GordonD retweeted
๐๐๐๐ฉ ๐๐๐ฅ๐ฅ๐๐ฃ๐จ ๐ฌ๐๐๐ฃ ๐ฉ๐๐ ๐ข๐๐๐๐๐ฃ๐๐จ๐ข๐จ ๐ฉ๐๐๐ฉ ๐๐ฃ๐จ๐ช๐ง๐ ๐๐๐๐ช๐ง๐๐ฉ๐ ๐ฟ๐๐ผ ๐ง๐๐ฅ๐ก๐๐๐๐ฉ๐๐ค๐ฃ ๐๐ง๐ ๐๐๐จ๐ง๐ช๐ฅ๐ฉ๐๐?
๐ฌ In a new review article published in @MolMedBMC, researchers affiliated with the ๐๐ป๐๐ฒ๐ฟ๐ป๐ฎ๐๐ถ๐ผ๐ป๐ฎ๐น ๐๐ป๐๐๐ถ๐๐๐๐ฒ ๐ผ๐ณ ๐๐ป๐๐ถ๐ฐ๐ฎ๐ป๐ฐ๐ฒ๐ฟ ๐ฅ๐ฒ๐๐ฒ๐ฎ๐ฟ๐ฐ๐ต examine how dysregulation of DNA replication licensing factors contributes to genomic instability, tumor initiation, and cancer progression.
โค The review explores the roles of ORC, CDC6, CDT1, MCM proteins, and Geminin, highlighting how abnormal replication licensing can lead to replication stress, DNA damage, and ultimately tumorigenesis.
โค Importantly, the authors discuss the potential of these proteins as prognostic biomarkers and therapeutic targets, while emphasizing that their effects on cancer development and treatment response can vary depending on the cellular and tumor context.
๐ ๐๐ฆ๐ข๐ฅ ๐ต๐ฉ๐ฆ ๐ง๐ถ๐ญ๐ญ ๐ฐ๐ฑ๐ฆ๐ฏ-๐ข๐ค๐ค๐ฆ๐ด๐ด ๐ณ๐ฆ๐ท๐ช๐ฆ๐ธ:
doi.org/10.1186/s10020-026-0โฆ
Very important breakthrough in glioblastoma research. cell.com/cell/fulltext/S0092โฆ
GordonD retweeted
Iโve successfully run the full retained MaleCNS v1.0 fruit fly connectome, all 166,700 neurons, inside Minecraft, with its simulated neural activity driving a flyโs movement.
V1 Currently in development. Built with the help of GPT-6 Astra.
Props to the @OpenAI team and @thsottiaux for this release. Code and mod coming soon!
For the first time, scientists have mapped the complete brain and central nervous system of an adult male fruit fly โ a key model organism in science. ๐ชฐ
Working alongside HHMI Janelia Research Campus and the scientific community, @GoogleResearch scientists and researchers used AI to combine millions of 2D images into 3D neural shapes, reconstructing a record-breaking 166,000+ neurons. This foundational map of the adult male fruit fly brain can help accelerate our understanding of the brain, and is a major milestone in neuroscience.
ALT Vibrant 3D digital reconstruction of a fruit fly brain against a white background, displaying a dense, intricate network of multicolored neural fibers and cell bodies in shades of blue, cyan, orange, and purple.
ALT A complex 3D visualization of a fruit fly brain, featuring a dense, symmetrical network of thousands of tiny, multicolored neurons and fine, interconnected fibers in shades of blue, magenta, orange, and green against a solid white background.
GordonD retweeted
An advanced wearable with motor sensors captures growth metrics and motor growth charts in infants playing at home over the course of more than a yearโoffering an unparalleled ability to track early patterns in motor and neurodevelopment.
Find out more in @ScienceTM: scim.ag/4pLMksW
GordonD retweeted
GPT-5.6 Sol Pro appears to have proved the unrestricted exact-real-constant BSS version of Smaleโs 7th problem: O(N^11) operations, energy gap โค1/18, using one exact real as nonuniform advice. Iโm sharing the full proof for rigorous scrutiny.
