI member Kara Davis & others review how lineage switch drives aggressive acute #leukemia relapse, especially under pressure from targeted immunotherapies. Researchers offer guidance for diagnosis, monitoring, and future treatment strategies. brnw.ch/21x5asj

I joined UAP Science Advisory Council members Garry Nolan, Peter Skafish, and Anita Goel to discuss the Council’s work and the scientific path forward on UAP. I am grateful to Peter and Garry (@GarryPNolan) for their thoughtful advice as we navigate this important issue, and proud to welcome Anita (@Nanobiosym) as a new member of the Council. Her expertise will be a valuable addition to our efforts.

JACQUES VALLÉE’S FINAL WARNING After nearly seventy years spent investigating the UFO Phenomenon, Jacques Vallée appears to be stepping away from public-facing research without providing the clean conclusion so many people desperately want. If anyone had earned the right to give us a definitive answer, it would be him. Yet his final journal reportedly names no species, confirms no singular origin, and offers no triumphant announcement that the truth has finally been revealed. What remains is far more difficult, which is the possibility that our demand for a simple answer is itself part of the problem. Vallée’s work has long pointed toward something larger than biological visitors arriving from another planet. The extraterrestrial hypothesis may explain metallic craft and physical occupants, but it struggles with missing time, symbolic encounters, psychic effects, religious parallels, the manipulation of consciousness, and the apparent ability of the Phenomenon to alter its presentation across cultures and historical periods. Something that changes its form alongside human belief, while producing effects within both matter and mind, does not behave like a conventional expedition from another world. This is why I have never been comfortable placing the entire Phenomenon inside one explanatory box. Extraterrestrial visitors may absolutely be part of the picture. But if we force every encounter into that framework, we risk discarding the very characteristics that make this mystery so profound. Most unsettling is Vallée’s suspicion that “Disclosure” itself could become the next stage of the old cover-up. Disclosure can occur without revelation. A government could acknowledge that something is present while retaining control over the evidence, vocabulary, and boundaries through which the public is permitted to understand it. By reducing the Phenomenon to military incursions, sensor anomalies, and threats to national security, its relationship with consciousness, mythology, religion, and human transformation disappears from view. The admission would be real. So would the containment. After seven decades, Vallée’s most honest conclusion may be that premature certainty is dangerous. Naming the Phenomenon too early could reduce it to something we already understand. Once that frame becomes fixed, everything that refuses to fit can be dismissed as irrelevant. Something real is happening. It leaves traces in matter, enters consciousness, and appears capable of influencing human belief across entire cultures. Whatever intelligence exists behind it, assuming there is only one, may not respect our distinctions between physical and psychological, technology and mythology, or even past, present, and future. Vallée may not be leaving us without an answer. He may be leaving us with a far more difficult responsibility: resisting the comfort of one. #ufox #ufotwitter

Catching skin cancer early is a home robotics problem. Melanoma is highly treatable when detected early, yet today’s screening process depends heavily on patients noticing tiny changes across their entire skin surface. This requires patients to solve a near-impossible visual-memory and registration problem. I built OpenDerm, an open-source 4-DOF robot that captures high-resolution images of the skin and uses them to reconstruct and track the skin surface in 3D over time. The best way to make skin screening truly routine is to bring it into the home. OpenDerm shows that inexpensive robotic skin imaging is possible, but the path to scale is not a dedicated screening robot in every household—it is to make skin screening one of the many useful things a general-purpose home robot can do. Read more about why I built OpenDerm and how it works here: Blog: marionlepert.github.io/blog/… Project: openderm.github.io/