@GLiperis

Consultant Embryologist | Senior Lecturer University of Sydney | ESHRE certified Senior Embryologist | Views my own

 Sydney, New South Wales
Joined January 2021
  • Tweets2.4K
  • Following684
  • Followers1.2K
237Media
Replying to @SCobanMune
@SCobanMune @OmarRawi89 @GLiperis @Repro_Fertility @zaliheyarkiner @berilyuksel @marcos
Dr. Georges Raad@Dr_Georges_RaadMay 11
In our newly published study, vitrification media temperature was associated with markedly different blastocyst development outcomes despite comparable survival and fertilisation rates. 🔗 doi.org/10.1530/RAF-26-0003 #IVF #Embryology #oocyte #eggfreezing
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🎉 Scientific Speed Dating returns at #ESHRE2026 in London! 👩🏼‍🔬 Junior professionals don’t miss this chance to connect with leading experts. 💡 Exchange ideas, spark collaborations&discover opportunities. 👥 Secure your spot ! Co-organised by the #ESHREjc&young talent group
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eshre.eu/ESHRE2026/Programme… @OmarRawi89 @juanjo_fraire @NoemiSalme30386 @AttilioDGM7 @DKalaitzopoulos @Saara_riibeiro @MairaCasalechi Julie LABROSSE #ESHRE
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🧬 The Oocyte Cortex: Fertility’s Hidden Control Layer To find out join #ESHREjc on Friday 29th of January starting at 17:00 CET. @paolavigano @rvassena Enrica Bianchi and authors Giovanni Cotichio and Danilo Cimadomo Paper ➡️ pubmed.ncbi.nlm.nih.gov/4120… 🧵 #bluetorial 👇🏻

The emerging role of the oocyte cortical domain in maturation, fertilization, and development -...

The cell cortex, a cytoskeletal network with regulatory signalling pathways, is localized beneath the cell membrane: it is especially prominent in mammalian oocytes. As in other cells, the cortex...

pubmed.ncbi.nlm.nih.gov
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🌟 Conclusion The oocyte cortex is a biomechanical decision-making layer controlling fertility, genome stability, and embryo survival and a powerful future tool for non-invasive IVF diagnostics. #ESHREjc
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💉 ICSI = A Cortical Stress Test Injection funnel shape & persistence reflect cortical health and predict fragmentation, blastocyst quality, and pregnancy outcomes. #ESHREjc
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📊 IVF Insight Mechanical tests show:
Cortical stiffness predicts blastulation better than morphology alone. Biomechanics > embryologist grading #ESHREjc
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🎯 Cortex Stiffness Tunes Chromosome Fidelity Too stiff?
Too soft?
→ Both cause spindle failure and aneuploidy. There is a narrow “Goldilocks zone.” #ESHREjc
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⚡ Fyn Kinase = Cortical Master Regulator Loss of Fyn → defective actin cortex, failed polar body extrusion, abnormal zona pellucida, chromosome errors → subfertility. #ESHREjc
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🧱 Actomyosin Engineers the Cortex ERM proteins+actin+myosin sculpt polarity, actin caps, and spindle migration. Disruption = misalignment, meiotic arrest, aneuploidy. #ESHREjc
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⚖️ Mechanical Polarity • Low-tension microvillar domain → sperm fusion
• High-tension amicrovillar domain → spindle anchoring
A 2.5× tension difference controls asymmetric division. #ESHREjc
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🌀 Meiosis Triggers Cortical Remodelling TZPs retract → cortex reorganises → asymmetric forces reposition the spindle → polar body extrusion becomes possible. Bad cortex = poor embryos. #EHSREjc
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🔁 Bi-directional Signalling Through the cortex:
• CC → oocyte: metabolites, meiotic arrest
• Oocyte → CC: BMP15, GDF9
→ Oocyte competence depends on cortical signalling. #ESHREjc
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🦄 Oocytes Are Different Typical cell cortex: 50–400nm Oocyte cortex: ++ Thick ➡️ Thickness: Specialised functions. 🤝 Cortex: Communication Hub Hosts transzonal projections (TZPs): actin bridges that connect cumulus cells&oocyte, delivering nutrients and signals. #ESHREjc
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🧶 The oocyte cortex is not just a membrane lining. It’s a specialised micromechanical command centre that controls meiosis, fertilisation, embryo integrity, and IVF success. #ESHREjc
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🚨 Is the oocyte cortex the hidden key to egg quality, fertilisation, and embryo development? Join us for the next #ESHREjc 🗓 30–31 January ⏰ 17:00 CET start 📍 on @ESHRE academic.oup.com/humrep/arti… Experts 👉🏻 @RitaVassena @PaolaVigano3
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The new channel for science dissemination. Dont miss our #ESHREjc discussions also being hosted on bluesky 🦋 from ➡️ January 2026
ESHRE@ESHRE15 Dec 2025
Hello Bluesky friends! 💙🦋 We’re settling in nicely and enjoying every new connection. If you haven’t said hi yet, drop by @eshre.bsky.social - our door is always open. #ESHRE #WeAreOnBluesky #ReproductiveHealth #FertilityScience #NewToBlueSky #MedicalResearch #Infertility
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Replying to @GLiperis @ESHRE @OmarRawi89 @juanjo_fraire @NoemiSalme30386 @juliauraji @AttilioDGM7 @FabrizzioHorta
I totally agree with you @GLiperis. The problem is that the alternatives do not appear to be less harmful than paracetamol. I think the main rule for paracetamole should be "use the lowest effective dose in the shorter time" and for sure not prophylactic #ESHREjc
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Replying to @juanjo_fraire @catiamalinina @Kristensen8511 @OmarRawi89 @ESHRE @juliauraji @AttilioDGM7 @GLiperis @Saara_riibeiro @NoemiSalme30386
I believe that, from a design perspective, it should not be difficult to conduct a retrospective clinical study examining the effect of paracetamol exposure during ovarian stimulation or embryo transfer, in order to obtain clinical evidence.
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The 4th discussion point on circumventing strategies #ESHREjc Join the discussion 👇🏻
Kalaitzopoulos Dimitrios Rafail@DKalaitzopoulos28 Nov 2025
Q4: #ESHREjc Until prospective data arrive, what’s a proportionate counseling message for TTC/IVF patients needing analgesia, what alternatives, what timing advice, and how to avoid over-restriction that drives unsafe NSAID substitution? @ESHRE
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