zenodo.org/records/21508144
GordonD retweeted
Using more than 1.4 petabytes of electron microscopy (EM) imaging data, researchers generated a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, providing an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. โ
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The human brain is a vastly complex organ and, to date, little is known about its cellular microstructure, including the synaptic and neural circuits it supports. Disruption of these circuits is known to play a role in myriad brain disorders. Yet studying human brain samples in such great detail comes with a host of challenges, ranging from technological limitations to the availability and preservation of tissue samples from healthy individuals. โ
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In a 2024 Science study, researchers performed a high-resolution EM reconstruction of the ultrastructure of a cubic millimeter of human temporal cortex. According to the authors, the reconstruction contains roughly 57,000 cells, about 230 millimeters of blood vessels, and nearly 150 million synapses, comprising 1400 terabytes of data. The authors generated a three-dimensional reconstruction of nearly every cell and process in the cubic millimeter sample and developed a freely available tool for visualizing and analyzing the vast dataset.โ
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Learn more on #WorldBrainDay: scim.ag/41z2OJ4
GordonD retweeted
Explaining the passage of time has been a gnarly problem in physics basically forever, but physicist and computer scientist Stephen Wolfram has a radical proposal for where it comes from. He discussed his ideas on time โ and what they mean for free will... newscientist.com/article/253โฆ
GordonD retweeted
For decades, biology textbooks have enshrined a simple rule: DNA is made by copying a template. After one enzyme unzips a DNA double helix into separate strands, another called a polymerase builds a complementary sequence, base by base, for each strand. Presto: two copies of the original DNA.
But new research into how bacteria defend themselves from viruses now shows this synthesis rule isnโt absolute.
Now, a team describes a bacterial enzyme that synthesizes DNA without a nucleic acid template, using its own structure as a guide.
Learn more: scim.ag/4tTc5IA @NewsfromScience
GordonD retweeted
In the future, very few will die from cancer and heart disease.
But it's estimated that eliminating both completely only increases life expectancy by ~5โ10 years.
The real dramatic gains in life expectancy will be achieved by figuring out how to slow down or reverse biological aging.
Slide from @mkaeberlein
GordonD retweeted
๐จ Simulation Theory: The Double Slit Experiment proves particles act like waves until observed then they snap into particles.
What if our reality only "renders" when we're looking, just like a video game optimizing resources?
Check out this episode from The Why Files breaking it down, tying it to Simulation Theory. Are we in a sim?
This could be the key to unlocking the true nature of existence!
The Why Files video did a great job on explaining the Double Slit Experiment & Simulation Theory
What do YOU thinkโreal or rendered? Drop your thoughts below!
GordonD retweeted
#BTC is doing exactly as it should do during these later innings of the major corrective phase. BTC is in stage two of forming a real durable bottom on the 3D time frame. This process always sucks but it is necessary. The data is still showing a high probability of a bottom and a counter trend move anytime within the next 5 weeks back up to what used to be major support levels that are now resistance. Then from there many questions will be answered about the coming months for BTC. Not opinion, not emotions, just data.
Now that the weekly bearish divergences and corrective phase I have been tracking since Aug/Sept on BTC and Total 2 are in their later innings of fully playing out I am comfortable in saying with the backing of hard data that there will be a bottom formed and a counter trend rally in the coming weeks on #BTC and #Altcoins. The corrective phase is almost over. Just need a little more time to form a proper bottom
GordonD retweeted
In the past thirty years, the number of deaths from cancer has dropped dramatically, resulting in millions of lives saved.
Some of this is due to improvements in oncology treatments, including immunotherapy.
But most of the effect has little to do with biopharma at all.
GordonD retweeted
โUltraviolet radiation is a known carcinogen; there is no debate about that,โ empasizes Dr. Friedman @GWtweets. โWeโve had decades of data showing that sunscreen plays a critical role in reducing #SkinCancer risk.โ Debunk sunscreen myths @washingtonpost: wapo.st/3UpAeHh
GordonD retweeted
ALTCOINS ARE LOADING THE SAME MOVE AS 2021.
The setup is identical to 2021 but bigger.
Trajectory: $1.77T โ $7.66T.
Strap in. Because this time, rockets wonโt land.
Will you be on board?
GordonD retweeted
The number of people surviving cancer has significantly increased in the last 50 years. However, progress has been uneven, with some cancers with low survival rates falling further behind.
A new study from @LSHTM we funded has revealed a 92-percentage point gap in 10-year survival between the most & least deadly cancers. It's vital the National Cancer Plan for England transforms cancer care & boosts survival across all cancer types. bbc.co.uk/news/articles/c5ypโฆ
This is really big news for research against Alzheimer's disease!
Replenishing the brainโs natural stores of lithium can protect against and even reverse Alzheimerโs disease
go.nature.com/4mt8jSz
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Maybe I'm not a hypochondriac after all! My brain is just proactive against pathogens! ๐
Our brain-immune system axis has recently has some fascinating new findings
Here is one summarized
nature.com/articles/s41593-0โฆ
More here erictopol.substack.com/p/ourโฆ
