GI Pearls retweeted
Our new paper in @NatImmunol explores this question through PPARδ, a lipid-sensing transcription factor that we identify as a regulator of the #fitness balance between #cancer and #immune cells. You can read the open access paper here: nature.com/articles/s41590-0…
GI Pearls retweeted
Now a jury has awarded David $6 million for defamation and tortious interference. The Boston Globe and The New York Times soon after reported the outcome. Science despite running countless negative articles shaming David is nowhere to be found today.
Science repeatedly portrayed David’s efforts in court as futile or unsuccessful by emphasizing selected pretrial rulings on court motions while significant claims were still awaiting trial. Those decisions did not determine the outcome of the claims the jury has now decided.
This goes beyond leaving out part of the story. Relentlessly publishing damaging allegations fuels the public shaming and online bullying of a person. That carries a responsibility to give a verdict in his favor comparable visibility—and to account for the narrative those articles helped establish.
David has lived with the consequences of this coverage for years. Science owes him a prominent account of this verdict and a serious reckoning with its own role in the spectacle.
My friend David Sabatini continues to be relentlessly targeted by gossip-driven tabloids pretending to be trusted scientific institutions. Science magazine’s latest piece is yet another one-sided hit job — downplaying or ignoring that the legal outcome was mixed, with some claims proceeding to trial and others moving to appellate review.
I’ve spoken to dozens of his former lab members, all of whom describe him as a generous and dedicated mentor. I’ve also talked to many women who worked closely with him and never had concerns about anything resembling a sexualized work environment. Yet most remain silent.
David was railroaded in a metoo-era mob campaign amplified by click-hungry reporters and social media trolls. All he’s ever wanted is to return to doing science — the work that defined his life.
As long as Science and outlets like it continue pretending to be arbiters of truth while operating as gossip mills, reputations will keep being destroyed - and truth will remain secondary to spectacle.
science.org/content/article/…
GI Pearls retweeted
Today, a civil jury ruled in favor of Cambridge scientist David Sabatini in his defamation suit, awarding him $6 million in damages.
We were the first to report on his story.
It deserves another read:
thefp.com/p/he-was-a-world-r…
"It wasn’t so long ago that DEI offices had enormous power on campus, where they could sway hiring decisions or help bring down even world-renowned faculty members.
Just ask David Sabatini. He was a molecular biologist working in Cambridge to figure out a protein called mTOR, which plays a critical role in tumor development, and he was at the top of his field. His research laid some of the groundwork for drug discoveries around organ transplantation and cancer treatment, and he was predicted to win the Nobel Prize. But Sabatini was fired in August 2021 from the job that paid his salary and resigned from two others, his name and reputation destroyed.
He had been working in science for about 25 years without so much as a complaint, he told me. But then Kristin Knouse, a fellow researcher with whom Sabatini had a consensual relationship, accused him of sexual harassment. 'I lost everything,' he told me back in 2022. 'My whole life imploded.'"
—@SnoozyWeiss
GI Pearls retweeted
Other than physicians employed by ABIM/ABMS I have yet to find a physician in support of MOC.
Replying to @Papa_Heme
They are now putting ads out 😑
So the people fighting recert just be doing something right
GI Pearls retweeted
End ABIMs MOC
change.org/p/eliminate-abims…
GI Pearls retweeted
We thank our Lead Sponsor, Zcash, for supporting our conference.
Register today: conjectureinstitute.org/even…
GI Pearls retweeted
🛡️Defend the West Conference🛡️
WHEN: 1/13/2027
WHERE: Online
Over 300 people have registered so far.
Speakers include:
@DavidM_Friedman
@sapinker
@SRCHicks
@yaronbrook
@alananewhouse
@johanknorberg
@DeirdreMcClosk
@michaelshermer
@ToKTeacher
@jasoncrawford
Nadine Strossen
Save your spot (link below)
GI Pearls retweeted
If defending the West makes even a small part of you cringe (it does to me), then there’s work to do.
Conquer the cringe.
🛡️Defend the West Conference🛡️
WHEN: 1/13/2027
WHERE: Online
Over 300 people have registered so far.
Speakers include:
@DavidM_Friedman
@sapinker
@SRCHicks
@yaronbrook
@alananewhouse
@johanknorberg
@DeirdreMcClosk
@michaelshermer
@ToKTeacher
@jasoncrawford
Nadine Strossen
Save your spot (link below)
GI Pearls retweeted
Odd how the latest thing is whether or not one admits it's a genocide. I wonder what the thing will be next year.
Either way, I'll still be supporting Israel.
Oct 7 was clarifying for me. As @DouglasKMurray said it was like a flare went up and you could see where everyone was standing.
