@FrukLab
Joined April 2018
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Online now! ✨Hartono et al develop a nanoprobe to enable urine-based detection of senescence burden, applicable to therapy-induced senescence in lung cancer and to lung fibrosis @danielMuozEspn1 @FrukLab @EarlyCancerCam @cebcambridge @Cambridge_Uni
Fruk Lab@FrukLabMay 13
Excited to share our latest work out today in @NatureAging from a collaboration between our lab @FrukLab and @MunozEspin_Lab! @EarlyCancerCam @cebcambridge 🔗nature.com/articles/s43587-0…
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Excited to share our latest work out today in @NatureAging from a collaboration between our lab @FrukLab and @MunozEspin_Lab! @EarlyCancerCam @cebcambridge 🔗nature.com/articles/s43587-0…
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This work was made possible thanks to the generous support of our funders: @CR_UK, @The_MRC, @EPSRC, @CambridgeBRC, @CRUKCamCentre, @CRUKCamThoracic, the WD Armstrong Studentship, the Darley/Sands Downing College Fellowship, and additional supporters.
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Read more: 📄Research paper: nature.com/articles/s43587-0… 📰 News & Views: nature.com/articles/s43587-0…

Urinary detection of therapy-induced senescence and fibrosis using an injectable albumin-based...

Nature Aging - Hartono and colleagues develop an injectable albumin-based nanoprobe to enable urine detection of senescence burden. By exploiting the activity of MMP-7 as a context-specific...

nature.com
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Thrilled to share the latest paper from a collaboration between our lab @MunozEspin_Lab @EarlyCancerCam and @FrukLab, and published today in @NatureAging
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Congratulations to Dr Matthew! 🎉 He successfully defended his PhD on hollow-core photonic crystal fibres for studying flavin-based photocatalysts. We’re so proud of his work and excited to see his impact as a postdoc at @EarlyCancerCam @Cambridge_Uni!
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The clay's the thing! 🪣 Research conducted at CEB has developed a brand new material from clay and vitamin B2 that could clean-up pollutants using nothing but sunlight. More: ceb.cam.ac.uk/news/flaponite 🧪⚙️🌱🔋 #ChemicalEngineering #Biotechnology #CambridgeUniversity @FrukLab
Scientist wearing purple gloves holds a glass flask in a laboratory, with scientific equipment visible in the background.

ALT Scientist wearing purple gloves holds a glass flask in a laboratory, with scientific equipment visible in the background.

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🌟Out now & on the cover of @CatalysisSciTec ! Meet Flaponite – our recyclable, flavin-based photocatalyst using LAPONITE clay as a green support. Enhanced activity, easy recovery, and inspired by nature! Congrats Matthew & the whole team!👏 🔗doi.org/10.1039/D5CY00146C
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We also offer a new perspective and suggest strategies for moving forward 🚀
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🎯 Antigen depletion by targeted nanoparticles; they can undermine their own targets
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💊 Dosing complexities that go well beyond what we see with small molecules
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In this article, we discuss three key challenges holding back the clinical translation of targeted nanomedicine: 👤 Pharmacokinetics of nanoparticle antibody conjugates; turns out they are not as straightforward as it seems
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If you're interested in targeted nanomedicine (and open to some opinions), check out our latest piece: "Reimagining drug nanocarriers: clinical realities and smarter strategies for targeted drug delivery" pubs.rsc.org/en/content/arti…

Reimagining drug nanocarriers: clinical realities and smarter strategies for targeted drug delivery

Recent advances in nanomedicine have significantly improved the delivery of small molecule therapies and biologics for cancer treatment, gene therapy, and

pubs.rsc.org
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We're delighted to announce the 2025 Danckwerts-Pergamon prize has been awarded to Muhammad Hartono for his innovative work on non-invasive lung cancer screening. Read more on our website: ceb.cam.ac.uk/news/danckwert… 🧪⚙️🌱🔋 #ChemicalEngineering #Biotechnology #Cambridge
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Check out a new review article published in collaboration with the Itzhaki lab! Read the full thread below 🧵👇
Fruk Lab@FrukLab14 May 2025
Excited to share our latest review in @angew_chem on nanoparticle-mediated targeted protein degradation (NanoPD)! Curious about nanotech and targeted protein degradation? Check it out! onlinelibrary.wiley.com/doi/… Thanks to @drew_baca @AdrianPTHo @LauraItzhaki @Lil2410

Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology

Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated...

onlinelibrary.wiley.com
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