G3 Pharmaceuticals

Probably one of the most important days for galectin-3 since its discovery: Committment by a leading global corporation to develop galetin-3 inhibitors for prevention and therapy of human conditions. #galectin prn.to/34CMSq2

Probably the most important galectin-3 paper in years. We knew that an affected heart can induce kidney disease. This study reports the reverse – an affected kidney can induce a systemic and cardiac syndrome through the galectin-3 pathway. #galectin basictranslational.onlinejac…

Another elegant cardiac preclinical study showing the marked protective effect of pectin-derived galectin-3 inhibition.#galectin sciencedirect.com/science/ar…

In a large Chinese community population elevated levels of galectin-3 were associated with impairement in myocardial function. Perfectly fits the biology as we understand it and supports the urgency to investigate inhibitors. #galectin3 onlinelibrary.wiley.com/doi/…

Galectin-3 inhibitors can be extracted from common food crops. These inhibit HF development across animal models. Logic suggests that eating these plants may reduce incident HF. Another large study supports this. #galectin3 @MountSinaiNYC @kyla_lara sciencedirect.com/science/ar…

A new perspective: #galectin3 inhibition reduces cardiac damage in the acute phase in the injury-reperfusion (IR) model. disq.us/t/3g8i8zd

Another novel and authoritative contribution to our understanding of #galectin3 and CVD: Low Gal-3 was the strongest blood biomarker of low CHD and CVD risks. In animal models we can block Gal-3 and human testing may only be several years away. onlinejacc.org/content/74/1/…

Another elegant study supporting the role of galectin-3 as a mediator of the cardiorenal syndrome. Elevated galectin-3 predicts eGFR decline across baseline KDOQI classes. #galectin3 #heartfailure #CKD futuremedicine.com/doi/10.22…

MESA found a marked protective effect of DASH diet on the incidence of HF. Our theory: gut fermentation of fruits and vegetables release pectic fragments that, like MCP, inhibit galectin-3. Supports for the theory spans animal testing and epidemiology. doi.org/10.1016/j.amepre.201…

Study from @JACCJournals shows #Galectin3 is associated with adverse outcomes post MI. Elevated galectin-3 levels at time of MI strongly associated with mortality and HF independent of other key biomarkers like #Troponin and #sST2. #Gal3 #Heartfailure. bit.ly/2Q7vGTM.

Study from Journal of Clinical Medicine @JCM_MDPI shows that #Galectin3 levels within 24 hours post #myocardialinfarction was associated with all-cause mortality. bit.ly/2GYLsNJ.

Another species and another heart failure disease model support the importance of galectin-3 as an antifibrotic target in heart failure.. #galectin3 #heartfailure #fibrosis frontiersin.org/article/10.3…

Study from Journal of Cardiac Surgery shows elevated pre- and postoperative levels of #Galectin3 are associated with increased risk of 30-day readmission and mortality after paediatric congenital heart surgery. bit.ly/2I8N6Oy.

Another important study implicating galectin-3 in pathophysiology of #heartfailure. Study from @The_BMC in #JAHA_AHA reports #Galectin3 is independently associated with Stage B metabolic heart disease and #pulmonaryhypertension in young obese patients. bit.ly/2FZOwZv.

Novel Galectin-3 studies presented at #ACC19. Another piece that fits the puzzle of how galectin-3 mediates HF development. "Galectin 3: ‘Upstream’ Biomarker of Myocardial Dysfunction With Ageing". #galectin3 abstractsonline.com/pp8/#!/5…

Galectin Therapeutics (@GalectinGALT) says it will proceed with Phase 3 Development of GR-MD-02 for NASH Cirrhosis Following FDA Meeting #GALT #galectin #fibrosis bit.ly/2u91cH1.

Study from American Journal of Dermatopathology shows #Galectin1 and #Galectin3 may form supramolecular structure in #keloids which may influence #fibroblast morphology, adhesion, proliferation, migration, survival and inflammatory responses. #ECM bit.ly/2Xu7yhx.

#Galectin3 is a culprit of myocardial #fibrosis and inhibition of this protein effectively reduces organ fibrosis. #heartfailure @rudolf_deboer @escardio @ESC_Journals, bit.ly/2SHzR8v.

@BiomarkersMedicine @fsgbmm article shows #Galectin3 independently associated with arterial stiffness among #hemodialysis patients. #Galectin-3 #biomarker bit.ly/2IWUw9d.