MGH Heart Failure Section Head, Med Director of Heart Transplant, Prof of Medicine at HMS, with interests in heart failure and applied exercise physiology.

Boston
Joined September 2019
Just published in Circulation- a multi-institution collaborative team effort that leverages insights from invasive cardiopulmonary exercise testing to further understand HFpEF. lnkd.in/eVuF7SkF
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To be published in Circulation tomorrow and featured on Circ on the Run today, we describe easily-derived cardio-specific VO2 recovery measures in #HFpEF and their modifiability w/aficamten in oHCM. @CampainJoseph @MGHMedicine @MGHHeartHealth circulation.libsyn.com/circu…
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Greg Lewis retweeted
Read the largest CPET meta-analysis in hypertrophic cardiomyopathy (N=12,914), pVO2 and VE/VO2 slope potently predict mortality and CV events. #AHAJournals @Landsteiner_I @GLewisCardiol @MGHHeartHealth ahajrnls.org/3KAgKxE
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Our just-published meta-anal of 60 observ studies shows CPET measures (pVO2, VE/VCO2) potently predict outcomes in HCM, complementing trials showing modifiability of CPET measures w/CMIs in oHCM. More to come from #MAPLE-HCM @ #HFSA LBCTs doi.org/10.1161/JAHA.124.039…
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📅 14 March 2026 – 9ᵗʰ #ExEcho Symposium 🇧🇪 Hybrid (Hasselt + Online) 🎯 Focus: #ExerciseEchocardiography ± #CPET 🩺 Live cases | Keynote by Greg Lewis (MGH) 💡 Free & in English 🔗 Program below ⬇️ #cardiotwitter #echofirst #CPETecho
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Congratulations Isabela on your well deserved award!
Grateful to @ISHLT for this award plate! I’m truly honored to have this work recognized and want to sincerely acknowledge the MGH CPET Lab and @GLewisCardiol—whose mentorship, dedication, and support have been integral to this journey. @MGHHeartHealth
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Very proud of @Landsteiner_I who just won the 2025 Philip K. Caves Award for outstanding original research by a fellow/grad student @ISLHT, showing that exercise hemodynamic profiles predict HF and PH-specific outcomes in patients w/normal resting hemodynamics. @MGHHeartHeath
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Such an honor to be invited to the Congregational Church of Brockton for an educational session on heart failure & CVD! It was an energized Q&A session with eagerness to participate in the NIH @HeartShareStudy. @MGHHeartHealth
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#THT2025 will welcome the heart failure community to Boston in 2 days! I am thrilled to have 2 talented #MGHCVRC postdoctoral fellows, @winkoma_cardio and @Landsteiner_I presenting work on #HFpEF in the Fellows Outstanding Abstract Competition on 2/11. @MGHHeartHealth @crfheart
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Medscape\HFSA New Paradigms in Hypertrophic Cardiomyopathy starting in 20 min! Events.medscapelive.org. Looking forward to this session with Sara Saberi and Marty Maron!
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The first Chicago Hemodynamic Forum was excellent!
“Stump the experts” trainee case competition underway @ChiHForum. First up @vkittipibul, trying to stop @DrNancySweitzer & members of the @CircHF editorial board #ChiHemos2024
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Now in press @JCardFail, during incremental ramp exercise, addition of 10+ upright invasive exercise hemodynamic measures is feasible with nearly identical peak RER, workload and VO2 to non-invasive CPET authors.elsevier.com/a/1jySB… More to come @ChiHForum
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It was inspirational to visit the thriving Vanderbilt Cardiology Division and Heart Failure/Transplant Program today for Cardiology Grand Rounds. Thank you @VUMC_Heart for hosting me today!
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Congratulations Donna! Very fitting recognition of your outstanding contributions to the field of HF.
This woman!!! @DonnaMancini11 - fitting recipient of the the @HFSA PIONEER award for her 🔥 trailblazing practice changing work in #FunctionNotFailure So proud & happy 😊🙌🏽 @NirUrielMD @mgtrivieri @DLBHATTMD @MountSinaiHeart @Drroxmehran @EricAdler17 @DukeHFDoc @robmentz @MKIttlesonMD @mrchrtfaildoc
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🔥Ready. Set. Go❗️The #heartfailure portion of the MGB Heart Failure & Shock course starts now with @GLewisCardiol @ErinCoglianese & Dr. Lana Tsao #heartsuccess #functionnotfailure @MassGenBrigham @MGHHeartHealth @harvardmed
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Published today in @JAMACardio. Cardiopulmonary Exercise Testing (#CPET) in clinical trials captures ∆es in ex. performance. In #oHCM, aficamten ↑peak VO2, ↑workload, ↑cardiac power, ↑ VO2 at AT & improved ventilatory efficiency. Our novel z-score integrating ∆pVO2 and ∆VE/VCO2 slope had p<0.000000001 favoring aficamten vs placebo. #SEQUIOA trial, @mghhearthealth jamanetwork.com/journals/jam…
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Responder analysis for changes in peak VO2 is shown below with moderate change >1.5ml/kg/min and large >3ml/kg/min.
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We hope you will come join us in Boston, live or virtually for part or all of the #MGB, Harvard Medical School #cardiogenicshock and #heartfailure CME course 9/12-9/14/2024! cmecatalog.hms.harvard.edu/m…
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Starting Now with Maria Rosa Costanzo, @DrNancySweitzer @JamesCFangMD leading things off!! hfsa.org/hfsa-ahftc-board-ce… AHFTC Board Certification Review with today’s faculty line up. @HFSA
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Dr. Roman DeSanctis was quintessential MGH- setting the bar for all of us who practice medicine with his combination of dedication to patient care, brilliance, and humility. I count myself among the many who are forever indebted to you Roman, RIP.
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