@FurlanLab

We study chromatin conformation regulating transcriptional dynamics in mature cells

 IFC-UNAM, Mexico City
Joined January 2019
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A new manuscript from the lab!! Come have a read. A great effort from Karina Jácome and all authors. Congratulations!! We experimentally classified domain boundaries and discovered new proteins contributing to boundary function. track.smtpsendmail.com/90321…

Chromatin accessibility classification of TAD boundaries discloses new architectural proteins

Abstract. 3D genome organization is crucial to modulate gene expression. Topologically associating domain boundaries isolate genes and their regulatory ele

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Licona-Limón P-Lab@LabLiconaPAug 11
Today, I can finally share some incredibly exciting news. Our work, "TIF1γ regulates stability of regulatory T cells during inflammation," has been published in Nature Immunology. nature.com/articles/s41590-0…

TIF1γ regulates stability of regulatory T cells during inflammation

Nature Immunology - This study identifies TIF1γ as a critical regulator of regulatory T cell stability during inflammation. By restraining β-catenin–TCF7 signaling, TIF1γ...

nature.com
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Have a look at our recent publication!! Congratulations Abraham Roman-Figueroa @Ixorer and all co-authors. Nr5a2 is giving us a lot to study 🤗🤗 more coming soon!! link.springer.com/article/10…

NR5A2 controls gene expression and chromatin contacts of essential circadian metabolic genes in the...

Cellular and Molecular Life Sciences - Circadian regulation of gene expression relies on the coordinated action of core clock components, tissue-specific transcription factors, and epigenetic...

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Have a look at our journal club in Nature Reviews Cancer!!. Congrat @AuraGussinye9 and thank you @daniela_oaks for the invitation. nature.com/articles/s41568-0…
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Lacra Bintu@BintuLacra16 Dec 2025
We just finished writing up this beautiful story on how transcription factors can generate pulses by using chromatin (led by Cece & @ECosta173 ): Bifunctional transcriptional effector domains control gene expression pulses in an occupancy-dependent manner biorxiv.org/content/10.64898…

Bifunctional transcriptional effector domains control gene expression pulses in an occupancy-depe...

Dynamic gene expression pulses enable adaptive response to stimuli and can be generated in natural and synthetic systems. Controlling these dynamics typically involves circuits consisting of multiple...

biorxiv.org
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Fue un éxito!!! Muchas gracias a todos los ponentes y participantes que nos acompañaron. 🤗🤗🤗
Fisiología Celular UNAM@IFC_UNAM20 Nov 2025
Ayer en el instituto se llevó a cabo el Minisimposio por 25 años de Epigenética en México, un evento que reunió a ponentes nacionales e internacionales investigando diferentes rubros de la epigenética en distintos modelos. ¡Gracias por asistir!
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A great collaborative effort! Have a look 👇🏼👇🏼👇🏼 Genomic Kaleidoscope: On the Hidden Dimensions of Within-Species Genomic Diversity academic.oup.com/gbe/article…

The Genomic Kaleidoscope: On the Hidden Dimensions of Within-Species Genomic Diversity

Abstract. Genomic diversity within species encompasses a range of sequence-related, structural, and regulatory features. To illustrate their complexity, we

academic.oup.com
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No se lo pierdan!!! Minisimposio de epigenética en México. Un lineup increíble de ponentes!!! 18 y 19 de Noviembre en el IFC les esperamos (registro en el QR anexo).
Fisiología Celular UNAM@IFC_UNAM27 Oct 2025
🗓⏰📍Minisiposio por 25 años de Epigenética en México, martes 18 y miércoles 19 de noviembre de 9:30 a 17:00 hrs., auditorio Antonio Peña. Responde este formulario para acudir: forms.gle/VJnQRF9NKQxjLvye9 Algunas charlas se van a transmitir por YouTube: youtube.com/@institutodefisi…
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Liveposting on Bluesky: Lingbin Ni: Haplotype-resolved chromatin differences and genome structural variation #ASHG25 bsky.app/profile/michaelhoff…
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And it’s out! Thanks you @NatureSMB for the kind invitation! Come have a read 😊 “Returning home: a story of chromatin and community” rdcu.be/eJGcQ
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Replying to @arjunrajlab
There is a lot of truth to this. The advances in sequencing throughput continue. The one exception might be 3D genomics. 100x coverage of the human 3D genome at nucleosome resolution would require 10^16-17 reads: nature.com/articles/s41588-0…
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Licona-Limón P-Lab@LabLiconaP23 Sep 2025
Estimados colegas y miembros de la Sociedad Mexicana de Inmunología, les compartimos la propuesta de candidatura que el Dr José Luis Maravillas JL Maravillas Montero y yo estamos sometiendo para ocupar los puestos de vicepresidente y prosecretario de la SMI, voten por nosotros
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Shiori Iida@shiori_iida28 Aug 2025
Our new preprint is out! We combined single-nucleosome imaging and 3D-SIM to reveal: 🔹 Euchromatin forms condensed domains, not open fibers 🔹Cohesin loss increases nucleosome mobility without decompaction 🔹Cohesin prevents neighboring domain mixing Full story & movies👇
Kazuhiro Maeshima@kazu_maeshima28 Aug 2025
Is euchromatin really “open”? 🧬Our new study @bioRxiv suggests otherwise. Using super-resolution imaging🔬　@shiori_iida @MasaAShimazoe reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing. 🔗biorxiv.org/cgi/content/shor… (1/3)
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Satchin Panda
@SatchinPanda27 Aug 2025
Think babies are born without a body clock? ⏰ Not true! By the time they’re born, infants already have a working circadian system that responds to light. Here’s the timeline of how their internal clock develops before birth 👇@LauraKervezee frontiersin.org/journals/neu…
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Cell Reports@CellReports25 Aug 2025
Age-dependent effect of environmental enrichment on the neural 3D chromatin interactome dlvr.it/TMgcnJ

Age-dependent effect of environmental enrichment on the neural 3D chromatin interactome

Gancedo-Verdejo et al. reveal age-associated molecular changes in mouse hippocampus and an age-dependent effect of environmental enrichment, focusing on 3D chromatin structure and gene expression....

cell.com
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Eric Joyce@ericjoycelab14 Aug 2025
🚨New preprint from the lab🚨 🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK. biorxiv.org/content/10.1101/…

Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide...

The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their...

biorxiv.org
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Cees Dekker@cees_dekker13 Aug 2025
WORK! My lab currently have 5 (!) open positions for postdocs/PhD students for: -Nanopore protein sequencing -Archaeal CDV cell division -Microfluidics for synthetic cells -Nuclear Pore Complex -Origami mimics of peroxisomes Please apply! ceesdekkerlab.nl/come-join-u… RT=👍
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Valdes_Lab@Valdes_Lab_28 Jul 2025
SCIENCE IN MEXICO: A RISING FORCE AMID ADVERSITY. I came back knowing the funding would be scarce, the bureaucracy maddening, and the equipment overpriced. But also knowing I’d find freedom, brilliant students, and generous colleagues. I have no regrets shorturl.at/Mqd1N
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Very happy this is out. Come and have a read :)) It was a pleasure to write this with @Valdes_Lab_ Science in Mexico: a rising force amid adversity sciencedirect.com/science/ar…
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@IFC_UNAM
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