GI Pearls retweeted
A TIPS lowers portal pressure. Why does left portal vein flow reverse? 👀 Update on my portal pressure simulator: normal circulation → cirrhosis with ascites & varices → TIPS.
Anatomy, pressure circuits & live Doppler. Work in progress. @LiverFellow @AASLDtweets
#MedEd #Hepatology
GI Pearls retweeted
This episode is a colossal demonstration of the value of individualism over collectivism.
I am responsible for my child, and I do my best to give them the best. And I expect everyone else to do the same.
The alternative, collectivism, means that everyone is responsible for everyone else’s problems, as described by some central planner.
Not only does this produce a mess, it CANNOT do otherwise, because no central planner can know how people should live their lives.
One of the many layers of irony in this story is that this collectivist nonsense is not only taught, it is indeed practiced, perhaps nowhere more extremely, than in schools, institutions supposedly dedicated to propagating the values of the West. The West, which is able to spend $52k per public school student precisely because it identified the value of individualism.
It’s worse than pissing it away, it is poisoning the well.
GI Pearls retweeted
Long division is an ancient initiation rite. Teaching my kids to do it would feel as odd as teaching them to slaughter a goat in sacrifice to Zeus.
GI Pearls retweeted
The Sovereign Child in Spanish!
Mind is blown seeing this.
editorialtenos.com/collectio…
Replying to @editorialtenos
¿Qué pasa cuando damos más espacio a la autonomía, a la curiosidad y a la capacidad de los niños para aprender por sí mismos?
Con la vuelta al cole como telón de fondo, hemos reunido cinco ideas del libro para pensar y debatir con calma.
GI Pearls retweeted
Replying to @aryehazan @Benthamsbulldog
Science isn’t objective because it describes physical reality exactly (it doesn’t), it’s objective because it gets closer to an exact description.
Same with morality - it is the field of error correction in general, and it has principles that are objectively better than their alternatives.
Conservation of energy is to physics as be open to new ideas is to morality. Both objectively good principles for their fields.
GI Pearls retweeted
The efficiency-atrophy paradox: a critical issue re understanding AI deskilling and never-skilling in medicine.
h/t: @ProfCalNewport
Source: arxiv.org/html/2603.10025v2
GI Pearls retweeted
Look at the comments. Astonishing how disliked the AMA is by physicians and the public.
This is a good time to support CMS’s effort to dissociate the AMA from professional billing by physicians.
Nobody wants them involved
This comes from someone who was a huge supporter of the AMA until, like so many before me, got completely screwed over by them.
GI Pearls retweeted
Except - if they studied mood before and after a school day, they’d conclude that school turns sad kids happy.
Imagine studies of the effects of school on anxiety in the same way that @JonHaidt describes studies of the effects of smartphones on anxiety.
Survey kids on school. Assess their mood before and after 20 minutes of a classroom lecture or dreary homework. See how they feel at night when they’re told that they have to stop what they’re doing and go to bed because it’s a school night.
Imagine ignoring that monstrosity, and instead focusing on smartphones.
One of the many problems with inciting a moral panic about screens is the tacit endorsement of school as a legitimate cause of child suffering.
GI Pearls retweeted
On a list of bad changes in medicine few are worse than the loss of IN PERSON conferences in reading rooms. Remote radiology is TERRIBLE
Radiology used to have something that was almost invisible because it was so routine:
The reading room consult.
Rounding teams came down.
Surgeons pulled up their cases.
Internists brought the scan that didn't quite fit the clinical picture.
Sometimes the radiologist solved the problem.
Sometimes the clinician supplied one piece of history that completely changed how the images were interpreted.
And usually everyone simply walked away a little sharper.
But something else was happening during all of those conversations.
We were learning each other.
As a radiologist, I learned what individual physicians cared about.
I knew which findings mattered to a particular surgeon.
Which measurements an oncologist was following.
Which details a specialist wanted emphasized.
What questions they were really asking, even when the order just said "pain."
And they learned me.
They knew who was reading their study.
They knew they could walk in, point at something, challenge an interpretation, or ask, "What do you think?"
That relationship created context.
It created feedback.
It created trust.
And over years, it created a kind of institutional knowledge that never appears in the medical record.
When radiology becomes a report produced by someone hundreds or thousands of miles away, we don't just lose proximity.
We risk losing that entire feedback loop.
The report may still be technically excellent.
But the radiologist knows less about the physician.
The physician knows less about the radiologist.
The radiologist sees less of what happened after the report.
And both sides lose opportunities to make each other better.
The reading room was never just a room.
It was where imaging became part of the clinical conversation.
We should think very carefully before designing that conversation out of medicine.
Inspired by a conversation yesterday with @PaleoOnc . Also @909One and @brianchiong .




































